Catalog No.
YHB05001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Asp121
Predicted molecular weight
15.42 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O60934
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Nibrin, P95, NBS1, Cell cycle regulatory protein p95, NBS, Nijmegen breakage syndrome protein 1, NBN
Cerebrospinal fluid and brain positron emission tomography measures of synaptic vesicle glycoprotein 2A: Biomarkers of synaptic density in Alzheimer's disease., PMID:40491249
Genome rearrangements induced by the stimulation of end-joining of DNA double strand breaks through multiple phosphorylation of MRE11 by the kinase PKB/AKT1., PMID:40479710
PRDX1 protects ATM from arsenite-induced proteotoxicity and maintains its stability during DNA damage signaling., PMID:40387816
Inherited deficiency of DIAPH1 identifies a DNA double strand break repair pathway regulated by γ-actin., PMID:40368919
Assessment of the relationship between synaptic density and metabotropic glutamate receptors in early Alzheimer's disease: a multi-tracer PET study., PMID:40329311
Identification of non-synonymous SNPs affecting structure and function of MLH1 and NBN proteins: a computational approach., PMID:40312597
Identification of hub genes related to DNA damage response in asthma via combinative bioinformatics strategy., PMID:40288048
Role of MRE11 in DNA damage repair pathway dynamics and its diagnostic and prognostic significance in hereditary breast and ovarian cancer., PMID:40205351
Aβ impairs the LTP-related movement of endogenous CaMKII but not of exogenous GFP-CaMKII., PMID:40137857
EWSR1::CREM Fusion in a Pediatric Patient With Testicular Leydig Cell Tumor., PMID:40072299
NBS1 facilitates preribosomal RNA biogenesis., PMID:40067889
Fibroblast-based radiosensitivity assays as a clinically valuable tool for (severe) combined immunodeficiency syndromes., PMID:40044379
Phosphorylated BLM peptide acts as an agonist for DNA damage response., PMID:39997217
Germline Pathogenic Variants and Clinical Outcomes in Asian Patients With Breast Cancer., PMID:39930910
Interconnections between BDH1-plasma protein-type 2 diabetes Mellitus: a mediated mendelian randomization analysis using plasma proteomics., PMID:39870808
An exceptionally rare case of a diffuse midline glioma with concomitant H3.1 K27M and G34R mutations in the HIST1H3C (H3C3) gene., PMID:39815339
Repeated ionizing radiation exposure induces TRIP13 expression, conferring radioresistance in lung cancer cells., PMID:39762328
Hepatitis B virus hijacks MRE11-RAD50-NBS1 complex to form its minichromosome., PMID:39752632
Neuroblastoma Occurring in Nijmegen Breakage Syndrome., PMID:39737638
Interaction of DDB1 with NBS1 in a DNA Damage Checkpoint Pathway., PMID:39684807
Bioactivated Glucoraphanin Improves Cell Survival, Upregulating Phospho-AKT, and Modulates Genes Involved in DNA Repair in an In Vitro Alzheimer's Disease Model: A Network-Transcriptomic Analysis., PMID:39683594
Phosphorylation of 'SDT-like' motifs in ATRX mediates its interaction with the MRN complex and is important for ALT pathway suppression., PMID:39657822
The ataxia-telangiectasia disease protein ATM controls vesicular protein secretion via CHGA and microtubule dynamics via CRMP5., PMID:39615799
The interplay of DNA repair context with target sequence predictably biases Cas9-generated mutations., PMID:39592573
Multi-ethnic heterozygote frequencies of cancer susceptibility genes to inform counseling of reproductive risk., PMID:39570271
Multi-target therapeutic modulation with natural compounds towards DNA repair MRN-checkpoint sensor genes (MRN-CSGs) and oncogenic miRNAs in breast cancer patients: a Clinico-Informatic study., PMID:39568384
Machine learning-based gene expression biomarkers to distinguish Zika and Dengue virus infections: implications for diagnosis., PMID:39464736
Plasma Proteomics of Type 2 Diabetes, Hypertension, and Co-Existing Diabetes/Hypertension in Thai Adults., PMID:39459569
NBS1 dePARylation by NUDT16 is critical for DNA double-strand break repair., PMID:39438373
Mechanism of BRCA1-BARD1 function in DNA end resection and DNA protection., PMID:39261728
NBS1 lactylation and damaged DNA repair., PMID:39179095
Unraveling druggable cancer-driving proteins and targeted drugs using artificial intelligence and multi-omics analyses., PMID:39169044
The small molecule inhibitor of SARS-CoV-2 3CLpro EDP-235 prevents viral replication and transmission in vivo., PMID:39090095
Establishment and characterization of a novel MDM2/MYCN-co-amplified neuroblastoma cell line, NBN-SHIM, established from a late recurrent stage MS tumor., PMID:39080217
Expression of DDSR1 Long Non-Coding RNA and Genes Involved in the DNA Damage Response in Sperm with DNA Fragmentation., PMID:39014289
Predictive modeling of gene mutations for the survival outcomes of epithelial ovarian cancer patients., PMID:38976671
NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance., PMID:38961290
[Mechanisms of the Effect of Maternal Age-Related Oocyte Aging on Fertility: Transcriptomic Sequencing Analysis of a Zebrafish Model]., PMID:38948296
A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex., PMID:38943005
Germline pathogenic variants in the MRE11, RAD50, and NBN (MRN) genes in cancer predisposition: A systematic review and meta-analysis., PMID:38924040
A Systematic Review of the Prevalence of Germline BRCA mutations in North Asia Breast Cancer Patients., PMID:38918649
Targeted serum proteome profiling reveals nicotinamide adenine dinucleotide phosphate (NADPH)-related biomarkers to discriminate linear IgA bullous disorder from dermatitis herpetiformis., PMID:38908771
Identification of RAD17 as a candidate cancer predisposition gene in families with histories of pancreatic and breast cancers., PMID:38872153
PTEN inhibition enhances sensitivity of ovarian cancer cells to the poly (ADP-ribose) polymerase inhibitor by suppressing the MRE11-RAD50-NBN complex., PMID:38866962
NBN: protein instability, ALL susceptibility., PMID:38814657
Clinical relevance of double heterozygosity revealed by next-generation sequencing of homologous recombination repair pathway genes in South African breast cancer patients., PMID:38814507
Radiosensitivity in a newborn with microcephalia: A case report of Nijmegen breakage syndrome., PMID:38761025
Somatic structural variants drive distinct modes of oncogenesis in melanoma., PMID:38758740
BER genes expression in oral and pre-oral cancer: Combinatorial approach to propose potential biomarker., PMID:38718710
Clinical actionability of BRCA2 alterations in uterine leiomyosarcoma: a molecular tumor board case report and a cBioPortal comprehensive analysis., PMID:38716772
For research use only. Not for human or drug use.
