Catalog No.
YHK66401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asn229-Ser589
Predicted molecular weight
42.79 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q99661
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Mitotic centromere-associated kinesin, Kinesin-like protein 6, KIF2C, Kinesin-like protein KIF2C, KNSL6, MCAK
Mixture of common and uncommon pathways and genes regulating primary and secondary immunoglobulin M responses in chickens., PMID:40499239
KIF2C condensation concentrates PLK1 and phosphorylated BRCA2 on kinetochore microtubules in mitosis., PMID:40498077
Tumor suppressor FBXO11 drives ubiquitin proteasomal degradation of KIF2C to limit ovarian cancer progression and is transcriptionally repressed by ZNF217., PMID:40447129
Prepubertal exposure to 17β-estradiol downregulates motor protein genes, impairs sperm flagella formation, and reduces fertility in Nile tilapia (Oreochromis niloticus)., PMID:40412113
A comprehensive review and in silico analysis of the role of survivin (BIRC5) in hepatocellular carcinoma hallmarks: A step toward precision., PMID:40306500
KIF2C promotes oral squamous cell carcinoma progression via PLK1 upregulation: implications for biomarker development and therapeutic targeting., PMID:40293559
Elevated KIF2C Expression Drives Osteosarcoma Progression by Modulating the Wnt/β-Catenin Signaling Pathway and Contributing to an Immunosuppressive Tumor Microenvironment., PMID:40292920
KIF2C is essential for meiosis and manchette dynamics in male mice., PMID:40213390
MCAK/Kif2C centromeric activity level tunes K-fiber stability., PMID:40027728
CENPF as a prognostic marker of glioma: unraveling the molecular mechanisms., PMID:40019588
Comparative RNA-Seq analysis of differentially expressed genes in the sertoli cells of yak and cattle-yak., PMID:39987073
BRD4 interacting genes as prognostic biomarkers in hepatocellular carcinoma for optimized treatment strategies., PMID:39955326
Integrative Bioinformatics Analysis for Targeting Hub Genes in Hepatocellular Carcinoma Treatment., PMID:39911278
CENP-E haploinsufficiency causes chromosome misalignment and spindle assembly checkpoint activation in the spermatogonia., PMID:39737806
CCDC69 maintains genome integrity by regulating KIF2C/MCAK depolymerase activity and the stability of the chromosomal passenger complex., PMID:39638803
Recent advancements in mechanistic research, therapeutic potential, and structure-activity relationships of aurora kinase inhibitors in cancer therapies., PMID:39603069
Identification and Validation of Telomere-Related Gene Signature in Intervertebral Disc Degeneration., PMID:39553152
Genome-wide binding analysis unveils critical implication of B-Myb-mediated transactivation in cancers., PMID:39309447
Transcriptomic landscape of quiescent and proliferating human corneal stromal fibroblasts., PMID:39243928
Molecular Alterations Associated with Histologically Overt Stromal Response in Patients with Prostate Cancer., PMID:39201599
Identification of novel biomarkers and potential molecular targets for uterine cancer using network-based approach., PMID:39029376
KIF2C as a potential therapeutic target: insights from lung adenocarcinoma subtype classification and functional experiments., PMID:38940931
KIF2C is a critical regulator for malignant progression of head and neck squamous cell carcinoma., PMID:38859848
MEF2C contributes to axonal branching by regulating Kif2c transcription., PMID:38663879
Constructing lactylation-related genes prognostic model to effectively predict the disease-free survival and treatment responsiveness in prostate cancer based on machine learning., PMID:38566813
Bioinformatics-based screening and analysis of the key genes involved in the influence of antiangiogenesis on myeloid-derived suppressor cells and their effects on the immune microenvironment., PMID:38526604
Nek2A prevents centrosome clustering and induces cell death in cancer cells via KIF2C interaction., PMID:38493150
KIF2C/MCAK a prognostic biomarker and its oncogenic potential in malignant progression, and prognosis of cancer patients: a systematic review and meta-analysis as biomarker., PMID:38344808
KIF2C: An important factor involved in signaling pathways, immune infiltration, and DNA damage repair in tumorigenesis., PMID:38237349
Silencing of KIF2C enhances the sensitivity of hepatocellular carcinoma cells to cisplatin through regulating the PI3K/AKT/MAPK signaling pathway., PMID:38170762
Production of CRISPR-Cas9 Transgenic Cell Lines for Knocksideways Studies., PMID:38153181
Identification of druggable hub genes and key pathways associated with cervical cancer by protein-protein interaction analysis: An in silico study., PMID:38077941
Cascading effects of hypobaric hypoxia on the testis: insights from a single-cell RNA sequencing analysis., PMID:38033870
Potential 'anti-cancer' effects of esketamine on proliferation, apoptosis, migration and invasion in esophageal squamous carcinoma cells., PMID:37968758
Structure-based virtual screening and molecular docking approaches to identify potential inhibitors against KIF2C to combat glioma., PMID:37942622
KIF2C promotes clear cell renal cell carcinoma progression via activating JAK2/STAT3 signaling pathway., PMID:37863123
Transcriptome analysis of meiotic and post-meiotic spermatogenic cells reveals the potential hub genes of aging on the decline of male fertility., PMID:37839768
A Network of 17 Microtubule-Related Genes Highlights Functional Deregulations in Breast Cancer., PMID:37835564
Origin recognition complex subunit 1(ORC1) is a potential biomarker and therapeutic target in cancer., PMID:37833711
Bioinformatical analysis of the key differentially expressed genes for screening potential biomarkers in Wilms tumor., PMID:37717078
The kinesin-14 family motor protein KIFC2 promotes prostate cancer progression by regulating p65., PMID:37716704
Lumican silencing ameliorates β-glycerophosphate-mediated vascular smooth muscle cell calcification by attenuating the inhibition of APOB on KIF2C activity., PMID:37711155
Bioinformatics Analysis and Screening of Potential Target Genes Related to the Lung Cancer Prognosis., PMID:37708874
Lysosome-related genes: A new prognostic marker for lung adenocarcinoma., PMID:37657029
An Aurora kinase A-BOD1L1-PP2A B56 Axis promotes chromosome segregation fidelity., PMID:37609141
CEACAM1 as a molecular target in oral cancer., PMID:37589542
Ablation of KIF2C in Purkinje cells impairs metabotropic glutamate receptor trafficking and motor coordination in male mice., PMID:37431690
Transcriptomic profiling identifies differentially expressed genes and related pathways associated with wound healing and cuproptosis-related genes in Ganxi goats., PMID:37313229
Integrative bioinformatics and RNA sequencing based methodology results in the exploration of breast invasive carcinoma biomarkers., PMID:37303632
Integrated High-throughput Transcriptomic Data Identifies Survivin as a Potential Breast Cancer Therapeutic Biomarker., PMID:37194228
For research use only. Not for human or drug use.
