Catalog No.
YHK65401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp1773-Asp2121
Predicted molecular weight
39.72 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8IZY2
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Macrophage ABC transporter, ABCA-SSN, ATP-binding cassette sub-family A member 7, Autoantigen SS-N, Phospholipid-transporting ATPase ABCA7, ABCA7
Association of Alzheimer's-Related Gene Variants with Autism Spectrum Disorder: A Case-Control Study in an Iraqi Cohort., PMID:40327194
Genetic and environmental risk factors for dementia in African adults: A systematic review., PMID:40289851
Computational and functional prioritization identifies genes that rescue behavior and reduce tau protein in fly and human cell models of Alzheimer disease., PMID:40215969
Human sensory-like neuron surfaceome analysis., PMID:40173182
Generation of a homozygous ABCA7 knockout cell line (AHMUCNi002-A) in human iPSCs using CRISPR/Cas9., PMID:40157320
The relationship between Alzheimer's disease and intracerebral hemorrhage based on Mendelian randomization., PMID:40151895
Neuronal ABCA7 deficiency aggravates mitochondrial dysfunction and neurodegeneration in Alzheimer's disease., PMID:40145325
Integrated Analysis of WES and scRNA-Seq Data Reveals the Genetic Basis of Immune Dysregulation in Unexplained Recurrent Pregnancy Loss., PMID:40066928
Genetic association study between rs2234253 (p.T96K) variant of TREM2 and Alzheimer's disease in a Tunisian population., PMID:40043316
ABCA1-mediated nascent HDL formation is precisely regulated by the plasma membrane cholesterol., PMID:39978466
The impact of rare genetic variants on Alzheimer disease., PMID:39905212
Alzheimer's disease risk ABCA7 p.A696S variant disturbs the microglial response to amyloid pathology in mice., PMID:39880319
The ABC transporter A7 modulates neuroinflammation via NLRP3 inflammasome in Alzheimer's disease mice., PMID:39871385
Structural insights into human ABCA7-mediated lipid transport., PMID:39826550
Haploinsufficiency and Alzheimer's Disease: The Possible Pathogenic and Protective Genetic Factors., PMID:39596030
The association of ABC proteins with multidrug resistance in cancer., PMID:39571941
Consistent genes associated with structural changes in clinical Alzheimer's disease spectrum., PMID:39554844
Alzheimer's Disease and Effects of ABCA7 Polymorphisms: A Review., PMID:39344232
ABCA7-dependent induction of neuropeptide Y is required for synaptic resilience in Alzheimer's disease through BDNF/NGFR signaling., PMID:39216475
Identification of Genetic Variants in Progressive Supranuclear Palsy in Southeast Asia., PMID:39149795
Very low levels of ABCA7 in the cerebrum and Alzheimer's disease onset between the ages of 60 and 80 independently of APOE., PMID:38900184
Emerging Role of ABC Transporters in Glia Cells in Health and Diseases of the Central Nervous System., PMID:38727275
Genetic Screening of Patients with Sporadic Alzheimer's Disease and Frontotemporal Lobar Degeneration in the Chinese Population., PMID:38701145
Involvement of transposable elements in Alzheimer's disease pathogenesis., PMID:38680184
The ABC's of Alzheimer risk gene ABCA7., PMID:38556850
Utilizing Machine Learning to Identify Biomarkers of Endoplasmic Reticulum Stress and Analyze Immune Cell Infiltration in Parkinson's Disease., PMID:38521829
The Abca7V1613M variant reduces Aβ generation, plaque load, and neuronal damage., PMID:38506634
Gegen Qinlian Decoction Modulates Atherosclerosis and Lipid Metabolism Through Cellular Interplay and Signaling Pathways., PMID:38486386
Lessons from genetic studies in Alzheimer disease., PMID:38429159
Generation of an induced pluripotent stem cell line (UMi043-A) from an African American patient with Alzheimer's disease carrying an ABCA7 deletion (p.Arg578Alafs)., PMID:38422817
Assessment of Mendelian and risk-factor genes in Alzheimer disease: A prospective nationwide clinical utility study and recommendations for genetic screening., PMID:38281098
Alzheimer's Disease: Models and Molecular Mechanisms Informing Disease and Treatments., PMID:38247923
Knowledge domains and emerging trends of Genome-wide association studies in Alzheimer's disease: A bibliometric analysis and visualization study from 2002 to 2022., PMID:38241287
14-Week exercise training modifies the DNA methylation levels at gene sites in non-Alzheimer's disease women aged 50 to 70 years., PMID:38232788
ABCA7 deficiency causes neuronal dysregulation by altering mitochondrial lipid metabolism., PMID:38135757
CSF biomarker analysis of ABCA7 mutation carriers suggests altered APP processing and reduced inflammatory response., PMID:37946268
Patient with PSEN1 Glu318Gly and Other Possible Disease Risk Mutations, Diagnosed with Early Onset Alzheimer's Disease., PMID:37895139
Structural Variation Detection and Association Analysis of Whole-Genome-Sequence Data from 16,905 Alzheimer's Diseases Sequencing Project Subjects., PMID:37886469
Association of Blood-Based DNA Methylation Markers With Late-Onset Alzheimer Disease: A Potential Diagnostic Approach., PMID:37827850
A Multiplexed Urinary Biomarker Panel Has Potential for Alzheimer's Disease Diagnosis Using Targeted Proteomics and Machine Learning., PMID:37762058
Structural Variation Detection and Association Analysis of Whole-Genome-Sequence Data from 16,905 Alzheimer's Diseases Sequencing Project Subjects., PMID:37745545
Down-Regulation of ABCA7 in Human Microglia, Astrocyte and THP-1 Cell Lines by Cholesterol Depletion, IL-1β and TNFα, or PMA., PMID:37681876
A plasma protein signature associated with cognitive function in men without severe cognitive impairment., PMID:37658429
Comprehensive genetic screening of early-onset dementia patients in an Austrian cohort-suggesting new disease-contributing genes., PMID:37330543
ABCA7-Associated Clinical Features and Molecular Mechanisms in Alzheimer's Disease., PMID:37322288
Aberrant DNA Methylation, Expression, and Occurrence of Transcript Variants of the ABC Transporter ABCA7 in Breast Cancer., PMID:37296582
An Indian Young-onset Dementia With Parkinsonism With Double Heterozygous Mutations in ABCA7 and PRKN Identified Through Whole-exome Sequencing., PMID:37253124
High-Quality Sleep Mitigates ABCA7-Related Generalization Deficits in Healthy Older African Americans., PMID:37212111
Large multi-ethnic genetic analyses of amyloid imaging identify new genes for Alzheimer disease., PMID:37101235
Gene Expression Profiling as a Novel Diagnostic Tool for Neurodegenerative Disorders., PMID:36982820
For research use only. Not for human or drug use.
