Catalog No.
YHK63101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys135-Gly303
Predicted molecular weight
21.80 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q96L50
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
4-1BBlrr, LRR1, PPIL5, Peptidylprolyl isomerase-like 5, 4-1BB-mediated-signaling molecule, LRR-repeat protein 1, LRR-1, Leucine-rich repeat protein 1
A novel oncogene, leucine-rich repeat protein 1, mediates hypoxia-induced hepatocellular carcinoma progression., PMID:40459634
LRR1 involved in the abscisic acid signaling pathway to regulate the early growth and development of Arabidopsis thaliana., PMID:39619177
Toll-like receptor 21 in Labeo rohita recognizes double-stranded RNA and lipopolysaccharides by engaging the critical motifs in the LRR domain and gets activated against bacterial assaults., PMID:39191145
RNF8-mediated multi-ubiquitination of MCM7: Linking disassembly of the CMG helicase with DNA damage response in human cells., PMID:39004272
Three-Dimensional Modeling of CpG DNA Binding with Matrix Lumican Shows Leucine-Rich Repeat Motif Involvement as in TLR9-CpG DNA Interactions., PMID:37834438
3D modeling of CpG DNA binding with matrix lumican shows leucine-rich repeat motif involvement as in TLR9-CpG DNA interactions., PMID:37662233
Plasmodium berghei leucine-rich repeat protein 1 downregulates protein phosphatase 1 activity and is required for efficient oocyst development., PMID:35920043
The p97 segregase cofactor Ubxn7 facilitates replisome disassembly during S-phase., PMID:35798141
Engineering Chimeras by Fusing Plant Receptor-like Kinase EMS1 and BRI1 Reveals the Two Receptors' Structural Specificity and Molecular Mechanisms., PMID:35216268
Structure of CRL2Lrr1, the E3 ubiquitin ligase that promotes DNA replication termination in vertebrates., PMID:34850944
A conserved mechanism for regulating replisome disassembly in eukaryotes., PMID:34700328
Reconstitution of human CMG helicase ubiquitylation by CUL2LRR1 and multiple E2 enzymes., PMID:34195792
LRR1-mediated replisome disassembly promotes DNA replication by recycling replisome components., PMID:34037657
CUL2LRR1 , TRAIP and p97 control CMG helicase disassembly in the mammalian cell cycle., PMID:33590678
Arabidopsis U-box E3 ubiquitin ligase PUB11 negatively regulates drought tolerance by degrading the receptor-like protein kinases LRR1 and KIN7., PMID:33347703
Structural analysis of toll-like receptor 18 from soiny mullet (Liza haematocheila): Giving insights on the ligand binding mechanism of fish specific TLRs., PMID:33098989
The DNA replication fork suppresses CMG unloading from chromatin before termination., PMID:32943574
Identification and characterization of endosymbiosis-related immune genes in deep-sea mussels Gigantidas platifrons., PMID:32834906
The Protective Effect of Low Dose of Lipopolysaccharide Pretreatment on Endotoxin-Induced Uveitis in Rats Is Associated with Downregulation of CSF-1 and Upregulation of LRR-1., PMID:32671118
Mechanisms of eukaryotic replisome disassembly., PMID:32490508
The Roles of Cullin-2 E3 Ubiquitin Ligase Complex in Cancer., PMID:31898228
Geminivirus C4 antagonizes the HIR1-mediated hypersensitive response by inhibiting the HIR1 self-interaction and promoting degradation of the protein., PMID:31537050
Structure-Function Analysis of Immune Receptor AtRLP23 with Its Ligand nlp20 and Coreceptors AtSOBIR1 and AtBAK1., PMID:31237473
Mitotic replisome disassembly depends on TRAIP ubiquitin ligase activity., PMID:30979826
Preface., PMID:30834828
Sequence and functional variability of Toll-like receptor 9 gene in equines., PMID:30503611
LGI1 antibodies alter Kv1.1 and AMPA receptors changing synaptic excitability, plasticity and memory., PMID:30346486
Multiple Aspects of PIP2 Involvement in C. elegans Gametogenesis., PMID:30201859
The versatile functions of LRR-only proteins in mollusk Chlamys farreri., PMID:28807724
Silencing of the Rice Gene LRR1 Compromises Rice Xa21 Transcript Accumulation and XA21-Mediated Immunity., PMID:28534133
CUL-2LRR-1 and UBXN-3 drive replisome disassembly during DNA replication termination and mitosis., PMID:28368371
CRL2Lrr1 promotes unloading of the vertebrate replisome from chromatin during replication termination., PMID:28235849
Co-expressed differentially expressed genes and long non-coding RNAs involved in the celecoxib treatment of gastric cancer: An RNA sequencing analysis., PMID:27698747
RNAi-Based Suppressor Screens Reveal Genetic Interactions Between the CRL2LRR-1 E3-Ligase and the DNA Replication Machinery in Caenorhabditis elegans., PMID:27543292
The structure and regulation of Cullin 2 based E3 ubiquitin ligases and their biological functions., PMID:27222660
Distribution and Evolution of Yersinia Leucine-Rich Repeat Proteins., PMID:27217422
Atlas on substrate recognition subunits of CRL2 E3 ligases., PMID:27107416
Structure of Slitrk2-PTPδ complex reveals mechanisms for splicing-dependent trans-synaptic adhesion., PMID:25989451
Structural basis for LAR-RPTP/Slitrk complex-mediated synaptic adhesion., PMID:25394468
Selection of the lamprey VLRC antigen receptor repertoire., PMID:25228760
Role of the CRL2(LRR-1) E3 ubiquitin-ligase in the development of the germline in C. elegans., PMID:24778939
Crystal structure of an engineered YopM-InlB hybrid protein., PMID:24669959
Structural insights into the inhibition of Wnt signaling by cancer antigen 5T4/Wnt-activated inhibitory factor 1., PMID:24582434
Genome wide analysis indicates genes for basement membrane and cartilage matrix proteins as candidates for hip dysplasia in Labrador Retrievers., PMID:24498183
Pathogenesis-related protein 4b interacts with leucine-rich repeat protein 1 to suppress PR4b-triggered cell death and defense response in pepper., PMID:24304389
Reconstitution of R-spondin:LGR4:ZNRF3 adult stem cell growth factor signaling complexes with recombinant proteins produced in Escherichia coli., PMID:24050775
Activation of nucleotide-binding oligomerization domain 1 (NOD1) receptor signaling in Labeo rohita by iE-DAP and identification of ligand-binding key motifs in NOD1 by molecular modeling and docking., PMID:23657901
PTPN14 is required for the density-dependent control of YAP1., PMID:22948661
Requirement of the cytosolic interaction between PATHOGENESIS-RELATED PROTEIN10 and LEUCINE-RICH REPEAT PROTEIN1 for cell death and defense signaling in pepper., PMID:22492811
CRL2(LRR-1) targets a CDK inhibitor for cell cycle control in C. elegans and actin-based motility regulation in human cells., PMID:21074724
For research use only. Not for human or drug use.
