Catalog No.
YHK64701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser91-Ala372
Predicted molecular weight
33.29 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8N3J5
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PP2C-type mitochondrial phosphoprotein phosphatase, PP2C-like mitochondrial protein, Protein phosphatase 1K, mitochondrial, PP2CM, PP2C-kappa, PPM1K, PTMP, Protein phosphatase 2C isoform kappa, PP2C domain-containing protein phosphatase 1K
Genome-Wide Study of Diabetes Mellitus (Type 2)-Associated Genes in Homo sapiens (Human)., PMID:40462586
Transcutaneous auricular vaguas nerve stimulation promotes adipose tissue browning and mitochondrial integrity by regulating BCAA metabolism in obese rats: an experimental study., PMID:40387692
G protein-coupled oestrogen receptor regulates branched-chain amino acid metabolism through c-Jun N-terminal kinase., PMID:40047196
Expanding the Genetic Spectrum of PPM1K-Related Maple Syrup Urine Disease: A Novel Mutation., PMID:40047138
Multi-omic profiling of sarcopenia identifies disrupted branched-chain amino acid catabolism as a causal mechanism and therapeutic target., PMID:39910243
Phosphatase activity-based PPM1K: a key player in the regulation of mitochondrial function and its multifaceted impact in diseases., PMID:39695034
Multi-omics insights into the pathogenesis of diabetic cardiomyopathy: epigenetic and metabolic profiles., PMID:39623870
Partial correlation network analysis identifies coordinated gene expression within a regional cluster of COPD genome-wide association signals., PMID:39418301
miR-743b-3p promotes hepatic lipogenesis via branched-chain amino acids (BCAA) metabolism by targeting PPM1K in aged mice., PMID:38565071
Reduced Branched-Chain Amino Acid Intake Improved High-Fat Diet-Induced Nonalcoholic Fatty Pancreas Disease in Mice., PMID:38227616
PPM1K mediates metabolic disorder of branched-chain amino acid and regulates cerebral ischemia-reperfusion injury by activating ferroptosis in neurons., PMID:37752100
The amino acid metabolomics signature of differentiating myocardial infarction from strangulation death in mice models., PMID:37696922
Branched-chain keto acids inhibit mitochondrial pyruvate carrier and suppress gluconeogenesis in hepatocytes., PMID:37310861
PPM1K-regulated impaired catabolism of branched-chain amino acids orchestrates polycystic ovary syndrome., PMID:36863088
Fecal microbiome transplantation and tributyrin improves early cardiac dysfunction and modifies the BCAA metabolic pathway in a diet induced pre-HFpEF mouse model., PMID:36844730
Mitochondrial pyruvate carrier inhibition initiates metabolic crosstalk to stimulate branched chain amino acid catabolism., PMID:36801448
PPM1K defects cause mild maple syrup urine disease: The second case in the literature., PMID:36706222
Comprehensive Analysis of PPMs in Pancreatic Adenocarcinoma Indicates the Value of PPM1K in the Tumor Microenvironment., PMID:36672423
Branched-chain amino acid catabolism breaks glutamine addiction to sustain hepatocellular carcinoma progression., PMID:36417878
The expression of apoptosis related genes in HK-2 cells overexpressing PPM1K was determined by RNA-seq analysis., PMID:36386814
Identification and validation of a 9-gene signature for the prognosis of ovarian cancer by integrated bioinformatical analysis., PMID:36330389
Screening of biomarkers associated with diagnosis and prognosis of colorectal cancer., PMID:36104170
The role of branched chain amino acids metabolic disorders in tumorigenesis and progression., PMID:36076478
Association of Genetically Predicted BCAA Levels with Muscle Fiber Size in Athletes Consuming Protein., PMID:35327951
Effects of PPM1K rs1440581 and rs7678928 on serum branched-chain amino acid levels and risk of cardiovascular disease., PMID:34382495
Insulin action, type 2 diabetes, and branched-chain amino acids: A two-way street., PMID:34044180
Variants in urate transporters, ADH1B, GCKR and MEPE genes associate with transition from asymptomatic hyperuricaemia to gout: results of the first gout versus asymptomatic hyperuricaemia GWAS in Caucasians using data from the UK Biobank., PMID:33832965
Prevention properties on cerebral ischemia reperfusion of medicine food homologous Dioscorea yam-derived diosgenin based on mediation of potential targets., PMID:33352403
Metal-dependent Ser/Thr protein phosphatase PPM family: Evolution, structures, diseases and inhibitors., PMID:32650009
Subcellular proteomics combined with bioenergetic phenotyping reveals protein biomarkers of respiratory insufficiency in the setting of proofreading-deficient mitochondrial polymerase., PMID:32107436
Effects of Epigallocatechin Gallate (EGCG) on Urinary Bladder Urothelial Carcinoma-Next-Generation Sequencing and Bioinformatics Approaches., PMID:31805718
The study of copy number variations in the regions of PRKAB2 and PPM1K among congenital heart defects patients., PMID:31340305
Crystal structure and catalytic activity of the PPM1K N94K mutant., PMID:30451284
Association of branched chain amino acids related variant rs1440581 with risk of incident diabetes and longitudinal changes in insulin resistance in Chinese., PMID:29855804
The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase., PMID:29779826
PPM1K Regulates Hematopoiesis and Leukemogenesis through CDC20-Mediated Ubiquitination of MEIS1 and p21., PMID:29719258
BRANCHED CHAIN AMINO ACIDS AT THE EDGE BETWEEN MENDELIAN AND COMPLEX DISORDERS., PMID:31149264
Diabetes and branched-chain amino acids: What is the link?, PMID:29369529
Branched-chain amino acids and Alzheimer's disease: a Mendelian randomization analysis., PMID:29051501
Effect of the interaction between diet composition and the PPM1K genetic variant on insulin resistance and β cell function markers during weight loss: results from the Nutrient Gene Interactions in Human Obesity: implications for dietary guidelines (NUGENOB) randomized trial., PMID:28768654
The Relationship between Branched-Chain Amino Acid Related Metabolomic Signature and Insulin Resistance: A Systematic Review., PMID:27642608
Phosphorylated TandeMBP: A unique protein substrate for protein phosphatase assay., PMID:27565380
Regulation of PP2Cm expression by miRNA-204/211 and miRNA-22 in mouse and human cells., PMID:26592513
Branched-chain amino acids in metabolic signalling and insulin resistance., PMID:25287287
Genetic determinant for amino acid metabolites and changes in body weight and insulin resistance in response to weight-loss diets: the Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) trial., PMID:23446828
Transcribed pseudogene ψPPM1K generates endogenous siRNA to suppress oncogenic cell growth in hepatocellular carcinoma., PMID:23376929
A novel regulatory defect in the branched-chain α-keto acid dehydrogenase complex due to a mutation in the PPM1K gene causes a mild variant phenotype of maple syrup urine disease., PMID:23086801
A systems genetics approach identifies genes and pathways for type 2 diabetes in human islets., PMID:22768844
Incidence of apoptosis and transcript abundance in bovine follicular cells is associated with the quality of the enclosed oocyte., PMID:22578626
Structural and biochemical characterization of human mitochondrial branched-chain α-ketoacid dehydrogenase phosphatase., PMID:22291014
For research use only. Not for human or drug use.
