Catalog No.
YHD14901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Gln231
Predicted molecular weight
28.08 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P16083
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
QR2, NMOR2, NQO2, Quinone reductase 2, NRH:quinone oxidoreductase 2, NRH dehydrogenase [quinone] 2, Ribosyldihydronicotinamide dehydrogenase [quinone]
Sulforaphane treatment of HL-60 cells protects against clozapine toxicity and protein covalent binding: implications for clozapine-induced agranulocytosis., PMID:40436238
The induction of quinone oxidoreductases NQO1 and NQO2 by clozapine: Potential implications for clozapine-induced agranulocytosis., PMID:40311769
Discovery of potent quinone oxidoreductase 2 inhibitors to overcome TRAIL resistance of non-small cell lung cancer., PMID:39987833
FRK exerts oncogenic effects by targeting NQO2 via exosomal miR-9-3p to regulate mitochondrial function., PMID:39625368
Evolutionary analysis of Quinone Reductases 1 and 2 suggests that NQO2 evolved to function as a pseudoenzyme., PMID:39584664
In vitro modelling of Parkinson's disease using 6-OHDA is associated with increased NQO2 activity., PMID:39271030
Melatonin Receptor Expression in Primary Uveal Melanoma., PMID:39201396
Beneficial effects of melatonin on boar sperm motility and kinematics are mediated by MT1 receptor., PMID:38870584
Proteomic and Phosphoproteomic Analysis of Right Ventricular Hypertrophy in the Pulmonary Hypertension Rat Model., PMID:38015796
Afzelin induces immunogenic cell death against lung cancer by targeting NQO2., PMID:37891619
The combination of multi-approach studies to explore the potential therapeutic mechanisms of imidazole derivatives as an MCF-7 inhibitor in therapeutic strategies., PMID:37441272
Expression of the melatonergic system during meiotic maturation of cynomolgus monkey cumulus-oocyte complexes., PMID:36973936
Mechanism of action and promising clinical application of melatonin from a dermatological perspective., PMID:36860771
Differential haplotype expression in class I MHC genes during SARS-CoV-2 infection of human lung cell lines., PMID:36818472
The influence of NQO2 on the dysfunctional autophagy and oxidative stress induced in the hippocampus of rats and in SH-SY5Y cells by fluoride., PMID:36650666
Measuring the NQO2: Melatonin Complex by Native Nano-Electrospray Ionization Mass Spectrometry., PMID:36180703
Melatonin Binding to Human NQO2 by Isothermal Titration Calorimetry., PMID:36180701
Cloning, Expression, Purification, Crystallization, and X-Ray Structural Determination of the Human NQO2 in Complex with Melatonin., PMID:36180700
Measuring Binding at the Putative Melatonin Receptor MT3., PMID:36180699
An Axis between the Long Non-Coding RNA HOXA11-AS and NQOs Enhances Metastatic Ability in Oral Squamous Cell Carcinoma., PMID:36142607
Quantitative Proteomics Explore the Potential Targets and Action Mechanisms of Hydroxychloroquine., PMID:36014414
Multiplex protein profiling of bronchial aspirates reveals disease-, mortality- and respiratory sequelae-associated signatures in critically ill patients with ARDS secondary to SARS-CoV-2 infection., PMID:35967328
Preparation and Cytotoxic Evaluation of PGV-1 Derivative, CCA-1.1, as a New Curcumin Analog with Improved-Physicochemical and Pharmacological Properties., PMID:35935043
Proteomic analysis of iTRAQ in melatonin-treated sheep epididymal epithelial cells., PMID:35881670
Nephrotoxicity evaluation and proteomic analysis in kidneys of rats exposed to thioacetamide., PMID:35477741
SAR of Novel 3-Arylisoquinolinones: meta-Substitution on the Aryl Ring Dramatically Enhances Antiproliferative Activity through Binding to Microtubules., PMID:35290041
Identification of NQO2 As a Protein Target in Small Molecule Modulation of Hepatocellular Function., PMID:34427427
Interactions of the antioxidant enzymes NAD(P)H: Quinone oxidoreductase 1 (NQO1) and NRH: Quinone oxidoreductase 2 (NQO2) with pharmacological agents, endogenous biochemicals and environmental contaminants., PMID:34228969
Involvement of Chaperone Sigma1R in the Anxiolytic Effect of Fabomotizole., PMID:34064275
Journal of pineal research guideline for authors: Defining and characterizing melatonin targets., PMID:33332653
Curcumol Overcomes TRAIL Resistance of Non-Small Cell Lung Cancer by Targeting NRH:Quinone Oxidoreductase 2 (NQO2)., PMID:33240775
Dopamine-Dependent QR2 Pathway Activation in CA1 Interneurons Enhances Novel Memory Formation., PMID:33046554
Molecular Pharmacology of NRH:Quinone Oxidoreductase 2: A Detoxifying Enzyme Acting as an Undercover Toxifying Enzyme., PMID:32913139
Muscarinic-Dependent miR-182 and QR2 Expression Regulation in the Anterior Insula Enables Novel Taste Learning., PMID:32217627
Tuning melatonin receptor subtype selectivity in oxadiazolone-based analogues: Discovery of QR2 ligands and NRF2 activators with neurogenic properties., PMID:32018096
GSK3β is a key regulator of the ROS-dependent necrotic death induced by the quinone DMNQ., PMID:31919413
Effect of Fabomotizole on Brain Gene Expression in MR Rats in the Open Field Test., PMID:31768849
Anti-proliferative and Anti-metastatic Potential of Curcumin Analogue, Pentagamavunon-1 (PGV-1), Toward Highly Metastatic Breast Cancer Cells in Correlation with ROS Generation., PMID:31592109
Cancer-associated variants of human NQO1: impacts on inhibitor binding and cooperativity., PMID:31431515
Keap1/Nrf2 Signaling: A New Player in Thyroid Pathophysiology and Thyroid Cancer., PMID:31428048
Role of Nrf2-antioxidant in radioprotection by root extract of Inula racemosa., PMID:30998083
Is There Sufficient Evidence that the Melatonin Binding Site MT3 Is Quinone Reductase 2?, PMID:30389722
NRH:quinone oxidoreductase 2 (NQO2) and glutaminase (GLS) both play a role in large extracellular vesicles (LEV) formation in preclinical LNCaP-C4-2B prostate cancer model of progressive metastasis., PMID:30009389
Expressions of some antioxidant genes in SH-SY5Y cells treated with β-lapachone, morphine and electromagnetic field., PMID:29611025
Inter-individual Variability in Activity of the Major Drug Metabolizing Enzymes in Liver Homogenates of 20 Individuals., PMID:29318967
Reduction and Scavenging of Chemically Reactive Drug Metabolites by NAD(P)H:Quinone Oxidoreductase 1 and NRH:Quinone Oxidoreductase 2 and Variability in Hepatic Concentrations., PMID:29281794
NQO2 inhibition relieves reactive oxygen species effects on mouse oocyte meiotic maturation and embryo development., PMID:29025057
Application of open-access databases to determine functional connectivity between resveratrol-binding protein QR2 and colorectal carcinoma., PMID:28646291
The ontogeny and population variability of human hepatic dihydronicotinamide riboside:quinone oxidoreductase (NQO2)., PMID:28346733
Delamanid is not metabolized by Salmonella or human nitroreductases: A possible mechanism for the lack of mutagenicity., PMID:27988333
For research use only. Not for human or drug use.
