Catalog No.
YHD95401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asn56-Asp396
Predicted molecular weight
41.62 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P31415
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Calsequestrin, skeletal muscle isoform, CASQ, Calmitine, CASQ1, Calsequestrin-1
Deep-time gene expression shift reveals an ancient change in avian muscle phenotypes., PMID:40215240
ERG1A K+ channel increases intracellular calcium concentration through modulation of calsequestrin1 in C2C12 myotubes., PMID:40108273
Congenital tubular aggregates myopathy associated with central nervous system involvement: description of a case., PMID:40017288
Molecular determinants of skeletal muscle force loss in response to 5 days of dry immersion in human., PMID:39450600
CCDC78: Unveiling the Function of a Novel Gene Associated with Hereditary Myopathy., PMID:39273074
TAM-associated CASQ1 mutants diminish intracellular Ca2+ content and interfere with regulation of SOCE., PMID:39126637
Epididymal mRNA expression profiles for the protein disulfide isomerase gene family: Modulation by development and androgens., PMID:39087751
[Identification of a novel variant in a patient with Calsequestrin 1 related myopathy]., PMID:38818562
From Death to Life/Back to the Future: Detailed Premorbid Clinical and Family History Can Save Lives and Address the Final Diagnosis in Sudden Unexplained Deaths With Negative Autopsy., PMID:37796154
Structural Adaptation of the Excitation-Contraction Coupling Apparatus in Calsequestrin1-Null Mice during Postnatal Development., PMID:37626950
Acute aerobic exercise regulation of myocardial calcium homeostasis involves CASQ1, CASQ2, and TRDN., PMID:37589058
Space Omics and Tissue Response in Astronaut Skeletal Muscle after Short and Long Duration Missions., PMID:36835504
Store-operated calcium entry: From physiology to tubular aggregate myopathy., PMID:36608411
CASQ1-related myopathy: The first report from China and the literature review., PMID:36514469
Ablation of Calsequestrin-1, Ca2+ unbalance, and susceptibility to heat stroke., PMID:36311237
Inducible deletion of raptor and mTOR from adult skeletal muscle impairs muscle contractility and relaxation., PMID:36255030
Constitutive assembly of Ca2+ entry units in soleus muscle from calsequestrin knockout mice., PMID:36222861
I536T variant of RBM20 affects splicing of cardiac structural proteins that are causative for developing dilated cardiomyopathy., PMID:36198914
Oxygen Consumption and Basal Metabolic Rate as Markers of Susceptibility to Malignant Hyperthermia and Heat Stroke., PMID:36010545
Cardiac ion channel expression in the equine model - In-silico prediction utilising RNA sequencing data from mixed tissue samples., PMID:35880716
Critical role of Znhit1 for postnatal heart function and vacuolar cardiomyopathy., PMID:35167494
Genetic defects are common in myopathies with tubular aggregates., PMID:34908252
Calsequestrin 1 Is an Active Partner of Stromal Interaction Molecule 2 in Skeletal Muscle., PMID:34831044
Weighted gene co-expression network-based approach to identify key genes associated with anthracycline-induced cardiotoxicity and construction of miRNA-transcription factor-gene regulatory network., PMID:34732131
Differences in molecular phenotype in mouse and human hypertrophic cardiomyopathy., PMID:34162896
Functional Calsequestrin-1 Is Expressed in the Heart and Its Deficiency Is Causally Related to Malignant Hyperthermia-Like Arrhythmia., PMID:34162222
Evaluation of Candidate SNPs for Type 2 Diabetes Mellitus in Tohid Hospital of Sanandaj., PMID:34107625
Pathological mechanisms of vacuolar aggregate myopathy arising from a Casq1 mutation., PMID:33786938
Next-generation sequencing application to investigate skeletal muscle channelopathies in a large cohort of Italian patients., PMID:33573884
Calsequestrin: a well-known but curious protein in skeletal muscle., PMID:33288873
Luminal Ca2+ regulation of RyR1 Ca2+ channel leak activation and inactivation in sarcoplasmic reticulum membrane vesicles., PMID:33161753
Phylogenetic and biochemical analysis of calsequestrin structure and association of its variants with cardiac disorders., PMID:33093545
The structure of a calsequestrin filament reveals mechanisms of familial arrhythmia., PMID:33046906
ECC meets CEU-New focus on the backdoor for calcium ions in skeletal muscle cells., PMID:32851409
Calcium entry units (CEUs): perspectives in skeletal muscle function and disease., PMID:32812118
Pre-assembled Ca2+ entry units and constitutively active Ca2+ entry in skeletal muscle of calsequestrin-1 knockout mice., PMID:32761048
Calsequestrin Deletion Facilitates Hippocampal Synaptic Plasticity and Spatial Learning in Post-Natal Development., PMID:32751833
Calsequestrin, a key protein in striated muscle health and disease., PMID:32488451
Calsequestrins New Calcium Store Markers of Adult Zebrafish Cerebellum and Optic Tectum., PMID:32372920
Malignant Hyperthermia: A Clinical Review., PMID:31677658
Calcium Fluxes in Work-Related Muscle Disorder: Implications from a Rat Model., PMID:31662979
The Effect of Growth Restriction on Voluntary Physical Activity Engagement in Mice., PMID:31107349
Coding sequences of sarcoplasmic reticulum calcium ATPase regulatory peptides and expression of calcium regulatory genes in recurrent exertional rhabdomyolysis., PMID:30720217
Molecular parallelism in fast-twitch muscle proteins in echolocating mammals., PMID:30263960
The clinical spectrum of CASQ1-related myopathy., PMID:30258016
Gain-of-function mutations in STIM1 and ORAI1 causing tubular aggregate myopathy and Stormorken syndrome., PMID:30243034
Aerobic Training Prevents Heatstrokes in Calsequestrin-1 Knockout Mice by Reducing Oxidative Stress., PMID:29849896
Correlation between thyroidal and peripheral blood total T cells, CD8+ T cells, and CD8+ T- regulatory cells and T-cell reactivity to calsequestrin and collagen XIII in patients with Graves' ophthalmopathy., PMID:29787340
Skeletal Muscle-Specific Overexpression of PGC-1α Induces Fiber-Type Conversion through Enhanced Mitochondrial Respiration and Fatty Acid Oxidation in Mice and Pigs., PMID:29104506
Estrogens Protect Calsequestrin-1 Knockout Mice from Lethal Hyperthermic Episodes by Reducing Oxidative Stress in Muscle., PMID:29062464
For research use only. Not for human or drug use.
