Catalog No.
YHA56801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser54-Lys181
Predicted molecular weight
17.42 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O15539
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
RGS5, Regulator of G-protein signaling 5
3D Histology visualizing hypoxia-induced upregulation of N-terminal cysteine using de novo fluorophore generation., PMID:40054059
A pan-cancer analysis of the oncogenic and immunological roles of RGS5 in clear cell renal cell carcinomas based on in vitro experiment validation., PMID:39985100
Single-cell atlas of human pancreatic islet and acinar endothelial cells in health and diabetes., PMID:39915484
Germline deletion of Rgs2 and/or Rgs5 in male mice does not exacerbate left ventricular remodeling induced by subchronic isoproterenol infusion., PMID:39746869
Cancer-associated fibroblast subtypes modulate the tumor-immune microenvironment and are associated with skin cancer malignancy., PMID:39516494
Identification and experimental validation of hub genes underlying depressive-like behaviors induced by chronic social defeat stress., PMID:39469623
RGS5+ lymphatic endothelial cells facilitate metastasis and acquired drug resistance of breast cancer through oxidative stress-sensing mechanism., PMID:39306871
The enzymatic oxygen sensor cysteamine dioxygenase binds its protein substrates through their N-termini., PMID:39122008
Cobalt(II)-Substituted Cysteamine Dioxygenase Oxygenation Proceeds through a Cobalt(III)-Superoxo Complex., PMID:38941563
The mechanism of RGS5 regulating gastric cancer mismatch repair protein., PMID:38860604
Age-Dependent RGS5 Loss in Pericytes Induces Cardiac Dysfunction and Fibrosis., PMID:38563133
Phosphodiesterases Mediate the Augmentation of Myogenic Constriction by Inhibitory G Protein Signaling and is Negatively Modulated by the Dual Action of RGS2 and 5., PMID:38486977
RGS4 controls airway hyperresponsiveness through GAP-independent mechanisms., PMID:38432633
Single-Cell Transcriptome Analysis Identified Core Genes and Transcription Factors in Mesenchymal Cell Differentiation during Liver Cirrhosis., PMID:38420807
Implication of biosignatures in the progression of endometriosis., PMID:38237401
RGS5 maintaining vascular homeostasis is altered by the tumor microenvironment., PMID:37986113
Integrated analysis of single-cell RNA-seq and bulk RNA-seq unravels the heterogeneity of cancer-associated fibroblasts in TNBC., PMID:37963845
Identification of cancer-associated fibroblasts signature for predicting the prognosis and immunotherapy response in hepatocellular carcinoma., PMID:37960718
RGS5 as a Biomarker of Pericytes, Involvement in Vascular Remodeling and Pulmonary Arterial Hypertension., PMID:37881333
Listeria-based vaccination against the pericyte antigen RGS5 elicits anti-vascular effects and colon cancer protection., PMID:37781234
RGS5 augments astrocyte activation and facilitates neuroinflammation via TNF signaling., PMID:37674228
Lnc‑RGS5 sponges miR‑542‑5p to promote FoxM1/VEGFA signaling and breast cancer cell proliferation., PMID:37594134
Sox10 escalates vascular inflammation by mediating vascular smooth muscle cell transdifferentiation and pyroptosis in neointimal hyperplasia., PMID:37481722
Defibrotide mitigates endothelial cell injury induced by plasmas from patients with COVID-19 and related vasculopathies., PMID:37001283
Resmetirom Ameliorates NASH-Model Mice by Suppressing STAT3 and NF-κB Signaling Pathways in an RGS5-Dependent Manner., PMID:36982915
Molecular Regulation of the Response of Brain Pericytes to Hypoxia., PMID:36982744
Mural cell composition and functional analysis in the healing process of human gingiva from periodontal intrabony defects., PMID:36947913
Lineage Tracing of RGS5-CreER-Labeled Cells in Long Bones During Homeostasis and Injury., PMID:36888549
Tracing G-Protein-Mediated Contraction and Relaxation in Vascular Smooth Muscle Cell Spheroids., PMID:36611924
A novel necroptosis-related lncRNA based signature predicts prognosis and response to treatment in cervical cancer., PMID:36561319
Gene expression meta-analysis in patients with schizophrenia reveals up-regulation of RGS2 and RGS16 in Brodmann Area 10., PMID:36443250
RGS5: a novel role as a hypoxia-responsive protein that suppresses chemokinetic and chemotactic migration in brain pericytes., PMID:36111549
Hypoxia-induced miR-182-5p regulates vascular smooth muscle cell phenotypic switch by targeting RGS5., PMID:35946384
Single-Cell Transcriptomic Analysis of the Mouse Pancreas: Characteristic Features of Pancreatic Ductal Cells in Chronic Pancreatitis., PMID:35741777
Implications of regulator of G-protein signaling 5 expression in the pathogenesis of primary and secondary hyperparathyroidism., PMID:35681135
Dual loss of regulator of G protein signaling 2 and 5 exacerbates ventricular myocyte arrhythmias and disrupts the fine-tuning of Gi/o signaling., PMID:35661621
miR-320a Targeting RGS5 Aggravates Atherosclerosis by Promoting Migration and Proliferation of ox-LDL-Stimulated Vascular Smooth Muscle Cells., PMID:35522176
Regulator of G-Protein Signaling 5 Protein Deficiency Differentially Influences Blood Pressure, Vascular and Behavioral Effects in Aged Male Mice., PMID:35384894
NLGP regulates RGS5-TGFβ axis to promote pericyte-dependent vascular normalization during restricted tumor growth., PMID:35363396
A regulator of G protein signaling 5 marked subpopulation of vascular smooth muscle cells is lost during vascular disease., PMID:35320283
The Role and Mechanism of SIRT6 in Regulating Phenotype Transformation of Vascular Smooth Muscle Cells in Abdominal Aortic Aneurysm., PMID:35035519
Single-cell RNA-seq recognized the initiator of epithelial ovarian cancer recurrence., PMID:34992217
Dendritic cell vaccines targeting tumor blood vessel antigens in combination with dasatinib induce therapeutic immune responses in patients with checkpoint-refractory advanced melanoma., PMID:34782430
NKX2-1 re-expression induces cell death through apoptosis and necrosis in dedifferentiated thyroid carcinoma cells., PMID:34748583
Developmental role of PHD2 in the pathogenesis of pseudohypoxic pheochromocytoma., PMID:34658364
RGS5 Determines Neutrophil Migration in the Acute Inflammatory Phase of Bleomycin-Induced Lung Injury., PMID:34502263
RGS5 Attenuates Baseline Activity of ERK1/2 and Promotes Growth Arrest of Vascular Smooth Muscle Cells., PMID:34359918
Ex Vivo Intact Tissue Analysis Reveals Alternative Calcium-sensing Behaviors in Parathyroid Adenomas., PMID:34272844
Neuroprotective effects of four different fluids on cerebral ischaemia/reperfusion injury in rats through stabilization of the blood-brain barrier., PMID:34258805
Integration of NRP1, RGS5, and FOXM1 expression, and tumour necrosis, as a postoperative prognostic classifier based on molecular subtypes of clear cell renal cell carcinoma., PMID:34212534
For research use only. Not for human or drug use.
