Catalog No.
YHK65801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met430-Pro628
Predicted molecular weight
24.81 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UBL3
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ASH2L, ASH2-like protein, Set1/Ash2 histone methyltransferase complex subunit ASH2, ASH2L1
ASH2L Deficiency in Smooth Muscle Drives Pulmonary Vascular Remodeling., PMID:39996311
The KMT2 complex protein ASH2L is required for meiotic prophase progression but dispensable for mitosis in differentiated spermatogonia., PMID:39992154
Assessment of PRMT6-dependent alternative splicing in pluripotent and differentiating NT2/D1 cells., PMID:39900436
ASH2L Mediates Epidermal Differentiation and Hair Follicle Morphogenesis through H3K4me3 Modification., PMID:38582368
lncCPSET1 acts as a scaffold for MLL2/COMPASS to regulate Bmp4 and promote the formation of chicken primordial germ cells., PMID:38551742
Functional role of Ash2l in oxLDL induced endothelial dysfunction and atherosclerosis., PMID:38280036
Sequential deregulation of histone marks, chromatin accessibility and gene expression in response to PROTAC-induced degradation of ASH2L., PMID:38114530
ASH2L, Core Subunit of H3K4 Methylation Complex, Regulates Amelogenesis., PMID:37990471
Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival., PMID:37974198
ASH2L-mediated H3K4me3 drives diabetic nephropathy through HIPK2 and Notch1 pathway., PMID:37879562
ASH2L regulates postnatal neurogenesis through Onecut2-mediated inhibition of TGF-β signaling pathway., PMID:37433907
CSTF2T facilitates pancreatic adenocarcinoma growth and metastasis by elevating H3K4Me1 methylation of CALB2 via ASH2L., PMID:37287122
ASH2L, a COMPASS core subunit, is involved in the cell invasion and migration of triple-negative breast cancer cells through the epigenetic control of histone H3 lysine 4 methylation., PMID:37262949
Induction of Hibernation and Changes in Physiological and Metabolic Indices in Pelodiscus sinensis., PMID:37237532
Characteristics and Prognosis of 8p11.23-Amplified Squamous Lung Carcinomas., PMID:36902501
ASH2L Controls Ureteric Bud Morphogenesis through the Regulation of RET/GFRA1 Signaling Activity in a Mouse Model., PMID:36758123
Hierarchical assembly of the MLL1 core complex regulates H3K4 methylation and is dependent on temperature and component concentration., PMID:36623730
ASH2L Aggravates Fibrosis and Inflammation through HIPK2 in High Glucose-Induced Glomerular Mesangial Cells., PMID:36553510
Loss of the Ash2l subunit of histone H3K4 methyltransferase complexes reduces chromatin accessibility at promoters., PMID:36513698
Ash2l, an obligatory component of H3K4 methylation complexes, regulates neural crest development., PMID:36162552
Structural basis for product specificities of MLL family methyltransferases., PMID:36108631
Multistate structures of the MLL1-WRAD complex bound to H2B-ubiquitinated nucleosome., PMID:36095189
Dissecting the Kinetic Mechanism of Human Lysine Methyltransferase 2D and Its Interactions with the WRAD2 Complex., PMID:36070615
DPY30 acts as an ASH2L-specific stabilizer to stimulate the enzyme activity of MLL family methyltransferases on different substrates., PMID:36065180
Single-Cell Transcriptome Analysis Defines Expression of Kabuki Syndrome-Associated KMT2D Targets and Interacting Partners., PMID:35992033
A comprehensive analysis of LMO2 pathogenic regulatory profile during T-lineage development and leukemic transformation., PMID:35851847
Induction of senescence upon loss of the Ash2l core subunit of H3K4 methyltransferase complexes., PMID:35819198
The Ash2l SDI Domain Is Required to Maintain the Stability and Binding of DPY30., PMID:35563756
The low-complexity domains of the KMT2D protein regulate histone monomethylation transcription to facilitate pancreatic cancer progression., PMID:34758724
Structure, Activity and Function of the MLL2 (KMT2B) Protein Lysine Methyltransferase., PMID:34440566
Exploration of the Activation Mechanism of the Epigenetic Regulator MLL3: A QM/MM Study., PMID:34356675
Mechanism for DPY30 and ASH2L intrinsically disordered regions to modulate the MLL/SET1 activity on chromatin., PMID:34012049
CircASH2L facilitates tumor-like biologic behaviours and inflammation of fibroblast-like synoviocytes via miR-129-5p/HIPK2 axis in rheumatoid arthritis., PMID:33964939
Smyd1 Orchestrates Early Heart Development Through Positive and Negative Gene Regulation., PMID:33869215
Distinct kinetic mechanisms of H3K4 methylation catalyzed by MLL3 and MLL4 core complexes., PMID:33823156
The COMPASS-like complex modulates fungal development and pathogenesis by regulating H3K4me3-mediated targeted gene expression in Magnaporthe oryzae., PMID:33559339
ASH2L drives proliferation and sensitivity to bleomycin and other genotoxins in Hodgkin's lymphoma and testicular cancer cells., PMID:33257682
Restoring MLL reactivates latent tumor suppression-mediated vulnerability to proteasome inhibitors., PMID:32733069
Crystal Structure of MLL2 Complex Guides the Identification of a Methylation Site on P53 Catalyzed by KMT2 Family Methyltransferases., PMID:32697937
An organoid-based drug screening identified a menin-MLL inhibitor for endometrial cancer through regulating the HIF pathway., PMID:32632269
H2B ubiquitylation enhances H3K4 methylation activities of human KMT2 family complexes., PMID:32365172
Suppression of Mll1-Complex by Stat3/Cebpβ-Induced miR-21a/21b/181b Maintains the Accumulation, Homeostasis, and Immunosuppressive Function of Polymorphonuclear Myeloid-Derived Suppressor Cells., PMID:32358019
The complex activities of the SET1/MLL complex core subunits in development and disease., PMID:32302696
ASH2L is involved in promotion of endometrial cancer progression via upregulation of PAX2 transcription., PMID:32279431
Cancer-derived UTX TPR mutations G137V and D336G impair interaction with MLL3/4 complexes and affect UTX subcellular localization., PMID:32071397
ASH2L-Promoted HOXC8 Gene Expression Plays a Role in Mixed Lineage Leukemia-Rearranged Acute Leukemia., PMID:32021283
The plasma peptides of breast versus ovarian cancer., PMID:31889940
Glucocorticoids uncover a critical role for ASH2L on BCL-X expression regulation in leukemia cells., PMID:31870784
Cryo-EM structure of the human MLL1 core complex bound to the nucleosome., PMID:31804488
Circ-ASH2L promotes tumor progression by sponging miR-34a to regulate Notch1 in pancreatic ductal adenocarcinoma., PMID:31718694
For research use only. Not for human or drug use.
