Catalog No.
YHG92101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala211-Ser261
Predicted molecular weight
18.13 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q14916
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
NPT1, Renal sodium-phosphate transport protein 1, Renal sodium-dependent phosphate transport protein 1, Sodium-dependent phosphate transport protein 1, Renal Na(+)-dependent phosphate cotransporter 1, Sodium/phosphate cotransporter 1, Na(+)/PI cotransporter 1, Solute carrier family 17 member 1, Na/Pi-4, SLC17A1
Association of rare and common genetic variants in MOCOS with inadequate response to allopurinol., PMID:39137147
Examining the Association of Rare Allelic Variants in Urate Transporters SLC22A11, SLC22A13, and SLC17A1 with Hyperuricemia and Gout., PMID:38222853
A genome-wide association study of 24-hour urinary excretion of endocrine disrupting chemicals., PMID:38150807
Linkage analysis using whole exome sequencing data implicates SLC17A1, SLC17A3, TATDN2 and TMEM131L in type 1 diabetes in Kuwaiti families., PMID:37696853
GLUT9 as a potential drug target for chronic kidney disease: Drug target validation by a Mendelian randomization study., PMID:37308567
The impact of genetic variability in urate transporters on oxypurinol pharmacokinetics., PMID:36398357
E4BP4 Regulates Hepatic Solute Carrier Family 2 Member 9 and Uric Acid Disposition in Mice., PMID:35246462
The Time-Feature of Uric Acid Excretion in Hyperuricemia Mice Induced by Potassium Oxonate and Adenine., PMID:32707836
Deciphering genetic signatures by whole exome sequencing in a case of co-prevalence of severe renal hypouricemia and diabetes with impaired insulin secretion., PMID:32375679
Genetic Analyses in Dent Disease and Characterization of CLCN5 Mutations in Kidney Biopsies., PMID:31947599
Associations between single nucleotide polymorphisms and erythrocyte parameters in humans: A systematic literature review., PMID:31097152
Multiple Membrane Transporters and Some Immune Regulatory Genes are Major Genetic Factors to Gout., PMID:30123371
Probable Potential Role of Urate Transporter Genes in the Development of Metabolic Disorders., PMID:29850377
The systems biology of uric acid transporters: the role of remote sensing and signaling., PMID:29847376
Expression of Phosphate Transporters during Dental Mineralization., PMID:28892649
Mendelian randomization analysis indicates serum urate has a causal effect on renal function in Chinese women., PMID:28856502
Expression of a human NPT1/SLC17A1 missense variant which increases urate export., PMID:27906618
GWAS of clinically defined gout and subtypes identifies multiple susceptibility loci that include urate transporter genes., PMID:27899376
Stimulation of V1a receptor increases renal uric acid clearance via urate transporters: insight into pathogenesis of hypouricemia in SIADH., PMID:26935049
[Polymorphisms of SLC17A1 gene and their interaction with alcohol drinking among Uygur patients with hyperuricemia]., PMID:26663070
Genetic variants of SLC17A1 are associated with cholesterol homeostasis and hyperhomocysteinaemia in Japanese men., PMID:26524967
Polymorphisms in GCKR, SLC17A1 and SLC22A12 were associated with phenotype gout in Han Chinese males: a case-control study., PMID:26290326
SLC2A9 Genotype Is Associated with SLC2A9 Gene Expression and Urinary Uric Acid Concentration., PMID:26167684
Mendelian randomization analysis to examine for a causal effect of urate on bone mineral density., PMID:25502344
Serum uric acid levels are associated with polymorphisms in the SLC2A9, SF1, and GCKR genes in a Chinese population., PMID:25283508
NPT1/SLC17A1 is a renal urate exporter in humans and its common gain-of-function variant decreases the risk of renal underexcretion gout., PMID:25252215
Tubular urate transporter gene polymorphisms differentiate patients with gout who have normal and decreased urinary uric acid excretion., PMID:25128519
The rate of production of uric acid by hepatocytes is a sensitive index of compromised cell ATP homeostasis., PMID:24045866
Type 1 sodium-dependent phosphate transporter acts as a membrane potential-driven urate exporter., PMID:23876149
Population-specific effects of SLC17A1 genotype on serum urate concentrations and renal excretion of uric acid during a fructose load., PMID:23852697
A genome wide association study of plasma uric acid levels in obese cases and never-overweight controls., PMID:23703922
SLC17: a functionally diverse family of organic anion transporters., PMID:23506876
[The roles of intestinal and renal sodium dependent phosphate transporters in phosphate homeostasis]., PMID:23023625
Pathway analysis of genome-wide association studies on uric acid concentrations., PMID:22609445
The renal urate transporter SLC17A1 locus: confirmation of association with gout., PMID:22541845
A Na+-phosphate cotransporter homologue (SLC17A4 protein) is an intestinal organic anion exporter., PMID:22460716
Roles of major facilitator superfamily transporters in phosphate response in Drosophila., PMID:22359624
Recent advances in renal urate transport: characterization of candidate transporters indicated by genome-wide association studies., PMID:22038265
Population heterogeneity in the genetic control of serum urate., PMID:22000648
Sodium-dependent phosphate cotransporters: lessons from gene knockout and mutation studies., PMID:21567407
A genome-wide association study of red blood cell traits using the electronic medical record., PMID:20927387
A 'complexity' of urate transporters., PMID:20613716
Type 1 sodium-dependent phosphate transporter (SLC17A1 Protein) is a Cl(-)-dependent urate exporter., PMID:20566650
Glutamate, aspartate and nucleotide transporters in the SLC17 family form four main phylogenetic clusters: evolution and tissue expression., PMID:20059771
Common polymorphisms influencing serum uric acid levels contribute to susceptibility to gout, but not to coronary artery disease., PMID:19890391
Sodium-dependent phosphate cotransporter type 1 sequence polymorphisms in male patients with gout., PMID:19556210
Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations., PMID:19503597
New insights into renal transport of urate., PMID:17278930
PDZK1: I. a major scaffolder in brush borders of proximal tubular cells., PMID:14531806
Identification of a novel voltage-driven organic anion transporter present at apical membrane of renal proximal tubule., PMID:12740363
For research use only. Not for human or drug use.
