Catalog No.
YHK64601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala12-Asn152
Predicted molecular weight
18.39 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8WVM8
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
KIAA0917, Sly1p, C14orf163, STXBP1L2, Sec1 family domain-containing protein 1, SCFD1, Syntaxin-binding protein 1-like 2, SLY1 homolog
Proteome signature for differential diagnosis of patients with bilateral lung infiltrates., PMID:39963163
Visualization of ER-to-Golgi trafficking of procollagen X., PMID:39245571
Artificial neural network inference analysis identified novel genes and gene interactions associated with skeletal muscle aging., PMID:39210538
Identification of potential drug targets for amyotrophic lateral sclerosis by Mendelian randomization analysis based on brain and plasma proteomics., PMID:39116956
Anaplasma phagocytophilum effector EgeA facilitates infection by hijacking TANGO1 and SCFD1 from ER-Golgi exit sites to pathogen-occupied inclusions., PMID:39106308
Recruitment of PI4KIIIβ to the Golgi by ACBD3 is dependent on an upstream pathway of a SNARE complex and golgins., PMID:38134218
Identifying risk loci for FTD and shared genetic component with ALS: A large-scale multitrait association analysis., PMID:37979250
Loss of Sec-1 Family Domain-Containing 1 (scfd1) Causes Severe Cardiac Defects and Endoplasmic Reticulum Stress in Zebrafish., PMID:37887855
Abnormal Brain Protein Abundance and Cross-tissue mRNA Expression in Amyotrophic Lateral Sclerosis., PMID:37639066
Identifying novel genes for amyotrophic lateral sclerosis by integrating human brain proteomes with genome-wide association data., PMID:37148340
In Silico Exploration of Metabolically Active Peptides as Potential Therapeutic Agents against Amyotrophic Lateral Sclerosis., PMID:36982902
Loss of amyotrophic lateral sclerosis risk factor SCFD1 causes motor dysfunction in Drosophila., PMID:36944290
Prioritization of Drug Targets for Neurodegenerative Diseases by Integrating Genetic and Proteomic Data From Brain and Blood., PMID:36759259
An imaging-based RNA interference screen for modulators of the Rab6-mediated Golgi-to-ER pathway in mammalian cells., PMID:36523508
Acetylation of SCFD1 regulates SNARE complex formation and autophagosome-lysosome fusion., PMID:35465820
In PD-1+ human colon cancer cells NIVOLUMAB promotes survival and could protect tumor cells from conventional therapies., PMID:35246475
Lack of an association between SCFD1 rs10139154 polymorphism and amyotrophic lateral sclerosis., PMID:35234271
MTOR-mediates hepatic lipid metabolism through an autophagic SNARE complex., PMID:35174767
mTOR-mediated phosphorylation of VAMP8 and SCFD1 regulates autophagosome maturation., PMID:34785650
Genome-wide Meta-analysis Identifies Novel Genes Associated with Recurrence and Progression in Non-muscle-invasive Bladder Cancer., PMID:34353775
Shared genetic links between amyotrophic lateral sclerosis and obesity-related traits: a genome-wide association study., PMID:33640203
Genetic analysis of ALS cases in the isolated island population of Malta., PMID:33414559
Genome-wide Meta-analysis Finds the ACSL5-ZDHHC6 Locus Is Associated with ALS and Links Weight Loss to the Disease Genetics., PMID:33113361
Visualization of Procollagen IV Reveals ER-to-Golgi Transport by ERGIC-independent Carriers., PMID:32554938
Stx5-Mediated ER-Golgi Transport in Mammals and Yeast., PMID:31357511
Does SCFD1 rs10139154 Polymorphism Decrease Alzheimer's Disease Risk?, PMID:31267315
An association study between SCFD1 rs10139154 variant and amyotrophic lateral sclerosis in a Chinese cohort., PMID:29260601
The Sec domain protein Scfd1 facilitates trafficking of ECM components during chondrogenesis., PMID:27851892
Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis., PMID:27455348
SLY1 and Syntaxin 18 specify a distinct pathway for procollagen VII export from the endoplasmic reticulum., PMID:24842878
Autophagic substrate clearance requires activity of the syntaxin-5 SNARE complex., PMID:21242315
Direct interaction between the COG complex and the SM protein, Sly1, is required for Golgi SNARE pairing., PMID:19536132
Helicobacter pylori and antrum erosion-specific gene expression patterns: the discriminative role of CXCL13 and VCAM1 transcripts., PMID:18321301
Mutations of the SM protein Sly1 resulting in bypass of GTPase requirement in vesicular transport are confined to a short helical region., PMID:18036347
Three-dimensional structure of the rSly1 N-terminal domain reveals a conformational change induced by binding to syntaxin 5., PMID:15670607
RA410/Sly1 suppresses MPP+ and 6-hydroxydopamine-induced cell death in SH-SY5Y cells., PMID:15649705
rsly1 binding to syntaxin 5 is required for endoplasmic reticulum-to-Golgi transport but does not promote SNARE motif accessibility., PMID:14565970
Molecular cloning and characterization of a novel SH3 protein (SLY) preferentially expressed in lymphoid cells., PMID:11470164
Syntaxin 17 is abundant in steroidogenic cells and implicated in smooth endoplasmic reticulum membrane dynamics., PMID:10930465
Cloning of a putative vesicle transport-related protein, RA410, from cultured rat astrocytes and its expression in ischemic rat brain., PMID:9195952
Mammalian Sly1 regulates syntaxin 5 function in endoplasmic reticulum to Golgi transport., PMID:8663406
For research use only. Not for human or drug use.
