Catalog No.
YHK63901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr36-Leu173
Predicted molecular weight
17.72 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q969H8
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
MYDGF, C19orf10, Myeloid-derived growth factor
Serum Levels of IL-21 and IL-27 Do not Reflect differential Avidity of Anti-SARS-CoV-2 IgG Antibodies in Symptomatic and Asymptomatic COVID-19 Patients., PMID:40471646
Integrating Transcriptomic and Proteomic Data: IL-27B as a Key Protein in the Development of Septic Cardiomyopathy-A Retrospective Study., PMID:40396598
Development of a Long-Acting Myeloid-Derived Growth Factor via Site-Specific PEGylation., PMID:40289344
Intestinal IL-25 prevents high-fat diet-induced obesity by modulating the cholesterol transporter NPC1L1 expression in the intestinal epithelial cells., PMID:40140439
Interleukin-27-polarized HIV-resistant M2 macrophages are a novel subtype of macrophages that express distinct antiviral gene profiles in individual cells: implication for the antiviral effect via different mechanisms in the individual cell-dependent manner., PMID:40129989
Tuft cell IL-17RB restrains IL-25 bioavailability and reveals context-dependent ILC2 hypoproliferation., PMID:40074948
Impact of single nucleotide polymorphism of IL-27P28 rs153109 and IFITM3 rs12252 on susceptibility and severity of COVID-19 in Egyptian patients: a case control study., PMID:40057761
Transcytosis of LDL Across Arterial Endothelium: Mechanisms and Therapeutic Targets., PMID:40013359
Vesicles Secreted by Renal Cell Carcinoma Cells Cause Vascular Endothelial Cells to Express PSMA and Drive Tumor Progression., PMID:39936957
IL-27 elicits a cytotoxic CD8+ T cell program to enforce tumour control., PMID:39910298
Harnessing IL-27: challenges and potential in cancer immunotherapy., PMID:39797931
Interleukin-27 and Autoimmune Disorders: A Compressive Review of Immunological Functions., PMID:39766196
Accuracy of interleukin-27 in diagnosing tuberculous pleural effusion: Age should be considered., PMID:39742701
IL-27 as a novel biomarker for pruritus in nodular prurigo and bullous pemphigoid., PMID:39735535
Paraoxonase-1 Is a Pivotal Regulator Responsible for Suppressing Allergic Airway Inflammation Through Adipose Stem Cell-Derived Extracellular Vesicles., PMID:39684469
IL-41: A novel serum marker correlates with disease activity in patients with ankylosing spondylitis., PMID:39614798
Tubular MYDGF Slows Progression of Chronic Kidney Disease by Maintaining Mitochondrial Homeostasis., PMID:39587987
N-CADHERIN+/CD168- subpopulation determines therapeutic variations of UC-MSCs for cardiac repair after myocardial infarction., PMID:39533355
Blood flow-induced angiocrine signals promote organ growth and regeneration., PMID:39529434
Increased circulating levels of novel anti-inflammatory cytokines IL-27 and IL-38 are associated with immunoendrocrine dysregulation and altered redox stress in polycystic ovarian syndrome., PMID:39509823
Myeloid-derived growth factor promotes M2 macrophage polarization and attenuates Sjögren's syndrome via suppression of the CX3CL1/CX3CR1 axis., PMID:39497829
Peripheral biomarkers of Parkinson's disease and its correlation with clinical symptoms: a case-control study., PMID:39468494
IL-27 attenuated macrophage injury and inflammation induced by Mycobacterium tuberculosis by activating autophagy., PMID:39455490
Emerging Roles of IL-27 in Trophoblast Cells and Pregnancy Complications., PMID:39422056
[The role and its regulatory significance of interleukin-25 in ovalbumin induced atopic dermatitis of mice]., PMID:39397451
Trained immunity of intestinal tuft cells during infancy enhances host defense against enteroviral infections in mice., PMID:39261649
Causal relationship between Interleukin-27 expression levels and osteoporosis: a bidirectional mendelian randomization study., PMID:39210324
Immunoregulatory Cells and Cytokines Discriminate Disease Activity Score 28-Remission Statuses and Ultrasound Grades in Rheumatoid Arthritis Patients with Non-High Disease Activity., PMID:39201379
Proteomic Profile of Endometrial Cancer: A Scoping Review., PMID:39194522
[Loss of Myeloid-Derived Growth Factor Leads to Increased Fibrosis in Mice After Myocardial Infarction]., PMID:39170023
Impaired IL-27 signaling aggravates macrophage senescence and sensitizes premature ovarian insufficiency induction by high-fat diet., PMID:39153664
Soluble expression of hMYDGF was improved by strain engineering and optimizations of fermentation strategies in Escherichia coli., PMID:39111350
Role of IL-27 in COVID-19: A Thin Line between Protection and Disease Promotion., PMID:39063193
The Novel Cytokine Interleukin-41/Meteorin-like Is Reduced in Diffuse Systemic Sclerosis., PMID:39056787
Myeloid-derived growth factor in diseases: structure, function and mechanisms., PMID:39030488
IL-27 expression regulation and its effects on adaptive immunity against viruses., PMID:38966644
Interleukin 27, Similar to Interferons, Modulates Gene Expression of Tripartite Motif (TRIM) Family Members and Interferes with Mayaro Virus Replication in Human Macrophages., PMID:38932287
Circulating interleukin-27 is associated with the risk of chronic periodontitis and allergic rhinitis: A Mendelian randomization analysis., PMID:38829359
Interleukin-27 is positively correlated with obesity and a decrease in insulin resistance after weight loss., PMID:38796383
Glycyrrhizin attenuates renal inflammation in a mouse Con A-hepatitis model via the IL-25/M2 axis., PMID:38785317
IL27 and IL1RN are causally associated with acute pancreatitis: a Mendelian randomization study., PMID:38742942
Interleukin 27, like interferons, activates JAK-STAT signaling and promotes pro-inflammatory and antiviral states that interfere with dengue and chikungunya viruses replication in human macrophages., PMID:38720890
Myeloid-derived growth factor ameliorates dextran sodium sulfate-induced colitis by regulating macrophage polarization., PMID:38695882
The effects of IL-27 and IL-35 gene variation and expression levels on the susceptibility and clinical manifestations of pulmonary tuberculosis., PMID:38690286
Role of IL-27 in Epstein-Barr virus infection revealed by IL-27RA deficiency., PMID:38509369
Is myeloid-derived growth factor a ligand of the sphingosine-1-phosphate receptor 2?, PMID:38484568
Transcriptomic Analysis Reveals Sixteen Potential Genes Associated with the Successful Differentiation of Antibody-Secreting Cells through the Utilization of Unfolded Protein Response Mechanisms in Robust Responders to the Influenza Vaccine., PMID:38400120
IL-27 alters inflammatory cytokine expression and limits protective immunity against Mycobacterium tuberculosis in a neonatal BCG vaccination model., PMID:38390338
Identification of myeloid-derived growth factor as a mechanically-induced, growth-promoting angiocrine signal for human hepatocytes., PMID:38316785
Chemical Proteomics and Morphological Profiling Revealing MYDGF as a Target for Synthetic Anticancer Macromolecules., PMID:38225889
For research use only. Not for human or drug use.
