Catalog No.
YHK68601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
His61-Glu364
Predicted molecular weight
37.40 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9HBI1
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Beta-parvin, Affixin, PARVB
A comprehensive evaluation of candidate genetic polymorphisms in a large histologically characterized MASLD cohort using a novel framework., PMID:40434633
Identification of Biomarkers for Meat Quality in Sichuan Goats Through 4D Label-Free Quantitative Proteomics., PMID:40150416
Identifying Hub Genes and Metabolic Pathways in Collagen VI-Related Dystrophies: A Roadmap to Therapeutic Intervention., PMID:39595553
PARVB deficiency alleviates cisplatin-induced tubular injury by inhibiting TAK1 signaling., PMID:39235496
Targeting the High-Density Lipoprotein Proteome for the Treatment of Post-Acute Sequelae of SARS-CoV-2., PMID:38674105
Exploring the molecular and immune-landscape of lung cancer associated with cystic airspaces., PMID:38430689
PARVB and HSD17B13 variants are associated with nonalcoholic fatty liver disease in children., PMID:38418429
Inhibition of the ILK-AKT pathway by upregulation of PARVB contributes to the cochlear cell death in Fascin2 gene knockout mice., PMID:38374196
PARVB promotes malignant melanoma progression and is enhanced by hypoxic conditions., PMID:38301409
TET2-mediated ECM1 hypomethylation promotes the neovascularization in active proliferative diabetic retinopathy., PMID:38172938
Evaluation of novel biomarkers for early pregnancy outcome prediction†., PMID:38011676
A novel NET-related gene signature for predicting DLBCL prognosis., PMID:37716978
Differentially Expressed Genes Induced by Erythropoietin Receptor Overexpression in Rat Mammary Adenocarcinoma RAMA 37-28 Cells., PMID:37239828
Candidate Genes and Gene Networks Change with Age in Japanese Black Cattle by Blood Transcriptome Analysis., PMID:36833431
PARP3 supervises G9a-mediated repression of adhesion and hypoxia-responsive genes in glioblastoma cells., PMID:36109561
Focal adhesion proteins in hepatocellular carcinoma: RSU1 a novel tumour suppressor with prognostic significance., PMID:35642986
Comprehensive genomic profiling of EWSR1/FUS::CREB translocation-associated tumors uncovers prognostically significant recurrent genetic alterations and methylation-transcriptional correlates., PMID:35347249
α-Parvin Defines a Specific Integrin Adhesome to Maintain the Glomerular Filtration Barrier., PMID:35260418
C/D box snoRNA SNORD113-6/AF357425 plays a dual role in integrin signalling and arterial fibroblast function via pre-mRNA processing and 2'O-ribose methylation., PMID:34673944
Blood and affective markers of stress in Elite Airmen during a preparatory training course: A pilot study., PMID:33912629
Integrin-linked kinase (ILK) regulates KRAS, IPP complex and Ras suppressor-1 (RSU1) promoting lung adenocarcinoma progression and poor survival., PMID:32592097
DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25., PMID:32528174
RNA sequencing-based transcriptome profiling of cardiac tissue implicates novel putative disease mechanisms in FLNC-associated arrhythmogenic cardiomyopathy., PMID:31843279
Phenotypic relationships, genetic parameters, genome-wide associations, and identification of potential candidate genes for ketosis and fat-to-protein ratio in German Holstein cows., PMID:31056336
The cardiac syndecan-4 interactome reveals a role for syndecan-4 in nuclear translocation of muscle LIM protein (MLP)., PMID:30967474
Genetics of nonalcoholic fatty liver disease in Asian populations., PMID:30945694
Evidence for skeletal muscle fiber type-specific expressions of mechanosensors., PMID:30701284
Parvins Are Required for Endothelial Cell-Cell Junctions and Cell Polarity During Embryonic Blood Vessel Formation., PMID:29567677
Decrypting the PAK4 transcriptome profile in mammary tumor forming cells using Next Generation Sequencing., PMID:29055713
24-Methylenecycloartanyl ferulate, a major compound of γ-oryzanol, promotes parvin-beta expression through an interaction with peroxisome proliferator-activated receptor-gamma 2 in human breast cancer cells., PMID:26549231
Association of rs5764455 and rs6006473 polymorphisms in PARVB with liver damage of nonalcoholic fatty liver disease in Han Chinese population., PMID:26343796
The Riddle of Nonalcoholic Fatty Liver Disease: Progression From Nonalcoholic Fatty Liver to Nonalcoholic Steatohepatitis., PMID:26155043
Focal Adhesion Proteins α- and β-Parvin are Overexpressed in Human Colorectal Cancer and Correlate with Tumor Progression., PMID:26115385
Targeted-bisulfite sequence analysis of the methylation of CpG islands in genes encoding PNPLA3, SAMM50, and PARVB of patients with non-alcoholic fatty liver disease., PMID:25776890
PARVB overexpression increases cell migration capability and defines high risk for endophytic growth and metastasis in tongue squamous cell carcinoma., PMID:25422907
Pooled genetic analysis in ultrasound measured non-alcoholic fatty liver disease in Indian subjects: A pilot study., PMID:25018854
Interstitial 22q13 deletions not involving SHANK3 gene: a new contiguous gene syndrome., PMID:24700646
Targeted next-generation sequencing and fine linkage disequilibrium mapping reveals association of PNPLA3 and PARVB with the severity of nonalcoholic fatty liver disease., PMID:24621583
An integrin-linked machinery of cytoskeletal regulation that enables experimental tumor initiation and metastatic colonization., PMID:24035453
Pathway analysis using genome-wide association study data for coronary restenosis--a potential role for the PARVB gene., PMID:23950981
Global protein quantification of mouse heart tissue based on the SILAC mouse., PMID:23606247
Genome-wide scan revealed that polymorphisms in the PNPLA3, SAMM50, and PARVB genes are associated with development and progression of nonalcoholic fatty liver disease in Japan., PMID:23535911
Migfilin, α-parvin and β-parvin are differentially expressed in ovarian serous carcinoma effusions, primary tumors and solid metastases., PMID:23099104
Structural basis for paxillin binding and focal adhesion targeting of β-parvin., PMID:22869380
Activation of Bmp2-Smad1 signal and its regulation by coordinated alteration of H3K27 trimethylation in Ras-induced senescence., PMID:22072987
Caveolin-1 and integrin β1 regulate embryonic stem cell proliferation via p38 MAPK and FAK in high glucose., PMID:21506116
NCI60 cancer cell line panel data and RNAi analysis help identify EAF2 as a modulator of simvastatin and lovastatin response in HCT-116 cells., PMID:21483694
Affixin (β-parvin) promotes cardioprotective signaling via STAT3 activation., PMID:21295579
Expression of parvin-beta is a prognostic factor for patients with urothelial cell carcinoma of the upper urinary tract., PMID:20736946
The Legionella pneumophila F-box protein Lpp2082 (AnkB) modulates ubiquitination of the host protein parvin B and promotes intracellular replication., PMID:20345489
For research use only. Not for human or drug use.
