Catalog No.
YHK63501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg42-Met373
Predicted molecular weight
38.36 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9BV79
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
MECR, NRBF-1, Nuclear receptor-binding factor 1, NBRF1, 2-enoyl thioester reductase, HsNrbf-1, Enoyl-[acyl-carrier-protein] reductase, mitochondrial
Identification of Downregulated MECR Gene in Parkinson's Disease Through Integrated Transcriptomic Analysis and Validation., PMID:39859268
Engineered bacterial lipoate protein ligase A (lplA) restores lipoylation in cell models of lipoylation deficiency., PMID:39547509
Unveiling the therapeutic potential of Canavalia rosea leaves: Exploring antioxidant, anti-inflammatory, anti-arthritic, and cytotoxic activities through biological and molecular docking evaluation with DFT analysis., PMID:39403519
A comparative study on the effects of fungal and bacterial phytase with or without citric acid on growth performance, serum mineral profile, bone quality, and nutrient retention in broilers., PMID:39101093
The 3-hydroxyacyl-CoA dehydratase 1/2 form complex with trans-2-enoyl-CoA reductase involved in substrates transfer in very long chain fatty acid elongation., PMID:38422897
Application of deep brain stimulation for the treatment of childhood-onset dystonia in patients with MEPAN syndrome., PMID:38328756
Recurrent MECR R258W causes adult-onset optic atrophy: A case report., PMID:38296034
Catalytic mechanism of trans-2-enoyl-CoA reductases in the fatty acid elongation cycle and its cooperative action with fatty acid elongases., PMID:38224948
The Identification of Functional Genes Affecting Fat-Related Meat Traits in Meat-Type Pigeons Using Double-Digest Restriction-Associated DNA Sequencing and Molecular Docking Analysis., PMID:37893980
Recessive MECR pathogenic variants cause an LHON-like optic neuropathy., PMID:37734847
Human skeletal muscle methylome after low-carbohydrate energy-balanced exercise., PMID:37018654
Transcriptome Profiling of the Liver in Nellore Cattle Phenotypically Divergent for RFI in Two Genetic Groups., PMID:36766249
An engineered variant of MECR reductase reveals indispensability of long-chain acyl-ACPs for mitochondrial respiration., PMID:36739436
Peroxisomal trans-2-enoyl-CoA inhibits proliferation, migration and invasion of hepatocellular carcinoma cells., PMID:36724637
Alternative splicing liberates a cryptic cytoplasmic isoform of mitochondrial MECR that antagonizes influenza virus., PMID:36542656
Ophthalmic manifestations of MEPAN syndrome., PMID:36262091
High Expression of ACOT2 Predicts Worse Overall Survival and Abnormal Lipid Metabolism: A Potential Target for Acute Myeloid Leukemia., PMID:36193167
Remodelin, a N-acetyltransferase 10 (NAT10) inhibitor, alters mitochondrial lipid metabolism in cancer cells., PMID:34605570
Identification and validation of hub genes for diabetic retinopathy., PMID:34603851
RNA-seq analysis reveals the positive role of KLF5 in the differentiation of subcutaneous adipocyte in goats., PMID:34530084
Diclofenac Resensitizes Methicillin-Resistant Staphylococcus aureus to β-Lactams and Prevents Implant Infections., PMID:34258168
Nucleic acid binding by SAMHD1 contributes to the antiretroviral activity and is enhanced by the GpsN modification., PMID:33531504
Trans-2-enoyl-CoA reductase limits Ca2+ accumulation in the endoplasmic reticulum by inhibiting the Ca2+ pump SERCA2b., PMID:33482198
Methanolic extract of Cariniana rubra Gardner ex Miers stem bark negatively regulate the leukocyte migration and TNF-α and up-regulate the annexin-A1 expression., PMID:33421601
Whole exome sequencing identifies a novel homozygous MECR mutation in a Chinese patient with childhood-onset dystonia and basal ganglia abnormalities, without optic atrophy., PMID:33401012
Quantitative Proteomic Profiling of Mitochondrial Toxicants in a Human Cardiomyocyte Cell Line., PMID:32733541
ATP reduces mitochondrial MECR protein in liver of diet-induced obese mice in mechanism of insulin resistance., PMID:32440681
Unveiling Pharmacological Responses and Potential Targets Insights of Identified Bioactive Constituents of Cuscuta reflexa Roxb. Leaves through In Vivo and In Silico Approaches., PMID:32245131
The effects of chronic cadmium exposure on Bufo gargarizans larvae: Histopathological impairment, gene expression alteration and fatty acid metabolism disorder in the liver., PMID:32199138
Lipoic acid alleviates schistosomiasis-induced liver fibrosis by upregulating Drp1 phosphorylation., PMID:32194067
Exploration of targets regulated by miR-125b in porcine adipocytes., PMID:31912457
Bta-miR-124a Affects Lipid Metabolism by Regulating PECR Gene., PMID:31467878
Knockdown expression of MECR, a novel gene of mitochondrial FAS II inhibits growth and colony-formation, promotes apoptosis of hepatocelluar carcinoma cells., PMID:31178528
Identification of rare-disease genes using blood transcriptome sequencing and large control cohorts., PMID:31160820
A major isoform of mitochondrial trans-2-enoyl-CoA reductase is dispensable for wax ester production in Euglena gracilis under anaerobic conditions., PMID:30650145
Impaired Mitochondrial Fatty Acid Synthesis Leads to Neurodegeneration in Mice., PMID:30266742
The effect of QTL-rich region polymorphisms identified by targeted DNA-seq on pig production traits., PMID:29623566
Plasmid-Encoded Transferable mecB-Mediated Methicillin Resistance in Staphylococcus aureus., PMID:29350135
Clinical isolates of Escherichia coli solely resistant to mecillinam: prevalence and epidemiology., PMID:29154843
Reversion of High-level Mecillinam Resistance to Susceptibility in Escherichia coli During Growth in Urine., PMID:28855073
Non-electron transfer chain mitochondrial defects differently regulate HIF-1α degradation and transcription., PMID:28531964
A conserved threonine prevents self-intoxication of enoyl-thioester reductases., PMID:28504678
Genetic modifications of Mecr reveal a role for mitochondrial 2-enoyl-CoA/ACP reductase in placental development in mice., PMID:28369354
Gastroprotective potential of methanolic extract and dimethyl cardamonin from Campomanesia reitziana fruits in mice., PMID:28365824
The Well-Known Gene HHIP and Novel Gene MECR Are Implicated in Small Airway Obstruction., PMID:27845578
MECR Mutations Cause Childhood-Onset Dystonia and Optic Atrophy, a Mitochondrial Fatty Acid Synthesis Disorder., PMID:27817865
Antidiabetic effects of Cuscuta reflexa Roxb. in streptozotocin induced diabetic rats., PMID:27649679
Altering the Mitochondrial Fatty Acid Synthesis (mtFASII) Pathway Modulates Cellular Metabolic States and Bioactive Lipid Profiles as Revealed by Metabolomic Profiling., PMID:26963735
For research use only. Not for human or drug use.
