Catalog No.
YHK65001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser178-Arg270
Predicted molecular weight
22.65 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9C004
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Protein sprouty homolog 4, Spry-4, SPRY4
Dual Regulation of Sprouty 4 Palmitoylation by ZDHHC7 and Palmitoyl-Protein Thioesterase 1: A Potential Therapeutic Strategy for Cisplatin-Resistant Osteosarcoma., PMID:40416361
[Clinicopathological features of primary thoracic synovial sarcoma: a study of 42 cases]., PMID:40302578
Oligogenic analysis across broad phenotypes of 46,XY differences in sex development associated with NR5A1/SF-1 variants: findings from the international SF1next study., PMID:40037090
A heterozygous SPRY4 variant identified in female infertility characterized by reduced oocyte potential and early embryonic arrest., PMID:39348320
SPRY4 regulates ERK1/2 phosphorylation to affect oxidative stress and steroidogenesis in polycystic ovary syndrome., PMID:39313103
ASCL1 Restrains ERK1/2 to Promote Survival of a Subset of Neuroendocrine Lung Cancers., PMID:39295275
Multiple endocrine defects in adult-onset Sprouty1/2/4 triple knockout mice., PMID:39174793
Gata6 functions in zebrafish endoderm to regulate late differentiating arterial pole cardiogenesis., PMID:39133135
Knockdown of miR-1293 attenuates lung adenocarcinoma angiogenesis via Spry4 upregulation-mediated ERK1/2 signaling inhibition., PMID:38972427
Role of SPRY4 in health and disease., PMID:38686189
Sprouty genes regulate activated fibroblasts in mammary epithelial development and breast cancer., PMID:38600092
Primary osteoarthritis chondrocyte map of chromatin conformation reveals novel candidate effector genes., PMID:38479789
Gene Expression Analyses in Models of Rosiglitazone-Induced Physiological and Pathological Mineralization Identify Novel Targets to Improve Bone and Vascular Health., PMID:37887306
LncRNA SPRY4-IT1 regulates 16HBE cell malignant transformation induced by particulate matter through DUSP6-ERK1/2-Chk1 signaling pathway., PMID:37797900
SPRY4-dependent ERK negative feedback demarcates functional adult stem cells in the male mouse germline†., PMID:37552049
SPRY4 inhibits and sensitizes the primary KIT mutants in gastrointestinal stromal tumors (GISTs) to imatinib., PMID:37222910
PDK1-stabilized LncRNA SPRY4-IT1 promotes breast cancer progression via activating NF-κB signaling pathway., PMID:37042573
Sprouty 4 expression in human oral squamous cell carcinogenesis., PMID:37021228
Long noncoding RNA SPRY4-IT1 acts as a miR-101-5p sponge to promote gastrointestinal stromal tumor progression by inhibiting ZEB1., PMID:36915750
LncRNA SPRY4‑IT1 is upregulated and promotes the proliferation of prostate cancer cells under hypoxia in vitro., PMID:36909367
Characterization of a Distinct State in the Continuum of Pluripotency Facilitated by Inhibition of PKCζ in Mouse Embryonic Stem Cells., PMID:36781773
LncRNA SPRY4-IT1 facilitates cell proliferation and angiogenesis of glioma via the miR-101-3p/EZH2/VEGFA signaling axis., PMID:36479622
Sprouty4 is epigenetically upregulated in human colorectal cancer., PMID:36384366
Optimized Transcriptional Signature for Evaluation of MEK/ERK Pathway Baseline Activity and Long-Term Modulations in Ovarian Cancer., PMID:36362153
Macrophage Sprouty4 deficiency diminishes sepsis-induced acute lung injury in mice., PMID:36334381
The long non-coding RNA SPRIGHTLY and its binding partner PTBP1 regulate exon 5 skipping of SMYD3 transcripts in group 4 medulloblastomas., PMID:36267874
Transcriptome Changes in Glioma Cells Cultivated under Conditions of Neurosphere Formation., PMID:36231068
SPRY4 promotes adipogenic differentiation of human mesenchymal stem cells through the MEK-ERK1/2 signaling pathway., PMID:36082406
A Novel Prognostic Risk Model for Cervical Cancer Based on Immune Checkpoint HLA-G-Driven Differentially Expressed Genes., PMID:35924232
Long non-coding RNA SPRY4-IT1 promotes proliferation and metastasis in nasopharyngeal carcinoma cell., PMID:35378932
FOXO1 represses sprouty 2 and sprouty 4 expression to promote arterial specification and vascular remodeling in the mouse yolk sac., PMID:35297995
[Retracted] MicroRNA‑181 serves an oncogenic role in breast cancer via the inhibition of SPRY4., PMID:35266013
Spatiotemporal Expression Patterns of Critical Genes Involved in FGF Signaling During Morphogenesis and Odontogenesis of Deciduous Molars in Miniature Pigs., PMID:34975307
Regulation of positive and negative selection and TCR signaling during thymic T cell development by capicua., PMID:34895467
The Role of lncRNAs in Regulating the Intestinal Mucosal Mechanical Barrier., PMID:34820453
The Development of Dentin Microstructure Is Controlled by the Type of Adjacent Epithelium., PMID:34783080
SPRY4 acts as an indicator of osteoarthritis severity and regulates chondrocyte hypertrophy and ECM protease expression., PMID:34535669
Loss of Sprouty Produces a Ciliopathic Skeletal Phenotype in Mice Through Upregulation of Hedgehog Signaling., PMID:34423857
Coupling HDAC4 with transcriptional factor MEF2D abrogates SPRY4-mediated suppression of ERK activation and elicits hepatocellular carcinoma drug resistance., PMID:34339801
A Review on the Expression Pattern of Non-coding RNAs in Patients With Schizophrenia: With a Special Focus on Peripheral Blood as a Source of Expression Analysis., PMID:34220567
NF-κB-activated SPRY4-IT1 promotes cancer cell metastasis by downregulating TCEB1 mRNA via Staufen1-mediated mRNA decay., PMID:34163032
Gene Instability-Related lncRNA Prognostic Model of Melanoma Patients via Machine Learning Strategy., PMID:34122546
Identification and biological analysis of LncSPRY4-IT1-targeted functional proteins in photoaging skin., PMID:34081809
Sprouty4 negatively regulates ERK/MAPK signaling and the transition from in situ to invasive breast ductal carcinoma., PMID:34048471
Identification of SPRY4 as a Novel Candidate Susceptibility Gene for Familial Nonmedullary Thyroid Cancer., PMID:33906393
SPRY4 suppresses proliferation and induces apoptosis of colorectal cancer cells by repressing oncogene EZH2., PMID:33879635
Long Noncoding RNA SPRY4-IT1 Modulates Ketamine-Induced Neurotoxicity in Human Embryonic Stem Cell-Derived Neurons through EZH2., PMID:33827085
Long non-coding RNA SPRY4-IT1 as a promising indicator for three field lymph-node dissection of thoracic esophageal carcinoma., PMID:33757566
A Sprouty4 Mutation Identified in Kallmann Syndrome Increases the Inhibitory Potency of the Protein towards FGF and Connected Processes., PMID:33670044
For research use only. Not for human or drug use.
