Catalog No.
YHB36001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Phe225
Predicted molecular weight
28.29 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O75934
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
DNA amplified in mammary carcinoma 1 protein, BCAS2, DAM1, Breast carcinoma-amplified sequence 2, Pre-mRNA-splicing factor SPF27, Spliceosome-associated protein SPF 27
BCAS2 promotes primitive hematopoiesis by sequestering β-catenin within the nucleus., PMID:40511787
BCAS2 and hnRNPH1 orchestrate alternative splicing for DNA double-strand break repair and synapsis in meiotic prophase I., PMID:39520542
Splicing factor SRSF1 is essential for homing of precursor spermatogonial stem cells in mice., PMID:38271475
BCAS2 regulates oocyte meiotic prophase I by participating in mRNA alternative splicing., PMID:38085152
Molecular characterization, expression patterns and cellular localization of BCAS2 gene in male Hezuo pig., PMID:37901468
BCAS2 Participates in Insulin Synthesis and Secretion via mRNA Alternative Splicing in Mice., PMID:37820033
Single-cell proteo-genomic reveals a comprehensive map of centrosome-associated spliceosome components., PMID:37250316
BCAS2 regulates granulosa cell survival by participating in mRNA alternative splicing., PMID:37248466
Circ_002363 is regulated by the RNA binding protein BCAS2 and inhibits neodymium oxide nanoparticle-induced DNA damage by non-homologous end-joining repair., PMID:36526188
Molecular dissection of a hyper-aggressive CBFB-MYH11/FLT3-ITD-positive acute myeloid leukemia., PMID:35794567
Analysis of estrogen-regulated enhancer RNAs identifies a functional motif required for enhancer assembly and gene expression., PMID:35705040
Pannexin 1 drives efficient epithelial repair after tissue injury., PMID:35559667
Breast carcinoma-amplified sequence 2 regulates adult neurogenesis via β-catenin., PMID:35410459
BCAS2 is involved in alternative splicing and mouse oocyte development., PMID:34972250
Circular RNA NEK6 contributes to the development of non-small-cell lung cancer by competitively binding with miR-382-5p to elevate BCAS2 expression at post-transcriptional level., PMID:34663267
Overexpression of a Pak Choi Gene, BcAS2, Causes Leaf Curvature in Arabidopsis thaliana., PMID:33467565
BCAS2, a protein enriched in advanced prostate cancer, interacts with NBS1 to enhance DNA double-strand break repair., PMID:32963349
Genome-Wide DNA Methylation Profiles in Community Members Exposed to the World Trade Center Disaster., PMID:32751422
Knockdown of long non-coding RNA plasmacytoma variant translocation 1 inhibits cell proliferation while promotes cell apoptosis via regulating miR-486-mediated CDK4 and BCAS2 in multiple myeloma., PMID:31900844
Highlighted role of VEGFA in follow up of celiac disease., PMID:31528310
BCAS2 Enhances Carcinogenic Effects of Estrogen Receptor Alpha in Breast Cancer Cells., PMID:30813351
BCAS2 is essential for hematopoietic stem and progenitor cell maintenance during zebrafish embryogenesis., PMID:30482793
Prp19/Pso4 Is an Autoinhibited Ubiquitin Ligase Activated by Stepwise Assembly of Three Splicing Factors., PMID:29547724
miR-486 functions as a tumor suppressor in esophageal cancer by targeting CDK4/BCAS2., PMID:29115564
Constrained release of lamina-associated enhancers and genes from the nuclear envelope during T-cell activation facilitates their association in chromosome compartments., PMID:28424353
BCAS2 is involved in alternative mRNA splicing in spermatogonia and the transition to meiosis., PMID:28128212
Conditional Knockout of Breast Carcinoma Amplified Sequence 2 (BCAS2) in Mouse Forebrain Causes Dendritic Malformation via β-catenin., PMID:27713508
Novel IGH and MYC Translocation Partners in Diffuse Large B-Cell Lymphomas., PMID:27356265
The molecular architecture of the Dam1 kinetochore complex is defined by cross-linking based structural modelling., PMID:26560693
Maternal BCAS2 protects genomic integrity in mouse early embryonic development., PMID:26428007
BCAS2 interacts with HSF4 and negatively regulates its protein stability via ubiquitination., PMID:26319152
BCAS2 Regulates Delta-Notch Signaling Activity through Delta Pre-mRNA Splicing in Drosophila Wing Development., PMID:26091239
BCAS2 promotes prostate cancer cells proliferation by enhancing AR mRNA transcription and protein stability., PMID:25461807
ERRβ signalling through FST and BCAS2 inhibits cellular proliferation in breast cancer cells., PMID:24667650
The PSO4 protein complex associates with replication protein A (RPA) and modulates the activation of ataxia telangiectasia-mutated and Rad3-related (ATR)., PMID:24443570
Common genetic variants on 1p13.2 associate with risk of autism., PMID:24189344
The Prp19 complex directly functions in mitotic spindle assembly., PMID:24069358
BCAS2 is essential for Drosophila viability and functions in pre-mRNA splicing., PMID:23249746
Chromatin signaling to kinetochores: transregulation of Dam1 methylation by histone H2B ubiquitination., PMID:21884933
The Dam1 ring binds to the E-hook of tubulin and diffuses along the microtubule., PMID:21169562
Breast cancer amplified sequence 2, a novel negative regulator of the p53 tumor suppressor., PMID:19903847
Potentiation of estrogen receptor transcriptional activity by breast cancer amplified sequence 2., PMID:15694360
Amplification of the BCAS2 gene at chromosome 1p13.3-21 in human primary breast cancer., PMID:12169396
Identification of a novel gene, DAM1, amplified at chromosome 1p13.3-21 region in human breast cancer cell lines., PMID:10403562
For research use only. Not for human or drug use.
