Catalog No.
YHB26501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Asp230
Predicted molecular weight
26.83 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O75608
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
APT1, LYPLA1, LPL-I, Lysophospholipase I, LysoPLA I, LPL1, hAPT1, Acyl-protein thioesterase 1, APT-1, Lysophospholipase 1
ZDHHC3-LYPLA1 regulates PRRSV-2 replication through reversible palmitoylation., PMID:39787744
Comprehensive identification of ubiquitin-like 3 (UBL3)-interacting proteins in the mouse brain., PMID:39148092
Caveolin-2 palmitoylation turnover facilitates insulin receptor substrate-1-directed lipid metabolism by insulin receptor tyrosine kinase., PMID:38631410
A conserved but structurally divergent loop in acyl protein thioesterase 1 regulates its catalytic activity, ligand binding, and folded stability., PMID:38179877
S-acylation regulates SQSTM1/p62-mediated selective autophagy., PMID:38124295
Hepatocyte CD36 modulates UBQLN1-mediated proteasomal degradation of autophagic SNARE proteins contributing to septic liver injury., PMID:37014234
Hypoxia-induced GPCPD1 depalmitoylation triggers mitophagy via regulating PRKN-mediated ubiquitination of VDAC1., PMID:36803235
Flotillin-1 palmitoylation turnover by APT-1 and ZDHHC-19 promotes cervical cancer progression by suppressing IGF-1 receptor desensitization and proteostasis., PMID:36257975
Broad-acting therapeutic effects of miR-29b-chitosan on hypertension and diabetic complications., PMID:35965413
Weighted Single-Step Genome-Wide Association Study Uncovers Known and Novel Candidate Genomic Regions for Milk Production Traits and Somatic Cell Score in Valle del Belice Dairy Sheep., PMID:35565582
A defective lysophosphatidic acid-autophagy axis increases miscarriage risk by restricting decidual macrophage residence., PMID:35220880
Comprehensive analysis of transcriptomics and metabolomics to illustrate the underlying mechanism of helenalin against hepatic fibrosis., PMID:35120860
LncRNA LOXL1-AS1 Facilitates the Oncogenic Character in Cervical Cancer by the miR-526b-5p /LYPLA1 Axis., PMID:34984578
Protein Palmitoylation in Bovine Ovarian Follicle., PMID:34769186
Chemical proteomic analysis of palmostatin beta-lactone analogs that affect N-Ras palmitoylation., PMID:34666187
Engineering Extracellular Vesicles Enriched with Palmitoylated ACE2 as COVID-19 Therapy., PMID:34665481
RNF141 interacts with KRAS to promote colorectal cancer progression., PMID:34345014
Enterococcus faecalis contributes to hypertension and renal injury in Sprague-Dawley rats by disturbing lipid metabolism., PMID:33967216
In a mouse model of INCL reduced S-palmitoylation of cytosolic thioesterase APT1 contributes to microglia proliferation and neuroinflammation., PMID:33739454
Androgen-dependent miR-125a-5p targets LYPLA1 and regulates global protein palmitoylation level in late-onset hypogonadism males., PMID:33284463
Rapid Solid-Phase Construction of Serine Hydrolase Probes Results in Selective Activity-Based Probes for Acyl Protein Thioesterases-1/2., PMID:32990443
Site-specific deacylation by ABHD17a controls BK channel splice variant activity., PMID:32913120
Lipid and protein tumor markers for head and neck squamous cell carcinoma identified by imaging mass spectrometry., PMID:32733643
The binding of the APT1 domains to phosphoinositides is regulated by metal ions in vitro., PMID:32407779
A metabonomics and lipidomics based network pharmacology study of qi-tonifying effects of honey-processed Astragalus on spleen qi deficiency rats., PMID:32330807
Endothelial Palmitoylation Cycling Coordinates Vessel Remodeling in Peripheral Artery Disease., PMID:32233916
Identifying the Potential Substrates of the Depalmitoylation Enzyme Acyl-protein Thioesterase 1., PMID:30914023
Urine Angiotensin II Signature Proteins as Markers of Fibrosis in Kidney Transplant Recipients., PMID:30801542
Lysophospholipases cooperate to mediate lipid homeostasis and lysophospholipid signaling., PMID:30482805
Inhibition of cell proliferation and migration in non‑small cell lung cancer cells through the suppression of LYPLA1., PMID:30431103
Synthetic Fluorogenic Peptides Reveal Dynamic Substrate Specificity of Depalmitoylases., PMID:30393067
Tissue-specific effects of targeted mutation of Mir29b1 in rats., PMID:30120082
Palmitoylation signaling: a novel mechanism of mitochondria dynamics and diverse pathologies., PMID:29924300
Pool-based genome-wide association study identified novel candidate regions on BTA9 and 14 for oleic acid percentage in Japanese Black cattle., PMID:29770990
Wnt5a signaling induced phosphorylation increases APT1 activity and promotes melanoma metastatic behavior., PMID:29648538
Wogonoside induces depalmitoylation and translocation of PLSCR1 and N-RAS in primary acute myeloid leukaemia cells., PMID:29377576
Active and dynamic mitochondrial S-depalmitoylation revealed by targeted fluorescent probes., PMID:29362370
The depalmitoylase APT1 directs the asymmetric partitioning of Notch and Wnt signaling during cell division., PMID:29295957
Protein depalmitoylases., PMID:29239216
Lyplal1 is dispensable for normal fat deposition in mice., PMID:29084768
A Fluorescent Probe with Improved Water Solubility Permits the Analysis of Protein S-Depalmitoylation Activity in Live Cells., PMID:29023093
Molecular Mechanism for Isoform-Selective Inhibition of Acyl Protein Thioesterases 1 and 2 (APT1 and APT2)., PMID:27748579
Full-Length cDNA Cloning, Molecular Characterization and Differential Expression Analysis of Lysophospholipase I from Ovis aries., PMID:27483239
S-Palmitoylation of a Novel Site in the β2-Adrenergic Receptor Associated with a Novel Intracellular Itinerary., PMID:27481942
Effects of Obesity Related Genetic Variations on Visceral and Subcutaneous Fat Distribution in a Chinese Population., PMID:26848030
Acyl protein thioesterase 1 and 2 (APT-1, APT-2) inhibitors palmostatin B, ML348 and ML349 have different effects on NRAS mutant melanoma cells., PMID:26771141
Quantitative Proteomic Analysis of BHK-21 Cells Infected with Foot-and-Mouth Disease Virus Serotype Asia 1., PMID:26161868
Proteomics analysis of malignant and benign prostate tissue by 2D DIGE/MS reveals new insights into proteins involved in prostate cancer., PMID:26074449
Protein Depalmitoylation Is Induced by Wnt5a and Promotes Polarized Cell Behavior., PMID:25944911
Enzymatic protein depalmitoylation by acyl protein thioesterases., PMID:25849916
For research use only. Not for human or drug use.
