Catalog No.
YHH88701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu23-Thr143
Predicted molecular weight
16.40 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q53GL0
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PH domain-containing family O member 1, CK2-interacting protein 1, Osteoclast maturation-associated gene 120 protein, OC120, JBP, Casein kinase 2-interacting protein 1, C-Jun-binding protein, CKIP1, PLEKHO1, CKIP-1, Pleckstrin homology domain-containing family O member 1
MicroRNA-6069 ASO inhibits the growth of hepatocellular carcinoma by PLEKHO1., PMID:39956470
The Transcription Factor ATF2 Accelerates Clear Cell Renal Cell Carcinoma Progression Through Activating the PLEKHO1/NUS1 Pathway., PMID:39777695
The Discovery of a Specific CKIP-1 Ligand for the Potential Treatment of Disuse Osteoporosis., PMID:39201556
CKIP-1 silencing suppresses OSCC via mitochondrial homeostasis-associated TFAM/cGAS-STING signalling axis., PMID:39169452
Ckip-1 3'UTR alleviates prolonged sleep deprivation induced cardiac dysfunction by activating CaMKK2/AMPK/cTNI pathway., PMID:38871861
Construction of molecular subgroups of ulcerative colitis., PMID:37843347
Spatiotemporal resolution of germinal center Tfh cell differentiation and divergence from central memory CD4+ T cell fate., PMID:37330549
[Effect of CKIP-1 on hepatocyte apoptosis in nonalcoholic fatty liver disease]., PMID:36631036
The Prognostic Signature of Head and Neck Squamous Cell Carcinoma Constructed by Immune-Related RNA-Binding Proteins., PMID:35449571
The effect of QiangGuYin on osteoporosis through the AKT/mTOR/autophagy signaling pathway mediated by CKIP-1., PMID:35073518
Akt scaffold proteins: the key to controlling specificity of Akt signaling., PMID:34161152
Analyzing and validating the prognostic value and mechanism of colon cancer immune microenvironment., PMID:32859214
High expression of the CKIP-1 gene might promote apoptosis through downregulation of the Ras/ERK signalling pathway in the intestinal type of gastric cancer., PMID:32223671
Casein kinase 2 interacting protein 1 positively regulates caudal-related homeobox 1 in intestinal-type gastric cancer., PMID:31868807
Prostatic epithelial cells and their high expressions of CKIP-1 affect the TGF-β1 expression levels which might reduce the scar formation in remodeling stage at prostatic urethral wounds after wound repair., PMID:31542883
Casein Kinase 2 Interacting Protein-1 Suppresses Glioma Cell Proliferation via Regulating the AKT/GSK3β/β-Catenin Pathway., PMID:31355268
Statins as the Controlling Agents for Non-Hodgkin's Lymphomas via Increasing the Casein Kinase 2 Interacting Protein-1: A Hypothesis., PMID:31264550
PLEKHO1 knockdown inhibits RCC cell viability in vitro and in vivo, potentially by the Hippo and MAPK/JNK pathways., PMID:31180521
Physiological functions of CKIP-1: From molecular mechanisms to therapy implications., PMID:31082489
Osteoblastic PLEKHO1 contributes to joint inflammation in rheumatoid arthritis., PMID:30824383
Extra-gastrointestinal stromal tumours displaying pure epithelioid cytomorphology are a diagnostic challenge on cytology smears., PMID:30556219
CKIP-1 suppresses odontoblastic differentiation of dental pulp stem cells via BMP2 pathway and can interact with NRP1., PMID:29852799
Novel non-ATP competitive small molecules targeting the CK2 α/β interface., PMID:29759799
Heterodimeric capping protein is required for stereocilia length and width regulation., PMID:28899994
PLEKHO2 is essential for M-CSF-dependent macrophage survival., PMID:28627369
A novel role of CKIP-1 in promoting megakaryocytic differentiation., PMID:28404913
Association of CKIP-1 P21A polymorphism with risk of chronic heart failure in a Chinese population., PMID:28402261
Casein Kinase 2 Interacting Protein-1 regulates M1 and M2 inflammatory macrophage polarization., PMID:28212865
Increased PLEKHO1 within osteoblasts suppresses Smad-dependent BMP signaling to inhibit bone formation during aging., PMID:28083909
Silencing of CKIP-1 promotes tumor proliferation and cell adhesion-mediated drug resistance via regulating AKT activity in non-Hodgkin's lymphoma., PMID:27840970
Different Array CGH profiles within hereditary breast cancer tumors associated to BRCA1 expression and overall survival., PMID:26979459
The Role of the Pleckstrin Homology Domain-containing Protein CKIP-1 in Activation of p21-activated Kinase 1 (PAK1)., PMID:26160174
Chitosan/siCkip-1 biofunctionalized titanium implant for improved osseointegration in the osteoporotic condition., PMID:26040545
Role of the CKIP1 gene in proliferation and apoptosis of the human lung cancer cell line H1299., PMID:25966172
Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference-based bone anabolic strategy., PMID:25665179
Whole-genome analysis of temporal gene expression during early transdifferentiation of human lung alveolar epithelial type 2 cells in vitro., PMID:24690998
CKIP-1 is an intrinsic negative regulator of T-cell activation through an interaction with CARMA1., PMID:24465689
Therapeutic RNA interference targeting CKIP-1 with a cross-species sequence to stimulate bone formation., PMID:24246247
CKIP-1 acts as a colonic tumor suppressor by repressing oncogenic Smurf1 synthesis and promoting Smurf1 autodegradation., PMID:23995790
Casein kinase 2-interacting protein-1, an inflammatory signaling molecule interferes with TNF reverse signaling in human model cells., PMID:23583459
Crystallization and preliminary X-ray crystallographic analysis of the human CKIP-1 pleckstrin homology domain., PMID:23519814
CKIP-1 couples Smurf1 ubiquitin ligase with Rpt6 subunit of proteasome to promote substrate degradation., PMID:23032291
CKIP-1: a scaffold protein and potential therapeutic target integrating multiple signaling pathways and physiological functions., PMID:22878216
CKIP-1 regulates mammalian and zebrafish myoblast fusion., PMID:22553210
A delivery system targeting bone formation surfaces to facilitate RNAi-based anabolic therapy., PMID:22286306
N-terminal PH domain and C-terminal auto-inhibitory region of CKIP-1 coordinate to determine its nucleus-plasma membrane shuttling., PMID:20171213
Casein kinase 2-interacting protein-1, a novel Akt pleckstrin homology domain-interacting protein, down-regulates PI3K/Akt signaling and suppresses tumor growth in vivo., PMID:17942896
The PH domain containing protein CKIP-1 binds to IFP35 and Nmi and is involved in cytokine signaling., PMID:17197158
The role of CKIP-1 in cell morphology depends on its interaction with actin-capping protein., PMID:16987810
Identification of a novel inhibitory actin-capping protein binding motif in CD2-associated protein., PMID:16707503
For research use only. Not for human or drug use.
