Catalog No.
YHB18801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Gly160
Predicted molecular weight
20.39 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O75396
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ERS-24, SEC22B, SEC22 vesicle-trafficking protein-like 1, SEC22L1, SEC22 vesicle-trafficking protein homolog B, ERS24, ER-Golgi SNARE of 24 kDa, Vesicle-trafficking protein SEC22b
TRIM16 mediates secretory autophagy in head and neck cancer-associated fibroblasts., PMID:40383937
Unconventional secretion of PARK7 requires lysosomal delivery via chaperone-mediated autophagy and specialized SNARE complex., PMID:40327696
Sphingosine kinase 2 deficiency impairs VLDL secretion by inhibiting mTORC2 phosphorylation and activating chaperone-mediated autophagy., PMID:40200091
Inhibitory Effect of Luteolin on Spike S1 Glycoprotein-Induced Inflammation in THP-1 Cells via the ER Stress-Inducing Calcium/CHOP/MAPK Pathway., PMID:39459041
Phosphoproteomics-directed manipulation reveals SEC22B as a hepatocellular signaling node governing metabolic actions of glucagon., PMID:39333498
SKArred 2 death: neuroinflammatory breakdown of the hippocampus., PMID:38934263
Legionella effectors SidC/SdcA ubiquitinate multiple small GTPases and SNARE proteins to promote phagosomal maturation., PMID:38836877
Development of Genetically Encoded Fluorescent KSR1-Based Probes to Track Ceramides during Phagocytosis., PMID:38474242
Human In vitro Modeling Identifies Adjuvant Combinations that Unlock Antigen Cross-presentation and Promote T-helper 1 Development in Newborns, Adults and Elders., PMID:38242283
Recruitment of PI4KIIIβ to the Golgi by ACBD3 is dependent on an upstream pathway of a SNARE complex and golgins., PMID:38134218
Qa-SNARE syntaxin 18 mediates lipid droplet fusion with SNAP23 and SEC22B., PMID:37989733
Ferritin Is Secreted from Primary Cultured Astrocyte in Response to Iron Treatment via TRPML1-Mediated Exocytosis., PMID:37947597
Ubiquitination of Sec22b by a novel Legionella pneumophila ubiquitin E3 ligase., PMID:37882795
A noncanonical function of SKP1 regulates the switch between autophagy and unconventional secretion., PMID:37831778
Sec22b regulates phagosome maturation by promoting ORP8-mediated lipid exchange at endoplasmic reticulum-phagosome contact sites., PMID:37794132
Sec22b and Stx4 Depletion Has No Major Effect on Cross-Presentation of PLGA Microsphere-Encapsulated Antigen and a Synthetic Long Peptide In Vitro., PMID:37638825
Secretory autophagy-promoted cargo exocytosis requires active RAB37., PMID:37151129
SEC22B inhibition attenuates colorectal cancer aggressiveness and autophagic flux under unfavorable environment., PMID:37148741
Alzheimer's disease-associated mutant ubiquitin (UBB+1) is secreted through an autophagosome-like vesicle-mediated unconventional pathway., PMID:37075976
Sec22b-dependent antigen cross-presentation is a significant contributor of T cell priming during infection with the parasite Trypanosoma cruzi., PMID:36936692
Mutations in Neurobeachin-like 2 do not impact Weibel-Palade body biogenesis and von Willebrand factor secretion in gray platelet syndrome Endothelial Colony Forming Cells., PMID:36923710
It takes a sec(22b) to accrue plasma cells., PMID:36789450
Sec22b is a critical and nonredundant regulator of plasma cell maintenance., PMID:36595686
Secretory autophagy: a turn key for understanding AMD pathology and developing new therapeutic targets?, PMID:36529978
Secretory autophagy promotes Rab37-mediated exocytosis of tissue inhibitor of metalloproteinase 1., PMID:36457117
Synthetic antibody-derived immunopeptide provides neuroprotection in glaucoma through molecular interaction with retinal protein histone H3.1., PMID:36313990
Extended-synaptotagmin 1 engages in unconventional protein secretion mediated via SEC22B+ vesicle pathway in liver cancer., PMID:36044553
A secretory form of Parkin-independent mitophagy contributes to the repertoire of extracellular vesicles released into the tumour interstitial fluid in vivo., PMID:35879267
Unbalanced Regulation of Sec22b and Ykt6 Blocks Autophagosome Axonal Retrograde Flux in Neuronal Ischemia-Reperfusion Injury., PMID:35654605
Autophagy in age-related macular degeneration., PMID:35468037
Dispatch and delivery at the ER-Golgi interface: how endothelial cells tune their hemostatic response., PMID:35246944
Syntaxin 5 determines Weibel-Palade body size and von Willebrand factor secretion by controlling Golgi architecture., PMID:35081689
Extracellular HSP90α Induces MyD88-IRAK Complex-Associated IKKα/β-NF-κB/IRF3 and JAK2/TYK2-STAT-3 Signaling in Macrophages for Tumor-Promoting M2-Polarization., PMID:35053345
BET1 variants establish impaired vesicular transport as a cause for muscular dystrophy with epilepsy., PMID:34779586
Sec22b Regulates Inflammatory Responses by Controlling the Nuclear Translocation of NF-κB and the Secretion of Inflammatory Mediators., PMID:34580108
Whole-Genome Profiles of Malay Colorectal Cancer Patients with Intact MMR Proteins., PMID:34573430
TAP dysfunction in dendritic cells enables noncanonical cross-presentation for T cell priming., PMID:33790474
Activity of the SNARE Protein SNAP29 at the Endoplasmic Reticulum and Golgi Apparatus., PMID:33718375
Resequencing and SNP discovery of Amur ide (Leuciscus waleckii) provides insights into local adaptations to extreme environments., PMID:33658614
Upregulation of Sec22b plays a neuroprotective role in a rat model of traumatic brain injury via inducing protective autophagy., PMID:33186631
COPII mitigates ER stress by promoting formation of ER whorls., PMID:32989223
Legionella Manipulates Non-canonical SNARE Pairing Using a Bacterial Deubiquitinase., PMID:32905772
Role of the Sec22b-E-Syt complex in neurite growth and ramification., PMID:32843578
The function of SEC22B and its role in human diseases., PMID:32748571
The endoplasmic reticulum protein SEC22B interacts with NBEAL2 and is required for megakaryocyte α-granule biogenesis., PMID:32384141
Sec22b determines Weibel-Palade body length by controlling anterograde ER-Golgi transport., PMID:32336681
Proteomic Analysis of Salmonella-modified Membranes Reveals Adaptations to Macrophage Hosts., PMID:32102972
The GTPase Rab39a promotes phagosome maturation into MHC-I antigen-presenting compartments., PMID:31821587
In Utero Dexamethasone Exposure Exacerbates Hepatic Steatosis in Rats That Consume Fructose During Adulthood., PMID:31491968
Divergent clonal evolution of a common precursor to mantle cell lymphoma and classic Hodgkin lymphoma., PMID:31395597
For research use only. Not for human or drug use.
