Catalog No.
YHK68801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly15-Leu114
Predicted molecular weight
23.98 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9NRD5
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PRKCA-binding protein, Protein interacting with C kinase 1, PRKCABP, Protein kinase C-alpha-binding protein, PICK1
Clathrin-Independent Carriers/Glycosylphosphatidylinositol-Anchored-Protein-Enriched Endosomal Compartment Endocytic Pathway Is Critical for Enterovirus A71 Entry Into Human Oral Epidermoid Carcinoma KB Cells., PMID:40298088
PICK1 overexpression ameliorates endotoxin-induced acute lung injury by regulating mitochondrial quality control via maintaining Nrf-2 stabilization through activating the PI3K/Akt/GSK-3β pathway and disrupting the E3 ubiquitin ligase adapter β-TrCP., PMID:40286782
PICK1 links KIBRA and AMPA receptor subunit GluA2 in coiled-coil-driven supramolecular complexes., PMID:40074086
Protein interacting with C-kinase 1 (PICK1) regulates synaptic function and reversal learning in a mouse model for schizophrenia., PMID:39987275
Exploring vimentin's role in breast cancer via PICK1 alternative polyadenylation and the miR-615-3p-PICK1 interaction., PMID:39781570
Light-Modulated Circadian Synaptic Plasticity in the Somatosensory Cortex: Link to Locomotor Activity., PMID:39684579
Long-read and short-read RNA-seq reveal the transcriptional regulation characteristics of PICK1 in Baoshan pig testis., PMID:39371543
Peripherally restricted PICK1 inhibitor mPD5 ameliorates pain behaviors in murine inflammatory and neuropathic pain models., PMID:39287978
Utilizing AfDesign for Developing a Small Molecule Inhibitor of PICK 1-PDZ., PMID:39171592
Sodium arsenite induces aggresome formation by promoting PICK1 BAR domain homodimer formation., PMID:39083353
ICA1 affects APP processing through the PICK1-PKCα signaling pathway., PMID:38884369
Non-coding RNA yREX3 from human extracellular vesicles exerts macrophage-mediated cardioprotection via a novel gene-methylating mechanism., PMID:38865332
Unconventional PDZ Recognition Revealed in α7 nAChR-PICK1 Complexes., PMID:38691676
PICK1 inhibits the malignancy of nasopharyngeal carcinoma and serves as a novel prognostic marker., PMID:38664379
PICK1 links KIBRA and AMPA receptors in coiled-coil-driven supramolecular complexes., PMID:38558978
Targeting postsynaptic glutamate receptor scaffolding proteins PSD-95 and PICK1 for obesity treatment., PMID:38427737
Multi-omics study identifies that PICK1 deficiency causes male infertility by inhibiting vesicle trafficking in Sertoli cells., PMID:38001535
Phosphorylation of the AMPARs regulated by protein kinase C (PKC) and protein interacting with C-kinase 1 (PICK1) contribute to orofacial neuropathic pain., PMID:37709161
PDI augments kainic acid-induced seizure activity and neuronal death by inhibiting PP2A-GluA2-PICK1-mediated AMPA receptor internalization in the mouse hippocampus., PMID:37626185
Circulating ovarian hormones interact with protein interacting with C kinase (PICK1) within the medial prefrontal cortex to influence cocaine seeking in female mice., PMID:37541099
Knockdown of protein interacting with C α kinase 1 aggravates sepsis-induced acute liver injury by regulating the TLR4/NF-κB pathway., PMID:37488153
PICK1 modulates glycolysis and angiogenesis of hypoxic endothelial cells by regulating iron homeostasis., PMID:37368155
ICA69 regulates activity-dependent synaptic strengthening and learning and memory., PMID:37251649
Investigating the Mechanical Properties and Flexibility of N-BAR Domains in PICK1 by Molecular Dynamics Simulations., PMID:37218192
A vital role for PICK1 in the differential regulation of metabotropic glutamate receptor internalization and synaptic AMPA receptor endocytosis., PMID:37209824
PICK1-Deficient Mice Maintain Their Glucose Tolerance During Diet-Induced Obesity., PMID:37200849
Truncating PICK1 Variant Identified in Azoospermia Affected Mitochondrial Dysfunction in Knockout Mice., PMID:36971977
Hypoxia-induced degradation of PICK1 by RBCK1 promotes the proliferation of nasopharyngeal carcinoma cells., PMID:36934971
Novel Molecular Therapies and Genetic Landscape in Selected Rare Diseases with Hematologic Manifestations: A Review of the Literature., PMID:36766791
Exosomal miR-3131 derived from endothelial cells with KRAS mutation promotes EndMT by targeting PICK1 in brain arteriovenous malformations., PMID:36718590
The M1 muscarinic acetylcholine receptor regulates the surface expression of the AMPA receptor subunit GluA2 via PICK1., PMID:36564670
Structuring and validating a prognostic model for low-grade gliomas based on the genes for plasma membrane tension., PMID:36408514
Investigating the allosteric response of the PICK1 PDZ domain to different ligands with all-atom simulations., PMID:36251217
Modulation of Hippocampal Network Oscillation by PICK1-Dependent Cell Surface Expression of mGlu3 Receptors., PMID:36202617
Three Binding Conformations of BIO124 in the Pocket of the PICK1 PDZ Domain., PMID:35954295
A Role of the TEX101 Interactome in the Common Aetiology Behind Male Subfertility and Testicular Germ Cell Tumor., PMID:35774118
Ca 2+ Regulates Dimerization of the BAR Domain Protein PICK1 and Consequent Membrane Curvature., PMID:35721319
The Scaffold Protein PICK1 as a Target in Chronic Pain., PMID:35455935
Repression of autophagy leads to acrosome biogenesis disruption caused by a sub-chronic oral administration of polystyrene nanoparticles., PMID:35381522
The adaptor protein PICK1 targets the sorting receptor SorLA., PMID:35183222
Coding variants identified in patients with diabetes alter PICK1 BAR domain function in insulin granule biogenesis., PMID:35077398
A Novel Peripheral Action of PICK1 Inhibition in Inflammatory Pain., PMID:34975407
AMPA GluA2 subunit competitive inhibitors for PICK1 PDZ domain: Pharmacophore-based virtual screening, molecular docking, molecular dynamics simulation, and ADME studies., PMID:34809533
Electroacupuncture prevents LPS- induced neuroinflammation via upregulation of PICK-TLR4 complexes in the microglia of hippocampus., PMID:34673136
FSC231 alleviates paclitaxel-induced neuralgia by inhibiting the interactions between PICK1 and GluA2 and activates GSK-3β and ERK1/2., PMID:34582111
The PICK1/TLR4 complex on microglia is involved in the regulation of LPS-induced sepsis-associated encephalopathy., PMID:34500285
PICK1 Deficiency Exacerbates Sepsis-Associated Acute Kidney Injury., PMID:34307672
Amyloid-β (1-42) peptide induces rapid NMDA receptor-dependent alterations at glutamatergic synapses in the entorhinal cortex., PMID:34144329
Sex-specific role for prefrontal cortical protein interacting with C kinase 1 in cue-induced cocaine seeking., PMID:34110073
The Arp2/3 Inhibitory Protein Arpin Is Required for Intestinal Epithelial Barrier Integrity., PMID:34012961
For research use only. Not for human or drug use.
