Recombinant Human BABAM2 Protein, N-His

Catalog No.

YHK65901

Expression system

E. coli

Species

Homo sapiens (Human)

Protein length

Met1-Leu383

Predicted molecular weight

45.71 kDa

Nature

Recombinant

Endotoxin level

Please contact with the lab for this information.

Purity

>90% as determined by SDS-PAGE.

Accession

Q9NXR7

Applications

ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress

Form

Lyophilized

Storage buffer

Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.

Reconstitution

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

Shipping

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Alternative Names

BRE, BRCA1/BRCA2-containing complex subunit 45, BRCA1-A complex subunit BRE, BRISC and BRCA1-A complex member 2, Brain and reproductive organ-expressed protein, BABAM2, BRCC45

LncRNA BRE-AS1 regulates the JAK2/STAT3-mediated inflammatory activation via the miR-30b-5p/SOC3 axis in THP-1 cells., PMID:39468152

Babam2 negatively regulates osteoclastogenesis by interacting with Hey1 to inhibit Nfatc1 transcription., PMID:35864959

PPDPF Promotes the Progression and acts as an Antiapoptotic Protein in Non-Small Cell Lung Cancer., PMID:34975328

Bioinformatics analysis of long non-coding RNA-associated competing endogenous RNA network in schizophrenia., PMID:34952924

Identification of novel ALK rearrangements in gynecologic clear cell carcinoma., PMID:33034056

Beneficial Effects of Glucagon-Like Peptide-1 (GLP-1) in Diabetes-Induced Retinal Abnormalities: Involvement of Oxidative Stress., PMID:32927585

LncRNA BRE-AS1 acts as a tumor suppressor factor in bladder cancer via mediating STAT3., PMID:32495865

Periodic syndrome associated with the mutation of the receptor gene of the tumor necrosis factor (clinical case)., PMID:32248184

C-terminal BRE inhibits cellular proliferation and increases sensitivity to chemotherapeutic drugs of MLL-AF9 acute myeloid leukemia cells., PMID:31111759

Pharmacogenomics in epithelial ovarian cancer first-line treatment outcome: validation of GWAS-associated NRG3 rs1649942 and BRE rs7572644 variants in an independent cohort., PMID:30287910

Inositol-Requiring Enzyme 1-Mediated Downregulation of MicroRNA (miR)-146a and miR-155 in Primary Dermal Fibroblasts across Three TNFRSF1A Mutations Results in Hyperresponsiveness to Lipopolysaccharide., PMID:29467762

BRE/BRCC45 regulates CDC25A stability by recruiting USP7 in response to DNA damage., PMID:29416040

Other autoinflammatory disease genes in an FMF-prevalent population: a homozygous MVK mutation and a novel heterozygous TNFRSF1A mutation in two different Turkish families with clinical FMF., PMID:29148404

C-terminal BRE overexpression in 11q23-rearranged and t(8;16) acute myeloid leukemia is caused by intragenic transcription initiation., PMID:28871137

Bre Enhances Osteoblastic Differentiation by Promoting the Mdm2-Mediated Degradation of p53., PMID:28436570

BRE modulates granulosa cell death to affect ovarian follicle development and atresia in the mouse., PMID:28333135

Consumption of protein-enriched milk has minor effects on inflammation in older adults-A 12-week double-blind randomized controlled trial., PMID:28163108

Efficacy of anakinra in an adult patient with recurrent pericarditis and cardiac tamponade as initial manifestations of tumor necrosis factor receptor-associated periodic syndrome due to the R92Q TNFRSF1A variant., PMID:27990755

Over-expression of the long non-coding RNA HOTTIP inhibits glioma cell growth by BRE., PMID:27733185

BRE plays an essential role in preventing replicative and DNA damage-induced premature senescence., PMID:27001068

Genetic evaluation of BRCA1 associated a complex genes with triple-negative breast cancer susceptibility in Chinese women., PMID:26848770

BMP signalling differentially regulates distinct haematopoietic stem cell types., PMID:26282601

Anti-apoptotic protein BRE/BRCC45 attenuates apoptosis through maintaining the expression of caspase inhibitor XIAP in mouse Lewis lung carcinoma D122 cells., PMID:24395041

Silencing BRE expression in human umbilical cord perivascular (HUCPV) progenitor cells accelerates osteogenic and chondrogenic differentiation., PMID:23935848

Expression of the BRCA1 complex member BRE predicts disease free survival in breast cancer., PMID:22706632

Improved classification of MLL-AF9-positive acute myeloid leukemia patients based on BRE and EVI1 expression., PMID:22555662

Orphan receptor TR3 participates in cisplatin-induced apoptosis via Chk2 phosphorylation to repress intestinal tumorigenesis., PMID:22159226

High BRE expression predicts favorable outcome in adult acute myeloid leukemia, in particular among MLL-AF9-positive patients., PMID:21937695

NBA1/MERIT40 and BRE interaction is required for the integrity of two distinct deubiquitinating enzyme BRCC36-containing complexes., PMID:21282113

High BRE expression in pediatric MLL-rearranged AML is associated with favorable outcome., PMID:20861917

A unique pharmacophore for activation of the nuclear orphan receptor Nur77 in vivo and in vitro., PMID:20388790

BRE over-expression promotes growth of hepatocellular carcinoma., PMID:20035718

BMP2 accelerates the motility and invasiveness of gastric cancer cells via activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway., PMID:19835871

Differential expression of a novel gene BRE (TNFRSF1A modulator/BRCC45) in response to stress and biological signals., PMID:19757177

MERIT40 facilitates BRCA1 localization and DNA damage repair., PMID:19261748

Comparative proteomic analysis reveals differentially expressed proteins regulated by a potential tumor promoter, BRE, in human esophageal carcinoma cells., PMID:18756325

BRE is an antiapoptotic protein in vivo and overexpressed in human hepatocellular carcinoma., PMID:17704801

Global distribution of negative cofactor 2 subunit-alpha on human promoters., PMID:17548813

Comparative proteomic analysis reveals a function of the novel death receptor-associated protein BRE in the regulation of prohibitin and p53 expression and proliferation., PMID:16518872

Blocking BRE expression in Leydig cells inhibits steroidogenesis by down-regulating 3beta-hydroxysteroid dehydrogenase., PMID:15930177

BRE enhances in vivo growth of tumor cells., PMID:15582573

A death receptor-associated anti-apoptotic protein, BRE, inhibits mitochondrial apoptotic pathway., PMID:15465831

Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair., PMID:14636569

Expression of a conserved mouse stress-modulating gene, Bre: comparison with the human ortholog., PMID:14565866

Expression of human BRE in multiple isoforms., PMID:11676476

Differential expression of a stress-modulating gene, BRE, in the adrenal gland, in adrenal neoplasia, and in abnormal adrenal tissues., PMID:11259452

OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways., PMID:10660046

BRE: a modulator of TNF-alpha action., PMID:9737713

Identification of a brain- and reproductive-organs-specific gene responsive to DNA damage and retinoic acid., PMID:7826398

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Recombinant Human BABAM2 Protein, N-His.pdf