Catalog No.
YHH07401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asn11-Ser173
Predicted molecular weight
19.67 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q15365
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PCBP1, Poly(rC)-binding protein 1, Nucleic acid-binding protein SUB2.3, Heterogeneous nuclear ribonucleoprotein E1, Alpha-CP1, hnRNP E1
RNA binding proteins PCBP1 and PCBP2 regulate pancreatic β cell translation., PMID:40451383
ECM1 protects against liver steatosis through PCBP1-mediated iron homeostasis., PMID:40372944
TBBPA induced hepatocyte ferroptosis by PCBP1-mediated ferritinophagy., PMID:40359755
BCAT2 binding to PCBP1 regulates the PI3K/AKT signaling pathway to inhibit autophagy-related apoptosis and ferroptosis in prostate cancer., PMID:40274762
S146 and M148 within the mature chain domain of PSMB4 are crucial for degrading PRRSV nsp1α., PMID:40192860
The role of RAB12 in inhibiting osteogenic differentiation and driving metabolic dysregulation in osteoporosis., PMID:40147529
Research on iron regulatory erythroid factors in children with β-thalassemia., PMID:40103337
Therapeutic strategies to reverse cigarette smoke-induced ion channel and mucociliary dysfunction in COPD airway epithelial cells., PMID:40095970
RNA splicing of the STAT3 by PCBP1 promotes vulnerable plaque formation via macrophage-like phenotype modulation of vascular smooth muscle cell., PMID:39938358
The role of PCBP1 in carbon ion-induced ferroptosis and inhibition of lung adenocarcinoma proliferation., PMID:39845670
Protein nanoparticles as potent delivery vehicles for polycytosine RNA-binding protein one., PMID:39817210
LncRNA MIR210HG promotes the proliferation of colon cancer cells by inhibiting ferroptosis through binding to PCBP1., PMID:39757305
Single-cell RNA sequencing reveals the critical role of alternative splicing in cattle testicular spermatagonia., PMID:39726007
Interrogation of RNA-bound proteome with XRNAX illuminates molecular alterations in the mouse brain affected with dysmyelination., PMID:39709601
Decoding poly (RC)-binding protein 1 (PCBP1), the underrated guard at the foothill of ferroptosis., PMID:39700662
The effector protein BspE affects Brucella survival by regulating the inflammatory response and apoptosis., PMID:39566384
PCBP1/2 and TDP43 Function as NAT10 Adaptors to Mediate mRNA ac4C Formation in Mammalian Cells., PMID:39556689
LncRNA PCBP1-AS1 suppresses cell growth in oral squamous cell carcinoma by targeting miR-34c-5p/ZFP36 axis., PMID:39380272
The RNA-binding protein PCBP1 modulates transcription by recruiting the G-quadruplex-specific helicase DHX9., PMID:39342995
Loss-of-function variant in TDRD6 cause male infertility with severe oligo-astheno-teratozoospermia in human and mice., PMID:39331689
Discovery of an 8-oxoguanine regulator PCBP1 inhibitor by virtual screening and its synergistic effects with ROS-modulating agents in pancreatic cancer., PMID:39170746
A small protein encoded by PCBP1-AS1 is identified as a key regulator of influenza virus replication via enhancing autophagy., PMID:39137200
Macrophage iron dyshomeostasis promotes aging-related renal fibrosis., PMID:39016438
Identification of differentially expressed genes of blood leukocytes for Schizophrenia., PMID:38988837
PRPF40A induces inclusion of exons in GC-rich regions important for human myeloid cell differentiation., PMID:38943321
Hemoglobin Hydrolyzate Promotes Iron Absorption in the Small Intestine through Iron Binding Peptides., PMID:38935870
Polycytosine RNA-binding protein 1 regulates osteoblast function via a ferroptosis pathway in type 2 diabetic osteoporosis., PMID:38766437
Proteomics analysis of PK-15 cells infected with porcine parvovirus and the effect of PCBP1 on PPV replication., PMID:38742903
PCBP1 interacts with the HTLV-1 Tax oncoprotein to potentiate NF-κB activation., PMID:38690287
Alternative splicing of CARM1 regulated by LincGET-guided paraspeckles biases the first cell fate in mammalian early embryos., PMID:38658621
Exocarpium Citri Grandis ameliorates LPS-induced acute lung injury by suppressing inflammation, NLRP3 inflammasome, and ferroptosis., PMID:38588989
LncRNA GAS6-AS1 contributes to 5-fluorouracil resistance in colorectal cancer by facilitating the binding of PCBP1 with MCM3., PMID:38521199
Poly(rC)-binding protein 1 alleviates neurotoxicity in 6-OHDA-induced SH-SY5Y cells and modulates glial cells in neuroinflammation., PMID:38492841
Deciphering alternative splicing events and their therapeutic implications in colorectal Cancer., PMID:38484942
It is not just about transcription: involvement of brain RNA splicing in substance use disorders., PMID:38396082
Investigating the neuroprotective potential of rAAV2-PCBP1-EGFP gene therapy against a 6-OHDA-induced model of Parkinson's disease., PMID:38376022
Elaborate cooperation of poly(rC)-binding proteins 1/2 and glutathione in ferroptosis induced by plasma-activated Ringer's lactate., PMID:38325565
Molecular and functional characterization of porcine poly C binding protein 1 (PCBP1)., PMID:38218813
Serum proteomics reveals a tolerant immune phenotype across multiple pathogen taxa in wild vampire bats., PMID:38193073
RNA-binding proteins that preferentially interact with 8-oxoG-modified RNAs: our current understanding., PMID:38174726
Amyotrophic lateral sclerosis associated disturbance of iron metabolism is blunted by swim training-role of AKT signaling pathway., PMID:38171451
Iron chelation improves ineffective erythropoiesis and iron overload in myelodysplastic syndrome mice., PMID:38153418
Lipopolysaccharide inhibits translation of iron chaperone PCBP1 to regulate inflammatory cytokine response in macrophage., PMID:38061091
Screening and identification of key biomarkers associated with amyotrophic lateral sclerosis and depression using bioinformatics., PMID:38013317
PCBP1 is essential for proper iron absorption., PMID:37944181
PCBP1 regulates LIFR through FAM3C to maintain breast cancer stem cell self-renewal and invasiveness., PMID:37927213
Association of LncRNA PCBP1-AS1 with cancer occurrence and development: A review., PMID:37904442
Role of ferroptosis and immune infiltration in intervertebral disc degeneration: novel insights from bioinformatics analyses., PMID:37736497
The iron chaperone poly(rC)-binding protein 1 regulates iron efflux through intestinal ferroportin in mice., PMID:37624904
Classification of IDH wild-type glioblastoma tumorspheres into low- and high-invasion groups based on their transcriptional program., PMID:37558923
For research use only. Not for human or drug use.
