Catalog No.
YHA20101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser46-Gly186
Predicted molecular weight
18.31 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O14503
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
DEC1, bHLHe40, Differentially expressed in chondrocytes protein 1, Class E basic helix-loop-helix protein 40, Class B basic helix-loop-helix protein 2, STRA13, SHARP2, SHARP-2, bHLHb2, Enhancer-of-split and hairy-related protein 2, BHLHB2, BHLHE40, Stimulated by retinoic acid gene 13 protein
BHLHE40 contributes to allergic asthma progression in mice through NRTN downregulation in macrophages., PMID:40467844
Icaritin induces paraptosis in hepatocellular carcinoma cells by targeting BHLHE40 via endoplasmic reticulum stress and mitochondrial dysfunction., PMID:40424981
BHLHE40-mediated RGS16 upregulation: a driver propelling gastric cancer progression via ferroptosis suppression., PMID:40413527
BHLHE40-mediated upregulation of CAV1 decreases the radiosensitivity of nasopharyngeal carcinoma., PMID:40387185
Circadian rhythm and aryl hydrocarbon receptor crosstalk in bone marrow adipose tissue and implications in leukemia., PMID:40350529
Integrated analysis of scRNA-seq and bulk RNA-seq data identifies BHLHE40 as a key gene in pancreatic cancer progression and gemcitabine resistance., PMID:40250076
Identification of BHLHE40-Expressing CD4+ T Cells Producing GM-CSF in Rheumatoid Arthritis., PMID:40223427
An Assessment of BHLHE40 Transcription Factor Level and its Target Cytokines in Patients with Rheumatoid Arthritis., PMID:39917914
[Knockdown of BHLHE40 inhibits the proliferation, migration, invasion and PI3K/AKT signaling activity of osteosarcoma cells]., PMID:39799423
Functional circuits of LYL1 controlled by supraphysiological androgen in prostate cancer cells to regulate cell senescence., PMID:39668349
BHLHE40 regulates microglia polarization after spinal cord injury via the NF-κB pathway., PMID:39586332
BHLHE40-mediated transcriptional activation of GRIN2D in gastric cancer is involved in metabolic reprogramming., PMID:39546079
Differential chromatin accessibility and transcriptional dynamics define breast cancer subtypes and their lineages., PMID:39478117
Comparing neoantigen cancer vaccines and immune checkpoint therapy unveils an effective vaccine and anti-TREM2 macrophage-targeting dual therapy., PMID:39446585
Treatment of acute pharyngitis in rats with season tea decoctions from traditional Chinese medicine through a synergistic and subtle regulation of ARNTL and BHLHE40., PMID:39389396
Computational Analyses Reveal Deregulated Clock Genes Associated with Breast Cancer Development in Night Shift Workers., PMID:39201344
CREG1 attenuates doxorubicin-induced cardiotoxicity by inhibiting the ferroptosis of cardiomyocytes., PMID:39094399
Bhlhe40 Regulates Proliferation and Angiogenesis in Mouse Embryoid Bodies under Hypoxia., PMID:39062912
Epigenetic maintenance of adult neural stem cell quiescence in the mouse hippocampus via Setd1a., PMID:38971831
The clock gene BHLHE40 and atypical CCNG2 control androgen-induced cellular senescence as a novel tumor suppressive pathway in prostate cancer., PMID:38902772
Melatonin inhibits circadian gene DEC1 and TLR2/MyD88/NF-κB signaling pathway to alleviate renal injury in type 2 diabetic mice., PMID:38896283
IGF-II regulates lysyl oxidase propeptide and mediates its effects in part via basic helix-loop-helix E40., PMID:38852924
BHLHE40 Regulates Myeloid Cell Polarization through IL-10-Dependent and -Independent Mechanisms., PMID:38683120
DEC1 is involved in circadian rhythm disruption-exacerbated pulmonary fibrosis., PMID:38671456
Single-Cell and Spatial Transcriptome Profiling Identifies the Transcription Factor BHLHE40 as a Driver of EMT in Metastatic Colorectal Cancer., PMID:38657117
Bhlhe40 Promotes CD4+ T Helper 1 Cell and Suppresses T Follicular Helper Cell Differentiation during Viral Infection., PMID:38619295
Construction of a prognostic model with CAFs for predicting the prognosis and immunotherapeutic response of lung squamous cell carcinoma., PMID:38520221
BHLHE40/41 regulate microglia and peripheral macrophage responses associated with Alzheimer's disease and other disorders of lipid-rich tissues., PMID:38448474
Bhlhe40 deficiency attenuates LPS-induced acute lung injury through preventing macrophage pyroptosis., PMID:38402153
Circadian Rhythm Alteration of the Core Clock Genes and the Lipid Metabolism Genes Induced by High-Fat Diet (HFD) in the Liver Tissue of the Chinese Soft-Shelled Turtle (Trionyx sinensis)., PMID:38397147
Large-scale integrative analysis of juvenile idiopathic arthritis for new insight into its pathogenesis., PMID:38336809
The BHLHE40‒PPM1F‒AMPK pathway regulates energy metabolism and is associated with the aggressiveness of endometrial cancer., PMID:38301894
Reanalysis and validation of the transcriptional pleural fluid signature in pleural tuberculosis., PMID:38288122
BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against Chlamydia., PMID:38271477
Discovery of Transcription Factors Involved in the Maintenance of Resident Vascular Endothelial Stem Cell Properties., PMID:38247234
Empagliflozin ameliorates vascular calcification in diabetic mice through inhibiting Bhlhe40-dependent NLRP3 inflammasome activation., PMID:38172306
Systematic single cell RNA sequencing analysis reveals unique transcriptional regulatory networks of Atoh1-mediated hair cell conversion in adult mouse cochleae., PMID:38079436
BHLHE40 Inhibits Ferroptosis in Pancreatic Cancer Cells via Upregulating SREBF1., PMID:38064101
LncRNA H19 Influences Cellular Activities via the miR-454-3p/BHLHE40 Axis in Anaplastic Thyroid Carcinoma., PMID:38052232
BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against Chlamydia., PMID:37961221
BHLHE40 Mediates Cross-Talk between Pathogenic TH17 Cells and Myeloid Cells during Experimental Autoimmune Encephalomyelitis., PMID:37934060
Mechanism of transforming growth factor-β1 induce renal fibrosis based on transcriptome sequencing analysis., PMID:37916309
Effect of Hyperbaric Oxygen and Inflammation on Human Gingival Mesenchymal Stem/Progenitor Cells., PMID:37887323
Unraveling T-cell Exhaustion: Genetic Screening Meets In Vitro Modeling., PMID:37855668
Bhlhe40 limits early IL-10 production from CD4+ T cells during Plasmodium yoelii 17X infection., PMID:37843306
Cutting Edge: STAT4 Promotes Bhlhe40 Induction to Drive Protective IFN-γ from NK Cells during Viral Infection., PMID:37830760
BHLHE40, a potential immune therapy target, regulated by FGD5-AS1/miR-15a-5p in pancreatic cancer., PMID:37773521
Islet-autoreactive CD4+ T cells are linked with response to alefacept in type 1 diabetes., PMID:37751304
Expression of circadian regulatory genes is dysregulated by increased cytokine production in mice subjected to concomitant intestinal injury and parenteral nutrition., PMID:37647292
A mutator-derived prognostic eRNA signature provides insight into the pathogenesis of breast cancer., PMID:37611728
For research use only. Not for human or drug use.
