Catalog No.
YHK62801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys97-Gln170
Predicted molecular weight
20.49 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UJY1
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CRYAC, E2IG1, Heat shock protein beta-8, Protein kinase H11, Small stress protein-like protein HSP22, HSP22, E2-induced gene 1 protein, HSPB8, Alpha-crystallin C chain, HspB8
Novel HSPB8 mutations in severe early-onset myopathy with involvement of respiratory and cardiac muscles cause proteostasis defects in cell models., PMID:40467930
Pathogenic mechanism of the K141E mutation in HSPB8: Insights from smFRET and simulations., PMID:40449653
The Spectrum of Small Heat Shock Protein B8 (HSPB8)-Associated Neuromuscular Disorders., PMID:40243504
Small heat shock protein HSPB8 interacts with a pre-fibrillar TDP43 low complexity domain species to delay fibril formation., PMID:39974920
RNA Interference Targeting Small Heat Shock Protein B8 Failed to Improve Distal Hereditary Motor Neuropathy in the Mouse Model., PMID:39972648
Interaction of small heat shock proteins with BAG3., PMID:39814164
HSP90 Family Members, Their Regulators and Ischemic Stroke Risk: A Comprehensive Molecular-Genetics and Bioinformatics Analysis., PMID:39736019
Silencing miR-126-5p protects trabecular meshwork cells against chronic oxidative injury by upregulating HSPB8 to activate PI3K/AKT pathway., PMID:39729156
Autophagy induction by piplartine ameliorates axonal degeneration caused by mutant HSPB1 and HSPB8 in Charcot-Marie-Tooth type 2 neuropathies., PMID:39698979
Expanding the spectrum of HSPB8-related myopathy: a novel mutation causing atypical pediatric-onset axial and limb-girdle involvement with autophagy abnormalities and molecular dynamics studies., PMID:39548192
Small heat shock protein B8: from cell functions to its involvement in diseases and potential therapeutic applications., PMID:39435632
HSPB8-BAG3 chaperone complex modulates cell invasion in intrahepatic cholangiocarcinoma by regulating CASA-mediated Filamin A degradation., PMID:39215616
The role of heat shock protein B8 in neuronal protection against oxidative stress and mitochondrial dysfunction: A literature review., PMID:39094362
HSPB8 attenuates lipopolysaccharide‑mediated acute lung injury in A549 cells by activating mitophagy., PMID:39054966
Molecular insights into programmed cell death in esophageal squamous cell carcinoma., PMID:39006030
The ischemia-enhanced myocardial infarction protection-related lncRNA protects against acute myocardial infarction., PMID:38988491
Identification of Alternatively Spliced Novel Isoforms of Human HSPB8 Gene., PMID:38980537
Sialyltransferase ST3GAL6 silencing reduces α2,3-sialylated glycans to regulate autophagy by decreasing HSPB8-BAG3 in the brain with hepatic encephalopathy., PMID:38910494
Comprehensive analysis of autophagy associated genes and immune infiltrates in cervical cancer., PMID:38800011
Reduction of Filamin C Results in Altered Proteostasis, Cardiomyopathy, and Arrhythmias., PMID:38761081
HSPB8 binding to c-Myc alleviates hypoxia/reoxygenation-induced trophoblast cell dysfunction., PMID:38361516
Heat Shock Protein 22 Attenuates Nerve Injury-induced Neuropathic Pain Via Improving Mitochondrial Biogenesis and Reducing Oxidative Stress Mediated By Spinal AMPK/PGC-1α Pathway in Male Rats., PMID:38319409
HSPB8 Facilitates the Oncogenesis and Advancement of Bladder Cancer via Activation of HSP27., PMID:38213722
Genetic and Pharmacological Modulation of Cellular Proteostasis Leads to Partial Functional Rescue of Homocystinuria-Causing Cystathionine-Beta Synthase Variants., PMID:38051092
Interaction of the C-terminal immunoglobulin-like domains (Ig 22-24) of filamin C with human small heat shock proteins., PMID:38016530
PINK1 and Parkin rescue motor defects and mitochondria dysfunction induced by a patient-derived HSPB3 mutant in Drosophila models., PMID:37804589
Differentially Expressed mRNA in Streptozotocin-Induced Diabetic Bladder Using RNA Sequencing Analysis., PMID:37798882
In-vitro immunomodulatory responses and antiviral activities of antimicrobial peptide octominin against fish pathogenic viruses., PMID:37777098
Dexmedetomidine Promoted HSPB8 Expression via Inhibiting the lncRNA SNHG14/UPF1 Axis to Inhibit Apoptosis of Nerve Cells in AD : The Role of Dexmedetomidine in AD., PMID:37656385
Oncogenic DNA methyltransferase 1 activates the PI3K/AKT/mTOR signalling by blocking the binding of HSPB8 and BAG3 in melanoma., PMID:37523636
HSPB8-Mediated Actin Filament Reorganization by Promoting Autophagic Flux Confers Resilience to Blood-Brain Barrier (BBB) Injury in an In Vitro Model of Ischemic Stroke., PMID:37522952
Eukaryotic Elongation Factor 1Alpha-2 (EEF1A2) Participates in the Progression of Gastric Cancer via Interaction with Heat Shock Protein B8 (HSPB8)., PMID:37437931
Human Small Heat Shock Protein B8 Inhibits Protein Aggregation without Affecting the Native Folding Process., PMID:37411010
HSPB8 up-regulation alleviates cognitive dysfunction in a mouse model of sepsis-associated encephalopathy., PMID:37399610
Inhibition of Histone H3K18 Acetylation-Dependent Antioxidant Pathways Involved in Arsenic-Induced Liver Injury in Rats and the Protective Effect of Rosa roxburghii Tratt Juice., PMID:37368603
Drug resistance related genes in lung adenocarcinoma predict patient prognosis and influence the tumor microenvironment., PMID:37322027
HspB8 interacts with BAG3 in a "native-like" conformation forming a complex that displays chaperone-like activity., PMID:37243950
Hyperthermia promotes M1 polarization of macrophages via exosome-mediated HSPB8 transfer in triple negative breast cancer., PMID:37233869
Molecular Chaperones' Potential against Defective Proteostasis of Amyotrophic Lateral Sclerosis., PMID:37174703
Genome-wide expression analysis reveals different heat shock responses in indigenous (Bos indicus) and crossbred (Bos indicus X Bos taurus) cattle., PMID:37127630
C-Terminal Truncated HBx Facilitates Oncogenesis by Modulating Cell Cycle and Glucose Metabolism in FXR-Deficient Hepatocellular Carcinoma., PMID:36982249
PINK1 and Parkin Ameliorate the Loss of Motor Activity and Mitochondrial Dysfunction Induced by Peripheral Neuropathy-Associated HSPB8 Mutants in Drosophila Models., PMID:36979812
Hsp22 pretreatment protects against LPS-induced hippocampal injury by alleviating neuroinflammation and apoptosis by regulating the NLRP3/Caspase1/IL-1β signaling pathway in mice., PMID:36934348
Macrophage-specific autophagy-related gene HSPB8 is involved in the macrophage polarization in atherosclerosis., PMID:36934244
CircAGO2 promotes colorectal cancer progression by inhibiting heat shock protein family B (small) member 8 via miR-1-3p/retinoblastoma binding protein 4 axis., PMID:36881338
Multisystem proteinopathies (MSPs) and MSP-like disorders: Clinical-pathological-molecular spectrum., PMID:36861178
HSPB8 frameshift mutant aggregates weaken chaperone-assisted selective autophagy in neuromyopathies., PMID:36854646
α-Crystallin Domains of Five Human Small Heat Shock Proteins (sHsps) Differ in Dimer Stabilities and Ability to Incorporate Themselves into Oligomers of Full-Length sHsps., PMID:36674601
DUSP12 ameliorates myocardial ischemia-reperfusion injury through HSPB8-induced mitophagy., PMID:36644958
For research use only. Not for human or drug use.
