Catalog No.
YHK64501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
His111-Thr388
Predicted molecular weight
34.44 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9ULU4
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Protein kinase C-binding protein 1, PRKCBP1, RACK7, ZMYND8, CTCL-associated antigen se14-3, Cutaneous T-cell lymphoma-associated antigen se14-3, Rack7, KIAA1125, Zinc finger MYND domain-containing protein 8
HBO1 functions as an epigenetic barrier to hepatocyte plasticity and reprogramming during liver injury., PMID:40403721
ZMYND8 Reads H3K36me2 to Activate CEBPE Transcription and Suppress Multiple Myeloma Progression through the Inhibition of Adaptive UPR Pathways., PMID:40347515
ZMYND8 drives HER2 antibody resistance in breast cancer via lipid control of IL-27., PMID:40281007
The RBM39 degrader indisulam inhibits acute megakaryoblastic leukemia by altering the alternative splicing of ZMYND8., PMID:40223119
RACK7 Interacts with PRC2 Complex to Regulate Astrocyte Development., PMID:40125808
Targeting the histone reader ZMYND8 inhibits antiandrogen-induced neuroendocrine tumor transdifferentiation of prostate cancer., PMID:40102673
ABL Kinases Modulate EZH2 Phosphorylation and Signaling in Metastatic Triple Negative Breast Cancer., PMID:40027835
Catalytic-independent functions of the Integrator-PP2A complex (INTAC) confer sensitivity to BET inhibition., PMID:39809894
Gender-different effect of Src family kinases antagonism on photophobia and trigeminal ganglion activity., PMID:39390364
USP7 deubiquitinates epigenetic reader ZMYND8 to promote breast cancer cell migration and invasion., PMID:39128723
The Molecular and Biological Function of MEF2D in Leukemia., PMID:39017853
Basis of gene-specific transcription regulation by the Integrator complex., PMID:38906142
Cell surface CD55 traffics to the nucleus leading to cisplatin resistance and stemness by inducing PRC2 and H3K27 trimethylation on chromatin in ovarian cancer., PMID:38853277
ZMYND8 Is a Regulator of Sonic Hedgehog Signaling in ATRA-Mediated Differentiation of Neuroblastoma Cells., PMID:38804064
ZMYND8 protects breast cancer stem cells against oxidative stress and ferroptosis through activation of NRF2., PMID:38488001
Radiosensitization of IDH-Mutated Gliomas through ZMYND8 - a Pathway to Improved Outcomes., PMID:36826993
Zinc Finger MYND-Type Containing 8 (ZMYND8) Is Epigenetically Regulated in Mutant Isocitrate Dehydrogenase 1 (IDH1) Glioma to Promote Radioresistance., PMID:36692427
The BRD4 Inhibitor dBET57 Exerts Anticancer Effects by Targeting Superenhancer-Related Genes in Neuroblastoma., PMID:36438198
CHD4 plays a critical role in arsenite-induced oxidative damage in human urothelial carcinoma., PMID:36306724
Pseudotime analysis reveals novel regulatory factors for multigenic onset and monogenic transition of odorant receptor expression., PMID:36171231
ARID1A-dependent maintenance of H3.3 is required for repressive CHD4-ZMYND8 chromatin interactions at super-enhancers., PMID:36153585
ZMYND8 suppresses MAPT213 LncRNA transcription to promote neuronal differentiation., PMID:36064715
De Novo ZMYND8 variants result in an autosomal dominant neurodevelopmental disorder with cardiac malformations., PMID:35916866
Combinatorial targeting of Hippo-STRIPAK and PARP elicits synthetic lethality in gastrointestinal cancers., PMID:35290241
ZMYND8 mediated liquid condensates spatiotemporally decommission the latent super-enhancers during macrophage polarization., PMID:34764296
Aberrant FBXW7-mediated ubiquitination and degradation of ZMYND8 enhances tumor progression and stemness in bladder cancer., PMID:34487730
Exploiting a key transcriptional dependency: ZMYND8 and IRF8 in AML., PMID:34478652
Validation of ZMYND8 as a new treatment target in hepatocellular carcinoma., PMID:34462784
ZMYND8-regulated IRF8 transcription axis is an acute myeloid leukemia dependency., PMID:34358447
The Dual Function of KDM5C in Both Gene Transcriptional Activation and Repression Promotes Breast Cancer Cell Growth and Tumorigenesis., PMID:33977073
The ZMYND8-regulated mevalonate pathway endows YAP-high intestinal cancer with metabolic vulnerability., PMID:33932349
Regulation of ZMYND8 to Treat Cancer., PMID:33670804
ZMYND8 preferentially binds phosphorylated EZH2 to promote a PRC2-dependent to -independent function switch in hypoxia-inducible factor-activated cancer., PMID:33593912
ZMYND8 promotes the growth and metastasis of hepatocellular carcinoma by promoting HK2-mediated glycolysis., PMID:33517164
Suppression of poised oncogenes by ZMYND8 promotes chemo-sensitization., PMID:33323928
ZMYND8 Expression in Breast Cancer Cells Blocks T-Lymphocyte Surveillance to Promote Tumor Growth., PMID:33148660
RACK7 recognizes H3.3G34R mutation to suppress expression of MHC class II complex components and their delivery pathway in pediatric glioblastoma., PMID:32832624
Emerging Multi-cancer Regulatory Role of ESRP1: Orchestration of Alternative Splicing to Control EMT., PMID:32564755
A recurrent PJA1 variant in trigonocephaly and neurodevelopmental disorders., PMID:32530565
Relationship among DNA double-strand break (DSB), DSB repair, and transcription prevents genome instability and cancer., PMID:32232911
ZMYND8 expression combined with pN and pM classification as a novel prognostic prediction model for colorectal cancer: Based on TCGA and GEO database analysis., PMID:32224527
A novel role of tumor suppressor ZMYND8 in inducing differentiation of breast cancer cells through its dual-histone binding function., PMID:31965980
Mapping Bromodomains in breast cancer and association with clinical outcome., PMID:30952871
The endogenous retrovirus-derived long noncoding RNA TROJAN promotes triple-negative breast cancer progression via ZMYND8 degradation., PMID:30854423
Protein kinase C binding protein 1 inhibits hypoxia-inducible factor-1 in the heart., PMID:30395227
The Chromatin Reader ZMYND8 Regulates Igh Enhancers to Promote Immunoglobulin Class Switch Recombination., PMID:30293785
"Z4" Complex Member Fusions in NUT Carcinoma: Implications for a Novel Oncogenic Mechanism., PMID:30139738
Positive Regulation of Transcription by Human ZMYND8 through Its Association with P-TEFb Complex., PMID:30134174
ZMYND8 acetylation mediates HIF-dependent breast cancer progression and metastasis., PMID:29629903
Double duty: ZMYND8 in the DNA damage response and cancer., PMID:29393731
For research use only. Not for human or drug use.
