Catalog No.
YHD67101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg74-Gln182
Predicted molecular weight
15.31 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P25440
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Really interesting new gene 3 protein, KIAA9001, O27.1.1, BRD2, RING3, Bromodomain-containing protein 2
In-Cell Approach to Evaluate E3 Ligases for Use in Targeted Protein Degradation., PMID:40493706
Bromodomain and Extra-Terminal Family Proteins BRD2, BRD3, and BRD4 Contribute to H19-Dependent Transcriptional Regulation of Cell Adhesion Molecules, Modulating Metastatic Dissemination Program in Prostate Cancer., PMID:40407591
OsBIR3 maintains the homeostasis of OsBRI1, OsREM4.1, and Brd2 protein levels in brassinosteroid pathways in rice., PMID:40345159
Evaluation of Benzo[cd]indol-2(1H)-ones as Downstream Hedgehog Pathway Inhibitors., PMID:40227130
Inhibition of bromodomain and extra-terminal (BET) proteins with JQ1 exacerbates acetaminophen-induced hepatotoxicity by altering detoxification pathways and oxidative stress responses., PMID:40157625
Bromodomain-containing protein 2 gene polymorphism among patients with photosensitive epilepsy in Indonesia., PMID:40053300
Biochemical investigations using mass spectrometry to monitor JMJD6-catalysed hydroxylation of multi-lysine containing bromodomain-derived substrates., PMID:40046450
Proteomic analysis reveals chromatin remodeling as a potential therapeutical target in neuroblastoma., PMID:40011918
Helicobacter Pylori-induced BRD2 m6A modification sensitizes gastric cancer cells to chemotherapy by breaking FLIP/Caspase-8 homeostasis., PMID:39744419
Discovery of the First BRD4 Second Bromodomain (BD2)-Selective Inhibitors., PMID:39602227
Histone Modifications in the Anoxic Northern Crayfish, Faxonius virilis., PMID:39576345
RNA kinetics influence the response to transcriptional perturbation in leukaemia cell lines., PMID:39372038
Molecular mechanisms of ferroptosis in renal ischemia-reperfusion injury Investigated via bioinformatics analysis and animal experiments., PMID:39324174
Unraveling the Role of Bromodomain and Extra-Terminal Proteins in Human Uterine Leiomyosarcoma., PMID:39273015
BRD4-specific PROTAC inhibits basal-like breast cancer partially through downregulating KLF5 expression., PMID:39164524
SARS-CoV-2 E protein interacts with BRD2 and BRD4 SEED domains and alters transcription in a different way than BET inhibition., PMID:39066826
Mitochondrial Control of Proteasomal Psmb5 Drives the Differentiation of Tissue-Resident Memory T Cells in Patients with Rheumatoid Arthritis., PMID:39037181
YEATS domain-containing protein GAS41 regulates nuclear shape by working in concert with BRD2 and the mediator complex in colorectal cancer., PMID:38964523
Intrinsic signaling pathways modulate targeted protein degradation., PMID:38956052
Therapeutic targets for age-related macular degeneration: proteome-wide Mendelian randomization and colocalization analyses., PMID:38903171
mRNA Display in Cell Lysates Enables Identification of Cyclic Peptides Targeting the BRD3 Extraterminal Domain., PMID:38899853
Structural basis for double-stranded RNA recognition by SID1., PMID:38742627
Pharmacologic Targeting of Histone H3K27 Acetylation/BRD4-dependent Induction of ALDH1A3 for Early-phase Drug Tolerance of Gastric Cancer., PMID:38669046
BRD2-specific inhibitor, BBC0403, inhibits the progression of osteoarthritis pathogenesis in osteoarthritis-induced C57BL/6 male mice., PMID:38600628
BRD2 promotes antibody class switch recombination by facilitating DNA repair in collaboration with NIPBL., PMID:38567724
Bromodomain and Extraterminal Domain Protein 2 in Multiple Human Diseases., PMID:38565308
Phosphocreatine Promotes Epigenetic Reprogramming to Facilitate Glioblastoma Growth Through Stabilizing BRD2., PMID:38563585
Targeted protein degradation via intramolecular bivalent glues., PMID:38383787
Epigenetic regulators controlling osteogenic lineage commitment and bone formation., PMID:38341164
BRD2 and BRD3 genes independently evolved RNA structures to control unproductive splicing., PMID:38226395
CD146/MCAM links doxorubicin-induced epigenetic dysregulation to the impaired fatty acid transportation in H9c2 cardiomyoblasts., PMID:38100998
Bromodomain Proteins Epigenetically Regulate the Mitotically Associated lncRNA MANCR in Triple Negative Breast Cancer Cells., PMID:38073442
Discovery of a Drug-like, Natural Product-Inspired DCAF11 Ligand Chemotype., PMID:38036533
A Phase I/II Study of GSK525762 Combined with Fulvestrant in Patients with Hormone Receptor-positive/HER2-negative Advanced or Metastatic Breast Cancer., PMID:37992310
Investigating the expression of fertility-regulating LncRNAs in multiparous and uniparous Shal ewe's ovaries., PMID:37983732
BRD2 protects the rat H9C2 cardiomyocytes from hypoxia‑reoxygenation injury by targeting Nrf2/HO‑1 signaling pathway., PMID:37869639
YIV-818-A: a novel therapeutic agent in prostate cancer management through androgen receptor downregulation, glucocorticoid receptor inhibition, epigenetic regulation, and enhancement of apalutamide, darolutamide, and enzalutamide efficacy., PMID:37860121
Acetyl-methyllysine marks chromatin at active transcription start sites., PMID:37731000
Opposing Roles of SPOP Mutations in Human Prostate and Endometrial Cancers., PMID:37677121
Insights into the Mechanism of Curaxin CBL0137 Epigenetic Activity: The Induction of DNA Demethylation and the Suppression of BET Family Proteins., PMID:37629054
Cytoprotective, Cytotoxic and Cytostatic Roles of Autophagy in Response to BET Inhibitors., PMID:37628849
BRD4 PROTAC degrader MZ1 exhibits anti-B-cell acute lymphoblastic leukemia effects via targeting CCND3., PMID:37594294
Protein arginine methyltransferases PRMT1, PRMT4/CARM1 and PRMT5 have distinct functions in control of osteoblast differentiation., PMID:37593409
Differential responses of pulmonary vascular cells from PAH patients and controls to TNFα and the effect of the BET inhibitor JQ1., PMID:37516840
Glioblastoma Mesenchymal Transition and Invasion are Dependent on a NF-κB/BRD2 Chromatin Complex., PMID:37461511
Structural and biochemical insights into purine-based drug molecules in hBRD2 delineate a unique binding mode opening new vistas in the design of inhibitors of the BET family., PMID:37432115
Genome-wide association study identifies multiple HLA loci for sarcoidosis susceptibility., PMID:37399103
Uncovering the Kinetic Characteristics and Degradation Preference of PROTAC Systems with Advanced Theoretical Analyses., PMID:37388700
Novel genes associated with a placental phenotype in knockout mice also respond to cellular stressors in primary human trophoblasts., PMID:37331027
Targeting BET Proteins Decreases Hyaluronidase-1 in Pancreatic Cancer., PMID:37296612
For research use only. Not for human or drug use.
