Catalog No.
YHA42701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr82-Gly503
Predicted molecular weight
49.12 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O15131
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Karyopherin subunit alpha-5, Importin subunit alpha-6, KPNA5
KPNA5 Suppresses Malignant Progression of Ovarian Cancer Through Importing the PTPN4 Into the Nucleus., PMID:40145330
Effect of Ivermectin and Atorvastatin on Nuclear Localization of Importin Alpha and Drug Target Expression Profiling in Host Cells from Nasopharyngeal Swabs of SARS-CoV-2- Positive Patients., PMID:34696514
Molecular profiling of nucleocytoplasmic transport factor genes in breast cancer., PMID:33553736
Regulation of the Ebola Virus VP24 Protein by SUMO., PMID:31597768
Ebolavirus interferon antagonists-protein interaction perspectives to combat pathogenesis., PMID:29140409
Investigating Ebola virus pathogenicity using molecular dynamics., PMID:28812539
Macrocyclic peptide inhibitors for the protein-protein interaction of Zaire Ebola virus protein 24 and karyopherin alpha 5., PMID:28574091
An all-atom molecular dynamics study of the anti-interferon signaling of Ebola virus: interaction mechanisms of EBOV VP24 binding to Karyopherin alpha5., PMID:28418440
VP24-Karyopherin Alpha Binding Affinities Differ between Ebolavirus Species, Influencing Interferon Inhibition and VP24 Stability., PMID:27974555
Conserved differences in protein sequence determine the human pathogenicity of Ebolaviruses., PMID:27009368
In Silico Study of Plant Polyphenols' Interactions with VP24-Ebola Virus Membrane-associated Protein., PMID:26454589
Lloviu virus VP24 and VP35 proteins function as innate immune antagonists in human and bat cells., PMID:26255028
BIG3 Inhibits the Estrogen-Dependent Nuclear Translocation of PHB2 via Multiple Karyopherin-Alpha Proteins in Breast Cancer Cells., PMID:26052702
Global Characteristics of CSIG-Associated Gene Expression Changes in Human HEK293 Cells and the Implications for CSIG Regulating Cell Proliferation and Senescence., PMID:26029164
Cross-platform meta-analysis of multiple gene expression profiles identifies novel expression signatures in acquired anthracycline-resistant breast cancer., PMID:25695524
Ebola virus VP24 targets a unique NLS binding site on karyopherin alpha 5 to selectively compete with nuclear import of phosphorylated STAT1., PMID:25121748
How a virus blocks a cellular emergency access lane to the nucleus, STAT!, PMID:25121743
Somatic mutations in the Notch, NF-KB, PIK3CA, and Hedgehog pathways in human breast cancers., PMID:22302350
Physical map of the chromosome 6q22 region containing the oculodentodigital dysplasia locus: analysis of thirteen candidate genes and identification of novel ESTs and DNA polymorphisms., PMID:12584438