Catalog No.
YHG62501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg214-Thr260
Predicted molecular weight
17.67 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13639
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
HTR4, Serotonin receptor 4, 5-HT-4, 5-HT4, 5-hydroxytryptamine receptor 4
Polysaccharide from Aloe vera gel improves intestinal stem cells dysfunction to alleviate intestinal barrier damage via 5-HT., PMID:40467243
Rotenone Induces Parkinsonism with Constipation Symptoms in Mice by Disrupting the Gut Microecosystem, Inhibiting the PI3K-AKT Signaling Pathway and Gastrointestinal Motility., PMID:40076704
5-Hydroxytryptamine G-Protein-Coupled Receptor Family Genes: Key Players in Cancer Prognosis, Immune Regulation, and Therapeutic Response., PMID:39766808
The microRNA-29ab1/Zfp36/AR Axis in the Hypothalamus Regulates Male-Typical Behaviors in Mice., PMID:39684798
Downregulation of MGLL and microRNAs (miR-302b-5p, miR-190a-3p, miR-450a-2-3p) in non-small cell lung cancer: potential roles in pathogenesis., PMID:39673541
GR113808, a serotonin receptor 4 antagonist, prevents high-fat-diet-induced obesity, fatty liver formation, and insulin resistance in C57BL/6J mice., PMID:39394150
Transcriptome analysis elucidates mating affects the expression of intra-/extra-ovarian factors, thereby influencing ovarian development in the mud crab Scylla paramamosain., PMID:39378790
Microbiota influence on behavior: Integrative analysis of serotonin metabolism and behavioral profile in germ-free mice., PMID:38822661
Effect of Short Photoperiod on Behavior and Brain Plasticity in Mice Differing in Predisposition to Catalepsy: The Role of BDNF and Serotonin System., PMID:38473717
Chronic intestinal pseudo-obstruction: associations with gut microbiota and genes expression of intestinal serotonergic pathway., PMID:38302874
Serotonin receptor 4 agonism prevents high fat diet induced reduction in GLP-1 in mice., PMID:37926275
Weighted single-step genome-wide association study and functional enrichment analyses for gastrointestinal nematode resistance traits in Santa Ines sheep., PMID:37857178
The impact of Akkermansia muciniphila and its extracellular vesicles in the regulation of serotonergic gene expression in a small intestine of mice., PMID:37797929
Identification, characterization, and transcription of serotonin receptors in rainbow trout (Oncorhynchus mykiss) in response to bacterial infection and salinity changes., PMID:37481174
Limosilactobacillus mucosae and Lactobacillus amylovorus Protect Against Experimental Colitis via Upregulation of Colonic 5-Hydroxytryptamine Receptor 4 and Transforming Growth Factor-β2., PMID:37356501
Deficiency of HTR4 and ADRB1 caused by SARS-CoV-2 spike may partially explain multiple COVID-19 related syndromes including depression, cognitive impairment, loss of appetite, heart failure, and hypertension., PMID:36471519
Expression of 5-HT Relates to Stem Cell Marker LGR5 in Patients with Gastritis and Gastric Cancer., PMID:36436157
Habenula as a Possible Target for Treatment-Resistant Depression Phenotype in Wistar Kyoto Rats., PMID:36344870
Serotonin receptor expression in hippocampus and temporal cortex of temporal lobe epilepsy patients by postictal generalized electroencephalographic suppression duration., PMID:36053862
Transcriptome profiling of kisspeptin neurons from the mouse arcuate nucleus reveals new mechanisms in estrogenic control of fertility., PMID:35763574
Functional expression of opioid receptors and other human GPCRs in yeast engineered to produce human sterols., PMID:35610225
Tegaserod Maleate Inhibits Breast Cancer Progression and Enhances the Sensitivity of Immunotherapy., PMID:35154317
The GG genotype of the serotonin 4 receptor genetic polymorphism, rs1345697, is associated with lower remission rates after antidepressant treatment: Findings from the METADAP cohort., PMID:34906639
Age-Related Alterations in the Behavior and Serotonin-Related Gene mRNA Levels in the Brain of Males and Females of Short-Lived Turquoise Killifish (Nothobranchius furzeri)., PMID:34680051
The Bioinformatics Analysis of Aldosterone-Producing Adenoma and Verification of Differentially Expressed Genes., PMID:34675975
Constitutive Serotonin Tone Modulates Molecular and Behavioral Response to Chronic Fluoxetine Treatment: A Study on Genetic Rat Model., PMID:34658974
Construction of Potential Gene Expression and Regulation Networks in Prostate Cancer Using Bioinformatics Tools., PMID:34512870
Lactobacillus plantarum PS128 Promotes Intestinal Motility, Mucin Production, and Serotonin Signaling in Mice., PMID:34327633
The 5-HT4 receptor interacts with adhesion molecule L1 to modulate morphogenic signaling in neurons., PMID:33536244
The dorsal arcopallium of chicks displays the expression of orthologs of mammalian fear related serotonin receptor subfamily genes., PMID:33273690
Expression of serotonin receptor HTR4 in glucagon-like peptide-1-positive enteroendocrine cells of the murine intestine., PMID:32870377
Duodenal mucosal secretory disturbances in functional dyspepsia., PMID:32776463
Asymmetric distribution of pallial-expressed genes in zebrafish (Danio rerio)., PMID:32692463
FSH signaling is involved in affective disorders., PMID:32171529
Repurposing the serotonin agonist Tegaserod as an anticancer agent in melanoma: molecular mechanisms and clinical implications., PMID:32085796
Association of human serotonin receptor 4 promoter methylation with autism spectrum disorder., PMID:31977880
Down-regulation effects of IFN-α on p11, 5-htr1b and 5-HTR4 protein levels were affected by NH4CL or MG132 treatment in SH-sy5y cells., PMID:31502579
Hesperidin Improves Colonic Motility in Loeramide-Induced Constipation Rat Model via 5-Hydroxytryptamine 4R/cAMP Signaling Pathway., PMID:31454820
Serotonin receptor 3B polymorphisms are associated with type 2 diabetes: The Korean Genome and Epidemiology Study., PMID:31152805
Short communication: Differences in distribution of serotonin receptor subtypes in the mammary gland of sheep, goats, and cows during lactation and involution., PMID:30639027
Calcium Pyruvate Exerts Beneficial Effects in an Experimental Model of Irritable Bowel Disease Induced by DCA in Rats., PMID:30634696
The role of serotonin and its receptors on the anticonvulsant effect of curcumin in pentylenetetrazol-induced seizures., PMID:30243647
[Metabolic analysis of serotonin system in serum and gastric tissues of ovalbumin-induced allergic mice]., PMID:29973322
Intracellular GPCRs Play Key Roles in Synaptic Plasticity., PMID:29409317
Identify Down syndrome transcriptome associations using integrative analysis of microarray database and correlation-interaction network., PMID:29351810
miR-16 and miR-103 impact 5-HT4 receptor signalling and correlate with symptom profile in irritable bowel syndrome., PMID:29089619
[Polymorphic Variants of Glutamate Receptor (GRIK5, GRIN2B) and Serotonin Receptor (HTR2A) Genes Are Associated with Chronic Obstructive Pulmonary Disease]., PMID:28900078
Aberrant G protein-receptor expression is associated with DNA methylation in aldosterone-producing adenoma., PMID:28870781
Serotonin receptor 4 (5-hydroxytryptamine receptor Type 4) regulates expression of estrogen receptor beta and cell migration in hormone-naive prostate cancer., PMID:28195088
Vagal innervation is required for pulmonary function phenotype in Htr4-/- mice., PMID:28130264
For research use only. Not for human or drug use.
