Catalog No.
YHK68701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala666-Cys838
Predicted molecular weight
21.29 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8WYR1
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PIK3R5, Phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit, PI3-kinase regulatory subunit 5, PtdIns-3-kinase regulatory subunit, Phosphoinositide 3-kinase regulatory subunit 5, PtdIns-3-kinase p101, p101-PI3K, Protein FOAP-2, PI3-kinase p101 subunit
Targeting a lineage-specific PI3Kɣ-Akt signaling module in acute myeloid leukemia using a heterobifunctional degrader molecule., PMID:38816660
Targetable leukaemia dependency on noncanonical PI3Kγ signalling., PMID:38720074
Targetable leukemia dependency on noncanonical PI3Kγ signaling., PMID:38328043
Identification of PIK3R5 as a hub in septic myocardial injury and the cardioprotective effects of Psoralidin., PMID:37918280
Bioinformatics and Systems Biology Approach to Identify the Pathogenetic Link between Heart Failure and Sarcopenia., PMID:37909603
[Establishment of a prostate cancer prognostic risk model based on the TCGA database and inflammation-related genes]., PMID:37846114
lncRNA Helf promotes hepatic inflammation and fibrosis by interacting with PTBP1 to facilitate PIK3R5 mRNA stabilization., PMID:37805473
Effects of external environment on promoter methylation of PIK3R5 and related pathway regulation in steroid-induced femoral head necrosis., PMID:37709244
Angioimmunoblastic T-cell lymphoma: Novel recurrent mutations and prognostic biomarkers by cell-free DNA profiling., PMID:37646306
Amelioration effects of α-viniferin on hyperuricemia and hyperuricemia-induced kidney injury in mice., PMID:37209608
Molecular basis for differential activation of p101 and p84 complexes of PI3Kγ by Ras and GPCRs., PMID:36842083
Nonsense-mediated mRNA decay promote C2C12 cell proliferation by targeting PIK3R5., PMID:36512272
Silencing of IRF8 Mediated by m6A Modification Promotes the Progression of T-Cell Acute Lymphoblastic Leukemia., PMID:36478193
Integrated genomic, transcriptomic, and epigenetic analyses identify a leukotriene synthesis-related M2 macrophage gene signature that predicts prognosis and treatment vulnerability in gliomas., PMID:36159811
Exosomes from dysfunctional chondrocytes affect osteoarthritis in Sprague-Dawley rats through FTO-dependent regulation of PIK3R5 mRNA stability., PMID:36066338
Role of Phosphatidylinositol 3-Kinase and Its Catalytic Unit PIK3CA in Cervical Cancer: A Mini-Review., PMID:36046780
Clinical and Genetic Characterization of Brazilian Patients with Ataxia and Oculomotor Apraxia., PMID:35426160
Identification of miRNAs and their potential effects on multiple sclerosis related pathways using ın silico analysis., PMID:35121245
Identification of Gene Co-Expression Networks Associated with Consensus Molecular Subtype-1 of Colorectal Cancer., PMID:34830978
PIK3R5 genetic predictors of hypertension induced by VEGF-pathway inhibitors., PMID:34775477
Integrated multiplex network based approach for hub gene identification in oral cancer., PMID:34258466
HCP5, as the sponge of miR-1291, facilitates AML cell proliferation and restrains apoptosis via increasing PIK3R5 expression., PMID:34187569
In-Silico Study of Immune System Associated Genes in Case of Type-2 Diabetes With Insulin Action and Resistance, and/or Obesity., PMID:33927693
Diverse mechanisms activate the PI 3-kinase/mTOR pathway in melanomas: implications for the use of PI 3-kinase inhibitors to overcome resistance to inhibitors of BRAF and MEK., PMID:33549048
The pharmacodynamic and differential gene expression analysis of PPAR α/δ agonist GFT505 in CDAHFD-induced NASH model., PMID:33326461
Phosphoinositide 3'-Kinase γ Facilitates Polyomavirus Infection., PMID:33092168
Transcriptomic analysis reveals the role of a peptide derived from CRYAB on the CoCl2-induced hypoxic HL-1 cardiomyocytes., PMID:32621152
High-Throughput Sequencing and Exploration of the lncRNA-circRNA-miRNA-mRNA Network in Type 2 Diabetes Mellitus., PMID:32596376
Signaling Inhibitors Accelerate the Conversion of mouse iPS Cells into Cancer Stem Cells in the Tumor Microenvironment., PMID:32572057
miR-210-5p promotes epithelial-mesenchymal transition by inhibiting PIK3R5 thereby activating oncogenic autophagy in osteosarcoma cells., PMID:32024814
Dietary hemin promotes colonic preneoplastic lesions and DNA damage but not tumor development in a medium-term model of colon carcinogenesis in rats., PMID:31585636
Transcriptome analysis revealed ameliorative effect of probiotic Lactobacillus johnsonii BS15 against subclinical necrotic enteritis induced hepatic inflammation in broilers., PMID:31077753
Genetic Profiles Associated with Chemoresistance in Patient-Derived Xenograft Models of Ovarian Cancer., PMID:30428638
Discovery and Validation of Methylation Biomarkers for Ulcerative Colitis Associated Neoplasia., PMID:29762666
Catechin supplemented in a FOS diet induces weight loss by altering cecal microbiota and gene expression of colonic epithelial cells., PMID:29748675
A Comprehensive Survey of the Roles of Highly Disordered Proteins in Type 2 Diabetes., PMID:28934129
Screening for the protective effect target of deproteinized extract of calf blood and its mechanisms in mice with CCl4-induced acute liver injury., PMID:28700704
Identification of the acclimation genes in transcriptomic responses to heat stress of White Pekin duck., PMID:28634817
A food-based approach that targets interleukin-6, a key regulator of chronic intestinal inflammation and colon carcinogenesis., PMID:28193578
Analysis of molecular markers as predictive factors of lymph node involvement in breast carcinoma., PMID:28123587
RNA transcript expression of IGF-I/PI3K pathway components in regenerating skeletal muscle is sensitive to initial injury intensity., PMID:27647425
[A preliminary analysis on potentially targeted genes of induced chemotherapy in supraglottic laryngeal squamous cell carcinoma]., PMID:27480298
Screening of potential biomarkers for chemoresistant ovarian carcinoma with miRNA expression profiling data by bioinformatics approach., PMID:26622864
An Integrative Approach for Mapping Differentially Expressed Genes and Network Components Using Novel Parameters to Elucidate Key Regulatory Genes in Colorectal Cancer., PMID:26222778
Identification of genes and long non-coding RNAs associated with the pathogenesis of gastric cancer., PMID:26177842
Association between germline single nucleotide polymorphisms in the PI3K-AKT-mTOR pathway, obesity, and breast cancer disease-free survival., PMID:25108739
miRNA-155 controls mast cell activation by regulating the PI3Kγ pathway and anaphylaxis in a mouse model., PMID:24734904
Molecular determinants of PI3Kγ-mediated activation downstream of G-protein-coupled receptors (GPCRs)., PMID:24190998
Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response., PMID:23006971
Novel somatic mutations to PI3K pathway genes in metastatic melanoma., PMID:22912864
For research use only. Not for human or drug use.
