Catalog No.
YHK50701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Pro2-Ala80
Predicted molecular weight
37.20 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8WXU2
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
DYX1C1, EKN1, Dynein assembly factor 4, axonemal, DNAAF4, Dyslexia susceptibility 1 candidate gene 1 protein
Targeted analysis of dyslexia-associated regions on chromosomes 6, 12 and 15 in large multigenerational cohorts., PMID:40424442
Investigation of Association Between Expression of DYX1C1, KIAA0319, and ROBO1 Genes and Specific Learning Disorder in Children and Adolescents., PMID:39542997
Whole genome sequencing enhances molecular diagnosis of primary ciliary dyskinesia., PMID:39115449
Developmental dyslexia susceptibility genes DNAAF4, DCDC2, and NRSN1 are associated with brain function in fluently reading adolescents and young adults., PMID:38610086
Gene dosage of independent dynein arm motor preassembly factors influences cilia assembly in Chlamydomonas reinhardtii., PMID:38498551
A novel homozygous splice variant in DNAAF4 is associated with asthenozoospermia., PMID:37674365
Genetic and protein interaction studies between the ciliary dyslexia candidate genes DYX1C1 and DCDC2., PMID:37237337
Identification of a novel splice site mutation in the DNAAF4 gene of a Chinese patient with primary ciliary dyskinesia., PMID:37147940
Homozygous mutation in DNAAF4 causes primary ciliary dyskinesia in a Chinese family., PMID:36583018
Case Report: DNAAF4 Variants Cause Primary Ciliary Dyskinesia and Infertility in Two Han Chinese Families., PMID:35903363
Strongly Truncated Dnaaf4 Plays a Conserved Role in Drosophila Ciliary Dynein Assembly as Part of an R2TP-Like Co-Chaperone Complex With Dnaaf6., PMID:35873488
Defects in the cytoplasmic assembly of axonemal dynein arms cause morphological abnormalities and dysmotility in sperm cells leading to male infertility., PMID:33635866
ATP2C2 and DYX1C1 are putative modulators of dyslexia-related MMR., PMID:29201552
Chlamydomonas DYX1C1/PF23 is essential for axonemal assembly and proper morphology of inner dynein arms., PMID:28892495
An effective combination of whole-exome sequencing and runs of homozygosity for the diagnosis of primary ciliary dyskinesia in consanguineous families., PMID:28801648
X-linked primary ciliary dyskinesia due to mutations in the cytoplasmic axonemal dynein assembly factor PIH1D3., PMID:28176794
Association analysis of dyslexia candidate genes in a Dutch longitudinal sample., PMID:28074887
Mutations in PIH1D3 Cause X-Linked Primary Ciliary Dyskinesia with Outer and Inner Dynein Arm Defects., PMID:28041644
[Research advances in susceptible genes for developmental dyslexia in children]., PMID:27974128
Ciliary dyslexia candidate genes DYX1C1 and DCDC2 are regulated by Regulatory Factor X (RFX) transcription factors through X-box promoter motifs., PMID:27451412
Whole-Exome Sequencing and Targeted Copy Number Analysis in Primary Ciliary Dyskinesia., PMID:26139845
An assessment of gene-by-gene interactions as a tool to unfold missing heritability in dyslexia., PMID:25916574
The molecular genetics and neurobiology of developmental dyslexia as model of a complex phenotype., PMID:25078623
Unexpected genetic heterogeneity for primary ciliary dyskinesia in the Irish Traveller population., PMID:24824133
Association of SNPs of DYX1C1 with developmental dyslexia in an Indian population., PMID:24362368
Molecular genetics of dyslexia: an overview., PMID:24133036
DYX1C1 is required for axonemal dynein assembly and ciliary motility., PMID:23872636
The zebrafish orthologue of the dyslexia candidate gene DYX1C1 is essential for cilia growth and function., PMID:23650548
Knockdown of the candidate dyslexia susceptibility gene homolog dyx1c1 in rodents: effects on auditory processing, visual attention, and cortical and thalamic anatomy., PMID:23594585
DYX1C1 placed in a molecular context., PMID:23438632
A family-based association analysis and meta-analysis of the reading disabilities candidate gene DYX1C1., PMID:23341075
An assessment of gene-by-environment interactions in developmental dyslexia-related phenotypes., PMID:23176554
Genetic variant in KIAA0319, but not in DYX1C1, is associated with risk of dyslexia: an integrated meta-analysis., PMID:23065966
Molecular networks of DYX1C1 gene show connection to neuronal migration genes and cytoskeletal proteins., PMID:23036959
Association of the DYX1C1 dyslexia susceptibility gene with orthography in the Chinese population., PMID:23028439
Three dyslexia susceptibility genes, DYX1C1, DCDC2, and KIAA0319, affect temporo-parietal white matter structure., PMID:22683091
Exploring the transcriptome of ciliated cells using in silico dissection of human tissues., PMID:22558177
The aromatase gene CYP19A1: several genetic and functional lines of evidence supporting a role in reading, speech and language., PMID:22426781
The rs3743205 SNP is important for the regulation of the dyslexia candidate gene DYX1C1 by estrogen receptor β and DNA methylation., PMID:22383464
The dyslexia candidate gene DYX1C1 is a potential marker of poor survival in breast cancer., PMID:22375924
Neocortical disruption and behavioral impairments in rats following in utero RNAi of candidate dyslexia risk gene Kiaa0319., PMID:22326444
Evolutionary diversification of DYX1C1 transcripts via an HERV-H LTR integration event., PMID:22214596
Association of the rs3743205 variant of DYX1C1 with dyslexia in Chinese children., PMID:21599957
Genetic influences of cortical gray matter in language-related regions in healthy controls and schizophrenia., PMID:21507613
An examination of candidate gene SNPs for dyslexia in an Indian sample., PMID:21203818
[Neurobiology and neurogenetics of dyslexia]., PMID:21093706
The effects of embryonic knockdown of the candidate dyslexia susceptibility gene homologue Dyx1c1 on the distribution of GABAergic neurons in the cerebral cortex., PMID:21070838
Persistent spatial working memory deficits in rats following in utero RNAi of Dyx1c1., PMID:20977651
Analysis of dyslexia candidate genes in the Raine cohort representing the general Australian population., PMID:20846247
For research use only. Not for human or drug use.
