Catalog No.
YHK63801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser23-Arg216
Predicted molecular weight
24.92 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q7L9L4
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
MOBKL1A, MOB kinase activator 1B, MOB4A, MOB1B, Mob1 homolog 1A, Mob1B, Mob1A, Mps one binder kinase activator-like 1A
Decoding gene expression profiles of Hippo signaling pathway components in breast cancer., PMID:39928181
Exploring the effects of Hippo signaling pathway on rumen epithelial proliferation., PMID:38730465
The compensatory increase of Gli-similar 3 inhibited neuronal apoptosis through regulating Mps one binder kinase activator 1b (MOB1b): a possible strategy for the functional recovery after spinal cord injury., PMID:37574269
[Doublecortin-like kinase 1 activates Hippo pathway to promote migration, invasion and proliferation of pancreatic cancer cells]., PMID:37462016
Mob4 is essential for spermatogenesis in Drosophila melanogaster., PMID:37259670
KIAA1429-mediated m6A modification of CHST11 promotes progression of diffuse large B-cell lymphoma by regulating Hippo-YAP pathway., PMID:37076815
Genome-wide association study for milk production and conformation traits in Canadian Alpine and Saanen dairy goats., PMID:36526463
Perfluorooctanoic acid (PFOA) promotes follicular growth and alters expression of genes that regulate the cell cycle and the Hippo pathway in cultured neonatal mouse ovaries., PMID:36152675
Hippo-TAZ signaling is the master regulator of the onset of triple-negative basal-like breast cancers., PMID:35858357
MAP3Kε1/2 Interact with MOB1A/1B and Play Important Roles in Control of Pollen Germination through Crosstalk with JA Signaling in Arabidopsis., PMID:35269823
EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1., PMID:34725466
TAZ inhibits acinar cell differentiation but promotes immature ductal cell proliferation in adult mouse salivary glands., PMID:34142411
Cryo-EM structure of the Hippo signaling integrator human STRIPAK., PMID:33633399
The Arabidopsis AGC kinases NDR2/4/5 interact with MOB1A/1B and play important roles in pollen development and germination., PMID:33215783
PINK1-Dependent Mitophagy Regulates the Migration and Homing of Multiple Myeloma Cells via the MOB1B-Mediated Hippo-YAP/TAZ Pathway., PMID:32154065
Loss of Mob1a/b impairs the differentiation of mouse embryonic stem cells into the three germ layer lineages., PMID:31723125
MOB1 regulates thymocyte egress and T-cell survival in mice in a YAP1-independent manner., PMID:31125466
Depletion of MOB1A/B causes intestinal epithelial degeneration by suppressing Wnt activity and activating BMP/TGF-β signaling., PMID:30349003
miR-135b-5p regulates human mesenchymal stem cell osteogenic differentiation by facilitating the Hippo signaling pathway., PMID:31966624
MOB1 Mediated Phospho-recognition in the Core Mammalian Hippo Pathway., PMID:28373298
Regulation of Protein Interactions by Mps One Binder (MOB1) Phosphorylation., PMID:28373297
MOB1-YAP1/TAZ-NKX2.1 axis controls bronchioalveolar cell differentiation, adhesion and tumour formation., PMID:28346423
Structural basis for autoinhibition and its relief of MOB1 in the Hippo pathway., PMID:27335147
The Hippo pathway in intestinal regeneration and disease., PMID:27147489
The characterisation of LATS2 kinase regulation in Hippo-YAP signalling., PMID:26898830
Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice., PMID:26699479
The Hippo/STE20 homolog SIK1 interacts with MOB1 to regulate cell proliferation and cell expansion in Arabidopsis., PMID:26685188
Lats1 Deletion Causes Increased Germ Cell Apoptosis and Follicular Cysts in Mouse Ovaries., PMID:26040669
Genetic variants in Hippo pathway genes YAP1, TEAD1 and TEAD4 are associated with melanoma-specific survival., PMID:25628125
Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions., PMID:24255178
The Arabidopsis thaliana Mob1A gene is required for organ growth and correct tissue patterning of the root tip., PMID:24201137
Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice., PMID:23143302
Function and cancer genomics of FAT family genes (review)., PMID:23076869
Human Mob1 proteins are required for cytokinesis by controlling microtubule stability., PMID:22454515
The Mst1 and Mst2 kinases control activation of rho family GTPases and thymic egress of mature thymocytes., PMID:22412158
Protein phosphatase 2a (PP2A) binds within the oligomerization domain of striatin and regulates the phosphorylation and activation of the mammalian Ste20-Like kinase Mst3., PMID:21985334
MOB control: reviewing a conserved family of kinase regulators., PMID:21539912
Differential NDR/LATS interactions with the human MOB family reveal a negative role for human MOB2 in the regulation of human NDR kinases., PMID:20624913
Mutual dependence of Mob1 and the chromosomal passenger complex for localization during mitosis., PMID:19955215
Roles of mammalian sterile 20-like kinase 2-dependent phosphorylations of Mps one binder 1B in the activation of nuclear Dbf2-related kinases., PMID:19919647
The MST1 and hMOB1 tumor suppressors control human centrosome duplication by regulating NDR kinase phosphorylation., PMID:19836237
Molecular characterization of human homologs of yeast MOB1., PMID:19739119
Mammalian NDR/LATS protein kinases in hippo tumor suppressor signaling., PMID:19484742
The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells., PMID:19073936
MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation., PMID:18328708
Human MOB1 expression in non-small-cell lung cancer., PMID:17311693
The human tumour suppressor LATS1 is activated by human MOB1 at the membrane., PMID:16674920
Regulation of NDR protein kinase by hydrophobic motif phosphorylation mediated by the mammalian Ste20-like kinase MST3., PMID:16314523
Human NDR kinases are rapidly activated by MOB proteins through recruitment to the plasma membrane and phosphorylation., PMID:16135814
Human LATS1 is a mitotic exit network kinase., PMID:16061636
For research use only. Not for human or drug use.
