Catalog No.
YHK63201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
His544-Ala718
Predicted molecular weight
21.76 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9Y6D9
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
HsMAD1, MAD1-like protein 1, hMAD1, Mitotic arrest deficient 1-like protein 1, Tax-binding protein 181, MAD1, TXBP181, Mitotic checkpoint MAD1 protein homolog, MAD1L1, Mitotic spindle assembly checkpoint protein MAD1
Loss of negative regulation by HDAC1 and REST contributes to MAD1 overexpression in breast cancer., PMID:40464797
Interplay of kinetochores and catalysts drives rapid assembly of the mitotic checkpoint complex., PMID:40410156
Causal associations between circulating protein ratios and drug resistance in papillary thyroid cancer: a Mendelian randomization study., PMID:39754686
Fatal Spitz Melanoma With MAD1L1::BRAF Fusion: A Case Report and Literature Review., PMID:39723589
Proteomic Analysis of Biomarkers Predicting Treatment Response in Patients with Head and Neck Cancers., PMID:39684225
Association Between Peptide Antigen-Related Antibody Levels and the Short- and Long-Term Efficacy of Antipsychotic Treatment in Drug-Naïve First-Episode Schizophrenia Patients., PMID:39673496
Germline DNA Damage Repair Gene Alterations in Patients with Metachronous Breast and Colorectal Cancer., PMID:39408606
MAD1 upregulation sensitizes to inflammation-mediated tumor formation., PMID:39374311
Exosomal transcript cargo and functional correlation with HNSCC patients' survival., PMID:39272022
DNA methylation near MAD1L1, KDM2B, and SOCS3 mediates the effect of socioeconomic status on elevated body mass index in African American adults., PMID:39079086
Dissecting the shared genetic architecture between Alzheimer's disease and frailty: a cross-trait meta-analyses of genome-wide association studies., PMID:38706793
Human genetic associations of the airway microbiome in chronic obstructive pulmonary disease., PMID:38622589
A common cis-regulatory variant impacts normal-range and disease-associated human facial shape through regulation of PKDCC during chondrogenesis., PMID:38483448
Transcriptomic correlates of cell cycle checkpoints with distinct prognosis, molecular characteristics, immunological regulation, and therapeutic response in colorectal adenocarcinoma., PMID:38143740
The HNF4A-CHPF pathway promotes proliferation and invasion through interactions with MAD1L1 in glioma., PMID:37851364
Integrative multi-omics analysis of genomic, epigenomic, and metabolomics data leads to new insights for Attention-Deficit/Hyperactivity Disorder., PMID:37534875
Genome-Wide Methylation Profiling in 229 Patients With Crohn's Disease Requiring Intestinal Resection: Epigenetic Analysis of the Trial of Prevention of Post-operative Crohn's Disease (TOPPIC)., PMID:37331566
Multi-CpG linear regression models to accurately predict paclitaxel and docetaxel activity in cancer cell lines., PMID:36990534
Whole-exome Sequencing of Nigerian Prostate Tumors from the Prostate Cancer Transatlantic Consortium (CaPTC) Reveals DNA Repair Genes Associated with African Ancestry., PMID:36922933
Methylation in MAD1L1 is associated with the severity of suicide attempt and phenotypes of depression., PMID:36600305
Schizophrenia-associated Mitotic Arrest Deficient-1 (MAD1) regulates the polarity of migrating neurons in the developing neocortex., PMID:36357673
Biallelic germline mutations in MAD1L1 induce a syndrome of aneuploidy with high tumor susceptibility., PMID:36322655
Schizophrenia-associated differential DNA methylation in brain is distributed across the genome and annotated to MAD1L1, a locus at which DNA methylation and transcription phenotypes share genetic variation with schizophrenia risk., PMID:35987687
Functional dissection of human mitotic genes using CRISPR-Cas9 tiling screens., PMID:35483740
The Sin3A/MAD1 Complex, through Its PAH2 Domain, Acts as a Second Repressor of Retinoic Acid Receptor Beta Expression in Breast Cancer Cells., PMID:35406744
PSMA as a Theranostic Target in Hepatocellular Carcinoma: Immunohistochemistry and 68 Ga-PSMA-11 PET Using Cyclotron-Produced 68 Ga., PMID:34783177
PIGN spatiotemporally regulates the spindle assembly checkpoint proteins in leukemia transformation and progression., PMID:34561473
MAD1L1 and TSNARE gene polymorphisms are associated with schizophrenia susceptibility in the Han Chinese population., PMID:34481484
DNA methylome in visceral adipose tissue can discriminate patients with and without colorectal cancer., PMID:34311674
Mapping Proximity Associations of Core Spindle Assembly Checkpoint Proteins., PMID:34087075
Long non-coding RNA NORAD upregulation induced by airborne particulate matter (PM10) exposure leads to aneuploidy in A549 lung cells., PMID:33250223
Involvement of NEK2 and its interaction with NDC80 and CEP250 in hepatocellular carcinoma., PMID:33109182
Prognostic Significance of the MAD1L1 1673 G: A Polymorphism in Ovarian Adenocarcinomas., PMID:33052898
Mitotic checkpoint protein Mad1 is required for early Nup153 recruitment to chromatin and nuclear envelope integrity., PMID:33023979
Kinetochore protein MAD1 participates in the DNA damage response through ataxia-telangiectasia mutated kinase-mediated phosphorylation and enhanced interaction with KU80., PMID:32944396
Rashomon at the kinetochore: Function(s) of the Mad1-cyclin B1 complex., PMID:32614383
Twist1 induces chromosomal instability (CIN) in colorectal cancer cells., PMID:32337580
Cyclin B1-Cdk1 facilitates MAD1 release from the nuclear pore to ensure a robust spindle checkpoint., PMID:32236513
Cyclin B1 scaffolds MAD1 at the kinetochore corona to activate the mitotic checkpoint., PMID:32202322
Longitudinal epigenome-wide association studies of three male military cohorts reveal multiple CpG sites associated with post-traumatic stress disorder., PMID:31931860
Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis., PMID:31710517
An algorithm-based meta-analysis of genome- and proteome-wide data identifies a combination of potential plasma biomarkers for colorectal cancer., PMID:31666584
Association of MAD1L1 polymorphism (rs871925) with prenatal famine exposure and schizophrenia in a Chinese population: A case-control study., PMID:31498969
Epigenome-wide association study of depression symptomatology in elderly monozygotic twins., PMID:31477683
Orchestration of the spindle assembly checkpoint by CDK1-cyclin B1., PMID:31469407
ULK1 phosphorylates Mad1 to regulate spindle assembly checkpoint., PMID:31291454
Spindle checkpoint silencing at kinetochores with submaximal microtubule occupancy., PMID:31138679
Mad1 destabilizes p53 by preventing PML from sequestering MDM2., PMID:30948704
Epigenetic Associations With Estimated Glomerular Filtration Rate Among Men With Human Immunodeficiency Virus Infection., PMID:30893429
Towards precision medicine for stress disorders: diagnostic biomarkers and targeted drugs., PMID:30862937
For research use only. Not for human or drug use.
