Catalog No.
YHD38401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr266-Gln351
Predicted molecular weight
21.93 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P20265
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Brain-specific homeobox/POU domain protein 2, POU domain, class 3, transcription factor 2, Brain-2, OTF7, Oct-7, Nervous system-specific octamer-binding transcription factor N-Oct-3, Brn-2, Octamer-binding protein 7, OCT7, Octamer-binding transcription factor 7, POU3F2, BRN2, OTF-7
Effective therapeutic targeting of tumor lineage plasticity in neuroendocrine prostate cancer by BRD4 inhibitors., PMID:40370549
HOXDeRNA activates a cancerous transcription program and super enhancers via genome-wide binding., PMID:39383879
Conserved transcriptional regulation by BRN1 and BRN2 in neocortical progenitors drives mammalian neural specification and neocortical expansion., PMID:39271675
Loss of prohibitin 2 in Schwann cells dysregulates key transcription factors controlling developmental myelination., PMID:39215540
Identification of potential key ferroptosis- and autophagy-related genes in myelomeningocele through bioinformatics analysis., PMID:38660270
Loss of prohibitin 2 in Schwann cells dysregulates key transcription factors controlling developmental myelination., PMID:38562812
Xenopus Sox11 Partner Proteins and Functional Domains in Neurogenesis., PMID:38397232
RFX4 is an intrinsic factor for neuronal differentiation through induction of proneural genes POU3F2 and NEUROD1., PMID:38386071
The temporal and spatial pattern of leptin receptor-expressing cells in the developing mouse hypothalamus., PMID:38279680
LINC00662 promotes melanoma progression by competitively binding miR-107 and activating the β-catenin signaling pathway., PMID:38169586
Pan-primate studies of age and sex., PMID:37493860
Monoallelic intragenic POU3F2 variants lead to neurodevelopmental delay and hyperphagic obesity, confirming the gene's candidacy in 6q16.1 deletions., PMID:37207645
Identification of transcription factors related to diabetic tubulointerstitial injury., PMID:36978091
Integrin α3 Mediates Stemness and Invasion of Glioblastoma by Regulating POU3F2., PMID:36843258
Novel Variants of SOX4 in Patients with Intellectual Disability., PMID:36834931
Overexpression of POU3F2 promotes radioresistance in triple-negative breast cancer via Akt pathway activation., PMID:36797433
De novo human brain enhancers created by single-nucleotide mutations., PMID:36791193
Targeting CSC-related transcription factors by E3 ubiquitin ligases for cancer therapy., PMID:36371028
Integrative analysis of cell adhesion molecules in glioblastoma identified prostaglandin F2 receptor inhibitor (PTGFRN) as an essential gene., PMID:35690717
SOX12 Promotes Thyroid Cancer Cell Proliferation and Invasion by Regulating the Expression of POU2F1 and POU3F1., PMID:35619584
Identification of miRNA biomarkers for stomach adenocarcinoma., PMID:35578189
CircPOLR2A Promotes Proliferation and Impedes Apoptosis of Glioblastoma Multiforme Cells by Up-regulating POU3F2 to Facilitate SOX9 Transcription., PMID:35398178
Surgical resection of glioblastomas induces pleiotrophin-mediated self-renewal of glioblastoma stem cells in recurrent tumors., PMID:34964899
Schizophrenia is defined by cell-specific neuropathology and multiple neurodevelopmental mechanisms in patient-derived cerebral organoids., PMID:34789849
MUC1-C dictates neuroendocrine lineage specification in pancreatic ductal adenocarcinomas., PMID:34657147
The role of FOSL1 in stem-like cell reprogramming processes., PMID:34282187
STAG2 loss rewires oncogenic and developmental programs to promote metastasis in Ewing sarcoma., PMID:34129824
Establishment and characterization of a novel treatment-related neuroendocrine prostate cancer cell line KUCaP13., PMID:33960594
Behavioral sensitization induced by methamphetamine causes differential alterations in gene expression and histone acetylation of the prefrontal cortex in rats., PMID:33823794
Characterization of SALL2 Gene Isoforms and Targets Across Cell Types Reveals Highly Conserved Networks., PMID:33692826
Progenitor cell diversity in the developing mouse neocortex., PMID:33649223
Transcriptome-wide transmission disequilibrium analysis identifies novel risk genes for autism spectrum disorder., PMID:33539344
Integrin α3β1 Promotes Invasive and Metastatic Properties of Breast Cancer Cells through Induction of the Brn-2 Transcription Factor., PMID:33513758
Transcription factor POU3F2 regulates TRIM8 expression contributing to cellular functions implicated in schizophrenia., PMID:32929213
Identification of Target Genes in Hypertension and Left Ventricular Remodeling., PMID:32664164
Possible key microRNAs and corresponding molecular mechanisms for atrial fibrillation., PMID:32478689
Loss of CHD1 Promotes Heterogeneous Mechanisms of Resistance to AR-Targeted Therapy via Chromatin Dysregulation., PMID:32220301
MicroRNA-107 is a novel tumor suppressor targeting POU3F2 in melanoma., PMID:32169117
Unexpected High Levels of BRN2/POU3F2 Expression in Human Dermal Melanocytic Nevi., PMID:31881210
Reduced home cage and social activity in Pou3f2⊿ mice., PMID:31870549
Phosphorylation of Tet3 by cdk5 is critical for robust activation of BRN2 during neuronal differentiation., PMID:31807777
Combination of Chemical and Neurotrophin Stimulation Modulates Neurotransmitter Receptor Expression and Activity in Transdifferentiating Human Adipose Stromal Cells., PMID:31529274
Requirement of the transcription factor YB-1 for maintaining the stemness of cancer stem cells and reverting differentiated cancer cells into cancer stem cells., PMID:31375149
De Novo Variants Disturbing the Transactivation Capacity of POU3F3 Cause a Characteristic Neurodevelopmental Disorder., PMID:31303265
Inferring Regulatory Programs Governing Region Specificity of Neuroepithelial Stem Cells during Early Hindbrain and Spinal Cord Development., PMID:31302154
The Long Noncoding RNA Pnky Is a Trans-acting Regulator of Cortical Development In Vivo., PMID:31112699
BRN2 suppresses apoptosis, reprograms DNA damage repair, and is associated with a high somatic mutation burden in melanoma., PMID:30804224
Genome-Scale Transcriptional Regulatory Network Models of Psychiatric and Neurodegenerative Disorders., PMID:30772379
A GBM-like V-ATPase signature directs cell-cell tumor signaling and reprogramming via large oncosomes., PMID:30737083
The transcription factor POU3F2 regulates a gene coexpression network in brain tissue from patients with psychiatric disorders., PMID:30545964
For research use only. Not for human or drug use.
