Catalog No.
YHD85901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser44-Gln563
Predicted molecular weight
59.32 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P30038
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ALDH4, ALDH4A1, L-glutamate gamma-semialdehyde dehydrogenase, Aldehyde dehydrogenase family 4 member A1, P5CDH, P5C dehydrogenase, Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
ALDH4A1 functions as an active component of the MPC complex maintaining mitochondrial pyruvate import for TCA cycle entry and tumour suppression., PMID:40355545
ALDH Enzymes and Hematological Diseases: A Scoping Review of Literature., PMID:39726306
Physiological and transcriptomic analysis provides new insights into osmoregulation mechanism of Ruditapes philippinarum under low and high salinity stress., PMID:38750748
How Do Molecular Tweezers Bind to Proteins? Lessons from X-ray Crystallography., PMID:38675584
Atherosclerotic Autoantigen ALDH4A1 as a Novel Immunological Indicator for Plaque Erosion in Patients with ST Segment Elevated Myocardial Infarction., PMID:38109905
Sequences, phylogeny and evolution of mitochondrial delta-1-pyrroline-5-carboxylate dehydrogenases (ALDH4A1). Evidence for a second locus (ALDH4A2) in Drosophila., PMID:37597643
On pathways and blind alleys-The importance of biomarkers in vitamin B6 -dependent epilepsies., PMID:37428623
Identification of genes related to sexual differentiation and sterility in embryonic gonads of Mule ducks by transcriptome analysis., PMID:36386800
Genetic variation in ALDH4A1 is associated with muscle health over the lifespan and across species., PMID:35470798
Interleukin 21 Receptor Affects Adipogenesis of Human Adipose-Derived Stem/Stromal Cells., PMID:35047041
Dual Knockdown of Musashi RNA-Binding Proteins MSI-1 and MSI-2 Attenuates Putative Cancer Stem Cell Characteristics and Therapy Resistance in Ovarian Cancer Cells., PMID:34768932
Network Pharmacology-Based Analysis on the Potential Biological Mechanisms of Sinisan Against Non-Alcoholic Fatty Liver Disease., PMID:34512330
Structural basis for the stereospecific inhibition of the dual proline/hydroxyproline catabolic enzyme ALDH4A1 by trans-4-hydroxy-L-proline., PMID:34048122
Metabolic epilepsy in hyperprolinemia type II due to a novel nonsense ALDH4A1 gene variant., PMID:34037900
Structural analysis of prolines and hydroxyprolines binding to the l-glutamate-γ-semialdehyde dehydrogenase active site of bifunctional proline utilization A., PMID:33333077
ALDH4A1 is an atherosclerosis auto-antigen targeted by protective antibodies., PMID:33268892
ALDH4A1 expression levels are elevated in postmortem brains of patients with schizophrenia and are associated with genetic variants in enzymes related to proline metabolism., PMID:32065947
Identification of ALDH6A1 as a Potential Molecular Signature in Hepatocellular Carcinoma via Quantitative Profiling of the Mitochondrial Proteome., PMID:31985234
Novel variants in a patient with late-onset hyperprolinemia type II: diagnostic key for status epilepticus and lactic acidosis., PMID:31884946
Reduction of Fmr1 mRNA Levels Rescues Pathological Features in Cortical Neurons in a Model of FXTAS., PMID:31671347
Identification of the Biomarkers and Pathological Process of Osteoarthritis: Weighted Gene Co-expression Network Analysis., PMID:30941059
Polyploidy among salmonid aldehyde dehydrogenase genes and proteins., PMID:30776359
Integrative Analyses of Genes Associated with Subcutaneous Insulin Resistance., PMID:30678306
Alcohol Metabolism in the Progression of Human Nonalcoholic Steatohepatitis., PMID:29718361
Structural Biology of Proline Catabolic Enzymes., PMID:28990412
Confirmation of mutations in PROSC as a novel cause of vitamin B 6 -dependent epilepsy., PMID:28391250
Integrated Left Ventricular Global Transcriptome and Proteome Profiling in Human End-Stage Dilated Cardiomyopathy., PMID:27711126
SAXS fingerprints of aldehyde dehydrogenase oligomers., PMID:26693506
Structural Basis of Substrate Recognition by Aldehyde Dehydrogenase 7A1., PMID:26260980
Discovery of a series of aromatic lactones as ALDH1/2-directed inhibitors., PMID:25641190
Target discovery of acivicin in cancer cells elucidates its mechanism of growth inhibition†Electronic supplementary information (ESI) available: Synthesis, cloning, protein expression, purification and biochemical assays. See DOI: 10.1039/c4sc02339k., PMID:25580214
N,N-diethylaminobenzaldehyde (DEAB) as a substrate and mechanism-based inhibitor for human ALDH isoenzymes., PMID:25512087
SKN-1 and Nrf2 couples proline catabolism with lipid metabolism during nutrient deprivation., PMID:25284427
Structural studies of yeast Δ(1)-pyrroline-5-carboxylate dehydrogenase (ALDH4A1): active site flexibility and oligomeric state., PMID:24502590
Proteomic investigation of cultivated fibroblasts from patients with mitochondrial short-chain acyl-CoA dehydrogenase deficiency., PMID:24485985
Effect of zinc oxide nanomaterials-induced oxidative stress on the p53 pathway., PMID:24090840
Structural basis of substrate selectivity of Δ(1)-pyrroline-5-carboxylate dehydrogenase (ALDH4A1): semialdehyde chain length., PMID:23928095
A novel ALDH5A1 mutation is associated with succinic semialdehyde dehydrogenase deficiency and severe intellectual disability in an Iranian family., PMID:23825041
The three-dimensional structural basis of type II hyperprolinemia., PMID:22516612
Inborn errors of proline metabolism., PMID:18806117
Type II hyperprolinemia: a case report., PMID:15214748
Identification of ALDH4 as a p53-inducible gene and its protective role in cellular stresses., PMID:14986171
Polymorphisms of human aldehyde dehydrogenases. Consequences for drug metabolism and disease., PMID:10971205
Molecular enzymology of mammalian Delta1-pyrroline-5-carboxylate synthase. Alternative splice donor utilization generates isoforms with different sensitivity to ornithine inhibition., PMID:10037775
Mutations in the Delta1-pyrroline 5-carboxylate dehydrogenase gene cause type II hyperprolinemia., PMID:9700195
[A new inherited metabolic disease: delta1-pyrroline 5-carboxylate synthetase deficiency]., PMID:9622938
[Hyperprolinemia type II]., PMID:9590014
Assignment of the human gene encoding the delta 1-pyrroline-5-carboxylate synthetase (P5CS) to 10q24.3 by in situ hybridization., PMID:8921385
Cloning, characterization, and expression of cDNAs encoding human delta 1-pyrroline-5-carboxylate dehydrogenase., PMID:8621661
Database cloning human delta 1-pyrroline-5-carboxylate synthetase (P5CS) cDNA: a bifunctional enzyme catalyzing the first 2 steps in proline biosynthesis., PMID:8761662
For research use only. Not for human or drug use.
