Catalog No.
YHK63401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser90-Lys366
Predicted molecular weight
33.26 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UJA3
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
MCM8, C20orf154, Minichromosome maintenance 8, DNA helicase MCM8
The potential of MCM8 as a biomarker in esophageal carcinoma: a comprehensive analysis integrating m6a methylation and angiogenesis., PMID:40346692
AmNA-Modified Antisense Oligonucleotide Targeting MCM8 as a Cancer-Specific Chemosensitizer for Platinum Compounds., PMID:40098305
EP300 Modulates MCM8 Transcription and Augments the Malignant Phenotype of Hepatitis B Virus-Positive Hepatocellular Carcinoma Cells., PMID:40095759
A novel homozygous frameshift mutation in MCM8 causes primary gonadal dysgenesis in both genders., PMID:40064807
Expression patterns of MCM8 in lung adenocarcinoma and its correlation with key biological processes., PMID:40033404
MCM8 promotes NR4A1-mediated E2F1 transcription and facilitates renal cell carcinoma through enhancing aerobic glycolysis., PMID:39992472
HROB Is Implicated in DNA Replication., PMID:39766854
Transcriptional analysis reveals the suppression of RAD51 and disruption of the homologous recombination pathway during PEDV infection in IPEC-J2 cells., PMID:39731192
Investigation of an MCM8 gene variant in women with premature ovarian insufficiency., PMID:39607112
MCM8-mediated mitophagy protects vascular health in response to nitric oxide signaling in a mouse model of Kawasaki disease., PMID:39195969
Understanding the novel MCM8 gene mutation: primary ovarian insufficiency and uterine hypoplasia in siblings., PMID:39074937
MCM8 promotes lung cancer progression through upregulating DNAJC10., PMID:39031896
MCM8 promotes gastric cancer progression through RPS15A and predicts poor prognosis., PMID:38988047
MCM8 interacts with DDX5 to promote R-loop resolution., PMID:38858601
Mechanism of DNA unwinding by MCM8-9 in complex with HROB., PMID:38678026
A novel cancer-germline gene DAZL promotes progression and cisplatin resistance of non-small cell lung cancer by upregulating JAK2 and MCM8., PMID:38588931
Function and mechanism of MCM8 in the development and progression of colorectal cancer., PMID:37710286
Structural and mechanistic insights into the MCM8/9 helicase complex., PMID:37535404
TRMT6 gene rs236110 C > A polymorphism increases the risk of Wilms tumor., PMID:37473973
Mechanism of DNA unwinding by hexameric MCM8-9 in complex with HROB., PMID:37461676
Mechanism of DNA unwinding by hexameric MCM8-9 in complex with HROB., PMID:37398313
Molecular functions of MCM8 and MCM9 and their associated pathologies., PMID:37378315
Enhancer-driven transcription of MCM8 by E2F4 promotes ATR pathway activation and glioma stem cell characteristics., PMID:37349788
Activity, substrate preference and structure of the HsMCM8/9 helicase., PMID:37309874
High MCM8 expression correlates with unfavorable prognosis and induces immune cell infiltration in hepatocellular carcinoma., PMID:36575045
Identification and analysis of C17orf53 as a prognostic signature for hepatocellular carcinoma., PMID:36470143
MCM4 is a novel prognostic biomarker and promotes cancer cell growth in glioma., PMID:36465369
REC drives recombination to repair double-strand breaks in animal mtDNA., PMID:36355348
A multi-functional role for the MCM8/9 helicase complex in maintaining fork integrity during replication stress., PMID:36042199
Pan-Cancer Analysis Identified Homologous Recombination Factor With OB-Fold (HROB) as a Potential Biomarker for Various Tumor Types., PMID:35903352
Genome-wide association study meta-analysis identifies three novel loci for circulating anti-Müllerian hormone levels in women., PMID:35274129
Whole-exome sequencing improves the diagnosis and care of men with non-obstructive azoospermia., PMID:35172124
Associations of MCM8 rs3761873 and rs16991617 variants with abnormal uterine bleeding induced by copper intrauterine device., PMID:34889489
Genetics of ovarian insufficiency and defects of folliculogenesis., PMID:34794894
Meiotic genes in premature ovarian insufficiency: variants in HROB and REC8 as likely genetic causes., PMID:34707299
Downregulation of MCM8 expression restrains the malignant progression of cholangiocarcinoma., PMID:34523691
The Immunohistochemical Expression of MCM-3, -5, and -7 Proteins in the Uterine Fibroids., PMID:34449552
Bioinformatics analysis of the transcriptional expression of minichromosome maintenance proteins as potential indicators of survival in patients with cervical cancer., PMID:34404366
MCM8 is regulated by EGFR signaling and promotes the growth of glioma stem cells through its interaction with DNA-replication-initiating factors., PMID:34131285
Silencing HIPPI Suppresses Tumor Progression in Non-Small-Cell Lung Cancer by Inhibiting DNA Replication., PMID:34079292
Structural study of the N-terminal domain of human MCM8/9 complex., PMID:34043945
Knockdown of MCM8 inhibits development and progression of bladder cancer in vitro and in vivo., PMID:33931059
Knockdown of MCM8 functions as a strategy to inhibit the development and progression of osteosarcoma through regulating CTGF., PMID:33828075
Motifs of the C-terminal domain of MCM9 direct localization to sites of mitomycin-C damage for RAD51 recruitment., PMID:33539926
Meiosis interrupted: the genetics of female infertility via meiotic failure., PMID:33170803
Identification of mini-chromosome maintenance 8 as a potential prognostic marker and its effects on proliferation and apoptosis in gastric cancer., PMID:33155430
MCM10 Acts as a Potential Prognostic Biomarker and Promotes Cell Proliferation in Hepatocellular Carcinoma: Integrated Bioinformatics Analysis and Experimental Validation., PMID:33116820
C17orf53 is identified as a novel gene involved in inter-strand crosslink repair., PMID:32853826
Germline biallelic Mcm8 variants are associated with early-onset Lynch-like syndrome., PMID:32841224
Two novel mutations in the MCM8 gene shared by two Chinese siblings with primary ovarian insufficiency and short stature., PMID:32652893
For research use only. Not for human or drug use.
