Catalog No.
YHA16101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu161-Ser410
Predicted molecular weight
30.58 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O00571
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
DEAD box, X isoform, CAP-Rf, DDX3, HLP2, DEAD box protein 3, X-chromosomal, DDX3X, ATP-dependent RNA helicase DDX3X, Helicase-like protein 2, DBX
Liquid-liquid phase separation of DDX3X: mechanisms, pathological implications, and therapeutic potential., PMID:40456342
Involvement of lncRNAs NEAT1 and ZBTB11-AS1 in Active and Persistent HIV-1 Infection in C20 Human Microglial Cell Line., PMID:40429887
Pathogenic mutations disrupt stress granules assembly in patients with DDX3X neurodevelopmental disorder., PMID:40418049
Ophiopogonin C protects against acute lung injury by fatal sepsis through pyroptosis macrophage., PMID:40397999
Proliferating Microglia Exhibit Unique Transcriptional and Functional Alterations in Alzheimer's Disease., PMID:40387894
An in-cell helicase reporter system for quantifying DDX3X and DDX3Y activities., PMID:40385543
Evaluating the clinical utility and strategy of whole-exome sequencing testing for fetuses with increased nuchal translucency., PMID:40381797
Sex-specific perturbations of neuronal development caused by mutations in the autism risk gene DDX3X., PMID:40374608
The host cell factor DDX3 mediates sex dimorphism in the IFNα response of plasmacytoid dendritic cells upon TLR activation., PMID:40354846
LINC00908 Inactivates Wnt/β-Catenin Signaling Pathway to Inhibit Prostate Cancer Cell Stemness via Upregulating GSK3B and FBXW2., PMID:40344383
Minding the synapse: A multi-omic approach reveals hidden regulators of neurodevelopment., PMID:40245839
Japanese encephalitis virus NS1 inhibits IFN-β production by interacting with DDX3X., PMID:40231822
KPNA2 promotes osteosarcoma progression by regulating the alternative splicing of DDX3X mediated by YBX1., PMID:40216969
irCLIP-RNP and Re-CLIP reveal patterns of dynamic protein assemblies on RNA., PMID:40140581
YAP-mediated DDX3X confers resistance to ferroptosis in breast cancer cells by reducing lipid peroxidation., PMID:40089076
Discovery of RNA-Protein Molecular Clamps Using Proteome-Wide Stability Assays., PMID:40077831
Integrated multi-omic characterizations of the synapse reveal RNA processing factors and ubiquitin ligases associated with neurodevelopmental disorders., PMID:40054464
RNA Helicase DDX3 Interacts with the Capsid Protein of Hepatitis E Virus and Plays a Vital Role in the Viral Replication., PMID:40005552
Diverse mechanisms of DDX3Y suppression by DDX3X., PMID:39975375
Characterization of the genomic landscape of canine diffuse large B-cell lymphoma reveals recurrent H3K27M mutations linked to progression-free survival., PMID:39922874
A subpopulation of cortical neurons altered by mutations in the autism risk gene DDX3X., PMID:39878593
Identification and Functional Analysis of PANoptosis-Associated Genes in the Progression From Sepsis to ARDS., PMID:39854144
Multi-modal investigation reveals pathogenic features of diverse DDX3X missense mutations., PMID:39836689
Modulation of DAPK1 expression by its alternative splice variant DAPK1-215 in cancer., PMID:39833825
Diagnostic Power of MicroRNAs in Melanoma: Integrating Machine Learning for Enhanced Accuracy and Pathway Analysis., PMID:39823244
Post-transcriptional cross- and auto-regulation buffer expression of the human RNA helicases DDX3X and DDX3Y., PMID:39794123
4D-DIA-Based Quantitative Proteomic Analysis Reveals the Involvement of TRPV2 Protein in Duck Tembusu Virus Replication., PMID:39772141
G3BP-driven RNP granules promote inhibitory RNA-RNA interactions resolved by DDX3X to regulate mRNA translatability., PMID:39729994
miR-135a-5p alleviates cerebral ischemia-reperfusion injury by inhibiting pyroptosis mediated through the DDX3X/NLRP3 pathway., PMID:39719209
Melatonin mitigates intervertebral disc degeneration by suppressing NLRP3 inflammasome activation via the EGR1/DDX3X pathway., PMID:39708233
Depressed TFAM promotes acetaminophen-induced hepatotoxicity regulated by DDX3X-PGC1α-NRF2 signaling pathway., PMID:39701936
Sex-specific perturbations of neuronal development caused by mutations in the autism risk gene DDX3X., PMID:39605424
DDX3X Activates Chondrocyte Pyroptosis to Promote Osteoarthritis Progression., PMID:39592517
RNA helicases DDX3X and DDX3Y form nanometer-scale RNA-protein clusters that support catalytic activity., PMID:39591970
MANF inhibits NLRP3 inflammasome activation by competitively binding to DDX3X in paraquat-stimulated alveolar macrophages., PMID:39547060
DDX3 participates in miRNA biogenesis and RNA interference through translational control of PACT and interaction with AGO2., PMID:39543456
Targeting DDX3X eliminates leukemia stem cells in chronic myeloid leukemia by blocking NT5DC2 mRNA translation., PMID:39516658
Specific catalytically impaired DDX3X mutants form sexually dimorphic hollow condensates., PMID:39500865
Deficiency of DDX3X results in neurogenesis defects and abnormal behaviors via dysfunction of the Notch signaling., PMID:39471229
Recognisable Neuroradiological Findings in Five Neurogenetic Disorders., PMID:39462795
irCLIP-RNP and Re-CLIP reveal patterns of dynamic protein associations on RNA., PMID:39386644
DDX3X dynamics, glioblastoma's genetic landscape, therapeutic advances, and autophagic interplay., PMID:39368002
CircTMTC1 Mediates Nucleocytoplasmic Translocation of DDX3X to Regulate Osteogenic Differentiation of Human Ligamentum Flavum Cells., PMID:39351864
The cytoplasmic-nuclear transport of DDX3X promotes immune-mediated liver injury in mice regulated by endoplasmic reticulum stress., PMID:39349420
Targeting RNA helicase DDX3X with a small molecule inhibitor for breast cancer bone metastasis treatment., PMID:39306228
Chemoproteomic profiling unveils binding and functional diversity of endogenous proteins that interact with endogenous triplex DNA., PMID:39223307
DMDA-PatA mediates RNA sequence-selective translation repression by anchoring eIF4A and DDX3 to GNG motifs., PMID:39223140
Cell-free analysis reveals the role of RG/RGG motifs in DDX3X phase separation and their potential link to cancer pathogenesis., PMID:39222785
Synergistic action of human RNaseH2 and the RNA helicase-nuclease DDX3X in processing R-loops., PMID:39189461
PRRSV hijacks DDX3X protein and induces ferroptosis to facilitate viral replication., PMID:39155369
For research use only. Not for human or drug use.
