Catalog No.
YHK62901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Lys141
Predicted molecular weight
18.06 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q969G2
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
LHX4, LIM/homeobox protein Lhx4, LIM homeobox protein 4
Primary Cilia are Required for Cell-Type Determination and Angiogenesis in Pituitary Development., PMID:39001875
Combined Pituitary Hormone Deficiency in lhx4-Knockout Zebrafish., PMID:39000439
Lhx4 surpasses its paralog Lhx3 in promoting the differentiation of spinal V2a interneurons., PMID:38970652
Genetic diagnosis of congenital hypopituitarism in Turkish patients by a target gene panel: novel pathogenic variants in GHRHR, GLI2, LHX4 and POU1F1 genes., PMID:37948564
Identification of genetic variants and phenotypic characterization of a large cohort of patients with congenital hypopituitarism and related disorders., PMID:37165954
The Genetic Landscape of Children Born Small for Gestational Age with Persistent Short Stature., PMID:37019085
Whole Exome Sequencing Points towards a Multi-Gene Synergistic Action in the Pathogenesis of Congenital Combined Pituitary Hormone Deficiency., PMID:35805171
A human paradigm of LHX4 and NR5A1 developmental gene interaction in the pituitary gland and ovary?, PMID:35277652
Global gene expression profiling in congenital diaphragmatic hernia (CDH) patients., PMID:35260975
Asymmetric Distributions of Achromatic Bipolar Cells in the Mouse Retina., PMID:35095431
Novel gross deletion at the LHX4 gene locus in a child with growth hormone deficiency., PMID:34971854
LIM Homeodomain (LIM-HD) Genes and Their Co-Regulators in Developing Reproductive System and Disorders of Sex Development., PMID:34518474
The role of homeobox gene-encoded transcription factors in regulation of phototransduction: Implementing the primary pinealocyte culture as a photoreceptor model., PMID:34129741
Occurrence of Hypopituitarism in Tunisian Turner Syndrome patients: familial versus sporadic cases., PMID:34124982
Comprehensive Identification of Pathogenic Gene Variants in Patients With Neuroendocrine Disorders., PMID:33729509
LIM Homeobox 4 (lhx4) regulates retinal neural differentiation and visual function in zebrafish., PMID:33479361
Clinical lessons learned in constitutional hypopituitarism from two decades of experience in a large international cohort., PMID:33098107
LIM-Homeodomain Transcription Factor LHX4 Is Required for the Differentiation of Retinal Rod Bipolar Cells and OFF-Cone Bipolar Subtypes., PMID:32937137
[Thyroid disruptor p, p'-DDE inhibited the expression of LHX4 and DIS3L protein in Nthy-ori-3-1 cells]., PMID:32892578
Identification of novel candidate pathogenic genes in pituitary stalk interruption syndrome by whole-exome sequencing., PMID:32864857
SEMA3A and IGSF10 Are Novel Contributors to Combined Pituitary Hormone Deficiency (CPHD)., PMID:32612575
Histone deacetylase 1 and 2 drive differentiation and fusion of progenitor cells in human placental trophoblasts., PMID:32366868
The transcriptional regulator CBX2 and ovarian function: A whole genome and whole transcriptome approach., PMID:31745224
The Lhx4 homeobox transcript in the rat pineal gland: Adrenergic regulation and impact on transcripts encoding melatonin-synthesizing enzymes., PMID:31609018
Generation and characterization of Lhx4tdT reporter knock-in and Lhx4loxP conditional knockout mice., PMID:31313880
Identification of Genes With Enriched Expression in Early Developing Mouse Cone Photoreceptors., PMID:31260032
Genetic analysis of adult Slovenian patients with combined pituitary hormone deficiency., PMID:31093944
Mutation in a flexible linker modulates binding affinity for modular complexes., PMID:30788856
Screening a large pediatric cohort with GH deficiency for mutations in genes regulating pituitary development and GH secretion: Frequencies, phenotypes and growth outcomes., PMID:30266296
Pre- and post-puberty expression of genes and proteins in the uterus of Bos indicus heifers: the luteal phase effect post-puberty., PMID:30192028
Hypothalamic sonic hedgehog is required for cell specification and proliferation of LHX3/LHX4 pituitary embryonic precursors., PMID:28807898
Genetic Polymorphisms as Predictive Markers of Response to Growth Hormone Therapy in Children with Growth Hormone Deficiency., PMID:28806841
Molecular genetics of growth hormone deficient children: correlation with auxology and response to first year of growth hormone therapy., PMID:28525353
Pituitary Hypoplasia., PMID:28476222
Combined pituitary hormone deficiency due to gross deletions in the POU1F1 (PIT-1) and PROP1 genes., PMID:28356564
Rare Frequency of Mutations in Pituitary Transcription Factor Genes in Combined Pituitary Hormone or Isolated Growth Hormone Deficiencies in Korea., PMID:28332357
Whole-exome sequencing identifies compound heterozygous LHX4 mutations in a fetus with early-onset growth restriction., PMID:28262278
Classical and non-classical causes of GH deficiency in the paediatric age., PMID:27974186
Genetic causes of isolated and combined pituitary hormone deficiency., PMID:27974184
Contribution of LHX4 Mutations to Pituitary Deficits in a Cohort of 417 Unrelated Patients., PMID:27820671
ISL1-based LIM complexes control Slit2 transcription in developing cranial motor neurons., PMID:27819291
GENETIC DISORDERS OF PITUITARY DEVELOPMENT IN PATIENTS WITH SHEEHAN'S SYNDROME., PMID:31149124
Long-Term Outcomes, Genetics, and Pituitary Morphology in Patients with Isolated Growth Hormone Deficiency and Multiple Pituitary Hormone Deficiencies: A Single-Centre Experience of Four Decades of Growth Hormone Replacement., PMID:27487097
LHX4 Gene Alterations: Patient Report and Review of the Literature., PMID:27464418
Hypopituitarism: An uncommon cause of developmental delay., PMID:27452620
Two coexisting heterozygous frameshift mutations in PROP1 are responsible for a different phenotype of combined pituitary hormone deficiency., PMID:26608600
Frequency of genetic defects in combined pituitary hormone deficiency: a systematic review and analysis of a multicentre Italian cohort., PMID:26147833
Identifying the Deleterious Effect of Rare LHX4 Allelic Variants, a Challenging Issue., PMID:25955177
Novel Lethal Form of Congenital Hypopituitarism Associated With the First Recessive LHX4 Mutation., PMID:25871839
Growth hormone deficiency in monozygotic twins with autosomal dominant pseudohypoparathyroidism type Ib., PMID:25843330
For research use only. Not for human or drug use.
