Catalog No.
YHK63701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser37-Ser257
Predicted molecular weight
27.83 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8IUF8
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ROX, MDIG, Nucleolar protein 52, Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA, Ribosomal oxygenase 2, MINA, Histone lysine demethylase MINA, Ribosomal oxygenase MINA, MYC-induced nuclear antigen, RIOX2, 60S ribosomal protein L27a histidine hydroxylase, Mineral dust-induced gene protein, NO52, MINA53
MicroRNA-140-3p inhibits proliferation and promotes apoptosis in non-small cell lung cancer by targeting MDIG., PMID:38009637
Jumonji domain-containing protein RIOX2 is overexpressed and associated with worse survival outcomes in prostate cancers., PMID:36776320
MDIG, a 2‑oxoglutarate‑dependent oxygenase, acts as an oncogene and predicts the prognosis of multiple types of cancer., PMID:35583005
Epigenomic reprogramming via HRP2-MINA dictates response to proteasome inhibitors in multiple myeloma with t(4;14) translocation., PMID:35166240
The unfavorable clinical outcome of COVID-19 in smokers is mediated by H3K4me3, H3K9me3 and H3K27me3 histone marks., PMID:35021853
The bioinformatics analysis of RIOX2 gene in lung adenocarcinoma and squamous cell carcinoma., PMID:34855761
First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53., PMID:34843649
Environmentally-induced mdig contributes to the severity of COVID-19 through fostering expression of SARS-CoV-2 receptor NRPs and glycan metabolism., PMID:34335974
Cooperation between NRF2-mediated transcription and MDIG-dependent epigenetic modifications in arsenic-induced carcinogenesis and cancer stem cells., PMID:33823236
The mineral dust-induced gene, mdig, regulates angiogenesis and lymphangiogenesis in lung adenocarcinoma by modulating the expression of VEGF-A/C/D via EGFR and HIF-1α signaling., PMID:33760153
Pathological and Prognostic Indications of the mdig Gene in Human Lung Cancer., PMID:33423409
CRISPR-Cas9 gene editing causes alternative splicing of the targeting mRNA., PMID:32460957
ZNF143-Mediated H3K9 Trimethylation Upregulates CDC6 by Activating MDIG in Hepatocellular Carcinoma., PMID:32312832
[Significance of expression of Myc-induced nuclear antigen 53 in hepatocellular carcinoma and its relationship with patient prognosis]., PMID:32306660
Mdig promotes oncogenic gene expression through antagonizing repressive histone methylation markers., PMID:31903140
New discoveries of mdig in the epigenetic regulation of cancers., PMID:31276784
A CRISPR/Cas9 screen identifies the histone demethylase MINA53 as a novel HIV-1 latency-promoting gene (LPG)., PMID:31165872
The small members of the JMJD protein family: Enzymatic jewels or jinxes?, PMID:31034925
Mina53 regulates the differentiation and proliferation of leukemia cells., PMID:30991463
MINA53 deficiency leads to glioblastoma cell apoptosis via inducing DNA replication stress and diminishing DNA damage response., PMID:30333481
Phylogenetic and genomic analyses of the ribosomal oxygenases Riox1 (No66) and Riox2 (Mina53) provide new insights into their evolution., PMID:29914368
Mina53 nuclear localization is an important indicator of prognosis in patients with colorectal cancer after adjuvant chemotherapy., PMID:29750310
SETDB2 and RIOX2 are differentially expressed among renal cell tumor subtypes, associating with prognosis and metastization., PMID:29099276
Mdig suppresses epithelial-mesenchymal transition and inhibits the invasion and metastasis of non‑small cell lung cancer via regulating GSK-3β/β-catenin signaling., PMID:29039479
A SNP uncoupling Mina expression from the TGFβ signaling pathway., PMID:28967702
Dysfunction of IKZF1/MYC/MDIG axis contributes to liver cancer progression through regulating H3K9me3/p21 activity., PMID:28471446
Analysis of adverse events following immunization in Minas Gerais, Brazil, 2011: a cross-sectional study., PMID:27861677
Proteomic Characterization of the World Trade Center dust-activated mdig and c-myc signaling circuit linked to multiple myeloma., PMID:27833099
MINA controls proliferation and tumorigenesis of glioblastoma by epigenetically regulating cyclins and CDKs via H3K9me3 demethylation., PMID:27292258
MYC-induced nuclear antigen (MINA) and preeclampsia., PMID:26910584
Histone Modifier Genes Alter Conotruncal Heart Phenotypes in 22q11.2 Deletion Syndrome., PMID:26608785
The proteomic investigation reveals interaction of mdig protein with the machinery of DNA double-strand break repair., PMID:26293673
Mdig, a lung cancer-associated gene, regulates cell cycle progression through p27(KIP1)., PMID:25851349
Studies on the catalytic domains of multiple JmjC oxygenases using peptide substrates., PMID:25625844
Mina: a Th2 response regulator meets TGFβ., PMID:25282476
Potential effects of Mina53 on tumor growth in human pancreatic cancer., PMID:24522517
Paradoxical roles of mineral dust induced gene on cell proliferation and migration/invasion., PMID:24505346
Carcinogenic metalloid arsenic induces expression of mdig oncogene through JNK and STAT3 activation., PMID:24434654
Mina53, a novel molecular marker for the diagnosis and prognosis of gastric adenocarcinoma., PMID:24337011
Increased expression of mdig predicts poorer survival of the breast cancer patients., PMID:24309373
Mdig de-represses H19 large intergenic non-coding RNA (lincRNA) by down-regulating H3K9me3 and heterochromatin., PMID:23965803
Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans., PMID:23103944
Associations of the single-nucleotide polymorphisms of the Mina gene with the development of asthma in Chinese Han children: a case-control study., PMID:21631300
Expression of Mina53, a novel c-Myc target gene, is a favorable prognostic marker in early stage lung cancer., PMID:19914733
Mina53, a novel c-Myc target gene, is frequently expressed in lung cancers and exerts oncogenic property in NIH/3T3 cells., PMID:19756735
Lung cancer-associated JmjC domain protein mdig suppresses formation of tri-methyl lysine 9 of histone H3., PMID:19502796
Expression of Mina53 and its significance in gastric carcinoma., PMID:18629780
Immunohistochemical expressions of Cap43 and Mina53 proteins in neuroblastoma., PMID:18022432
Overexpression of the myc target gene Mina53 in advanced renal cell carcinoma., PMID:17803656
Expression of Myc target gene mina53 in subtypes of human lymphoma., PMID:17786344
For research use only. Not for human or drug use.
