Catalog No.
YHF65201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
His72-Tyr426
Predicted molecular weight
43.10 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P78348
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ASIC1, Amiloride-sensitive cation channel 2, neuronal, BNaC2, Brain sodium channel 2, ACCN2, Acid-sensing ion channel 1, BNAC2
ASIC1a-Dependent Potentiation of Acid-Sensing Ion Channel Currents by Cyanide., PMID:40305197
Acid-sensing ion channel 1a promotes LPS-induced acute lung injury through the circRNA 18-658/miR-127-5p/TRIM72 axis., PMID:40279987
Lacking ASIC1a in ASIC4-positive amygdala/bed nucleus of the stria terminalis (BNST) neurons reduces anxiety and innate fear in mice., PMID:40264173
PFKM-Mediated Glycolysis: A Pathway for ASIC1 to Enhance Cell Survival in the Acidic Microenvironment of Liver Cancer., PMID:40149892
[Study on the mechanism of apoptosis mediated by acid sensitive ion channel 1 through extracellular signal regulation of kinase 5 signaling pathway and mitochondrial disorder pathway]., PMID:40148093
Two Amino Acid Substitutions Improve the Pharmacological Profile of the Snake Venom Peptide Mambalgin., PMID:40137874
Upregulation of Acid-Sensing Ion Channel 1a in the Anterior Cingulate Cortex by TNF-α/NF-κB Pathway Contributes to Diabetes-Related Pain., PMID:40131336
Sea anemone Cys-ladder peptide Ms13-1 induces a pain response as a positive modulator of acid-sensing ion channel 1a., PMID:39964805
Astrocytic Acid-Sensing Ion Channel 1a Contributes to the Development of Epileptic Cognitive Impairment., PMID:39858536
Inhibition of ASIC1a reduces ferroptosis in rheumatoid arthritis articular chondrocytes via the p53/NRF2/SLC7A11 pathway., PMID:39760183
Acidosis induces autophagic cell death through ASIC1-mediated Akt/mTOR signaling in HT22 neurons., PMID:39756784
Acid-sensing ion channel 1a promotes alcohol-associated liver disease in mice via regulating endoplasmic reticulum autophagy., PMID:39592735
Succinate dehydrogenase mediated ROS production contributes to ASIC1a-induced chondrocyte pyroptosis in rheumatoid arthritis., PMID:39586503
ASIC1a regulates airway epithelial cell pyroptosis in acute lung injury by NLRP3-Caspase1-GSDMD pathway., PMID:39549550
The Role of Acid-Sensing Ion Channel 1A (ASIC1A) in the Behavioral and Synaptic Effects of Oxycodone and Other Opioids., PMID:39519136
Mechanism of acid-sensing ion channel modulation by Hi1a., PMID:39446054
Modulation of Neurotransmission by Acid-Sensing Ion Channels., PMID:39287486
Proline substitutions in the ASIC1 β11-12 linker slow desensitization., PMID:39182166
A novel experimental mouse model of diabetic nonalcoholic steatohepatitis: A critical role for acid-sensitive Ion Channel 1a., PMID:39142252
Enhanced glycolysis causes extracellular acidification and activates acid-sensing ion channel 1a in hypoxic pulmonary hypertension., PMID:39104320
iMSC exosome delivers hsa-mir-125b-5p and strengthens acidosis resilience through suppression of ASIC1 protein in cerebral ischemia-reperfusion., PMID:39019215
Bone marrow monocytes and macrophages from mice lacking βENaC and ASIC2 have a reduced chemotactic migration response and polarization., PMID:39016176
Glutamate acts on acid-sensing ion channels to worsen ischaemic brain injury., PMID:38987597
Identification of the modulatory Ca2+-binding sites of acid-sensing ion channel 1a., PMID:38896086
Acid-sensing ion channel 1 in nucleus tractus solitarii neurons contributes to the enhanced CO2-stimulated cardiorespiratory effect in spontaneously hypertensive rats., PMID:38889841
Revealing molecular determinants governing mambalgin-3 pharmacology at acid-sensing ion channel 1 variants., PMID:38880807
Cholestane-3β,5α,6β-Triol Inhibits Acid-Sensing Ion Channels and Reduces Acidosis-Mediated Ischemic Brain Injury., PMID:38660789
Functional expression of the proton sensors ASIC1a, TMEM206, and OGR1 together with BKCa channels is associated with cell volume changes and cell death under strongly acidic conditions in DAOY medulloblastoma cells., PMID:38627262
4-(Azolyl)-Benzamidines as a Novel Chemotype for ASIC1a Inhibitors., PMID:38612396
The funnel-web spider venom derived single knot peptide Hc3a modulates acid-sensing ion channel 1a desensitisation., PMID:38552850
Dynamic conformational changes of acid-sensing ion channels in different desensitizing conditions., PMID:38549370
ASIC1 promotes migration and invasion of hepatocellular carcinoma via the PRKACA/AP-1 signaling pathway., PMID:38306794
Molecular determinants of ASIC1 modulation by divalent cations., PMID:38282035
Inhibition of ASIC1a Improves Behavioral Recovery after Stroke., PMID:38233146
Transcriptomic profile of the mechanosensitive ion channelome in human cardiac fibroblasts., PMID:38158807
Acid-Sensing Ion Channels' Immunoreactivity in Nerve Profiles and Glomus Cells of the Human Carotid Body., PMID:38138991
Hemokinin-1 induces transcriptomic alterations in pain-related signaling processes in rat primary sensory neurons independent of NK1 tachykinin receptor activation., PMID:37965042
ASIC1/RIP1 accelerates atherosclerosis via disrupting lipophagy., PMID:37931656
ASIC1a affects hypothalamic signaling and regulates the daily rhythm of body temperature in mice., PMID:37591947
Automated Patch Clamp Screening of Amiloride and 5-N,N-Hexamethyleneamiloride Analogs Identifies 6-Iodoamiloride as a Potent Acid-Sensing Ion Channel Inhibitor., PMID:37260417
High-fidelity encoding of mechanostimuli by tactile food-sensing neurons requires an ensemble of ion channels., PMID:37119137
Ion channels in dry eye disease., PMID:37026252
Genetic or Pharmacological Ablation of Acid-Sensing Ion Channel 1a (ASIC1a) Is Not Neuroprotective in a Mouse Model of Spinal Cord Injury., PMID:36924276
DNMT1 involved in the analgesic effect of folic acid on gastric hypersensitivity through downregulating ASIC1 in adult offspring rats with prenatal maternal stress., PMID:36852448
Metabolic Characterization and Glyceraldehyde-3-Phosphate Dehydrogenase-Dependent Regulation of Epithelial Sodium Channels in hPheo1 Wild-type and SDHB Knockdown Cells., PMID:36763043
Identification of Novel Biomarkers for Abdominal Aortic Aneurysm Promoted by Obstructive Sleep Apnea., PMID:36739079
Segmental Upregulation of ASIC1 Channels in the Formalin Acute Pain Mouse Model., PMID:36558990
Acid-sensing ion channel 1a activates IKCa/SKCa channels and contributes to endothelium-dependent dilation., PMID:36484717
Estrogen antagonizes ASIC1a-induced chondrocyte mitochondrial stress in rheumatoid arthritis., PMID:36463203
Acid-sensitive ion channel 1a regulates TNF-α expression in LPS-induced acute lung injury via ERS-CHOP-C/EBPα signaling pathway., PMID:36403431
For research use only. Not for human or drug use.
