Catalog No.
YHE45601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly2-Lys80
Predicted molecular weight
21.73 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P45973
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Heterochromatin protein 1 homolog alpha, Chromobox protein homolog 5, HP1A, Antigen p25, HP1 alpha, CBX5
CBX5 loss drives Pl3Kδ inhibitor resistance in mantle cell lymphoma and propolis restores sensitivity by inducing CBX5-mediated ferroptosis., PMID:40466505
Understanding how genetically encoded tags and crowding agents affect phase separation by heterochromatin protein HP1α., PMID:40262618
A dynamic structural unit of phase-separated heterochromatin protein 1α as revealed by integrative structural analyses., PMID:40138713
Nuclear mechano-confinement induces geometry-dependent HP1α condensate alterations., PMID:40000755
Integrated bioinformatics investigation and experimental validation reveals the clinical and biological significance of chromobox family in breast cancer., PMID:39987187
CHAMP1 complex directs heterochromatin assembly and promotes homology-directed DNA repair., PMID:39962076
HP1 Promotes the Centromeric Localization of ATRX and Protects Cohesion by Interfering Wapl Activity in Mitosis., PMID:39862081
Nanosecond Molecular Motion in pHP1α Liquid-Liquid Phase Separation Captured by Solid-State NMR., PMID:39846510
Targeting the Epigenetic Regulator CBX5 Promotes Fibroblast Metabolic Reprogramming and Inhibits Lung Fibrosis., PMID:39642371
KMT5C leverages disorder to optimize cooperation with HP1 for heterochromatin retention., PMID:39562713
Werner syndrome RECQ helicase participates in and directs maintenance of the protein complexes of constitutive heterochromatin in proliferating human cells., PMID:39422615
Loss of miR-200c-3p promotes resistance to radiation therapy via the DNA repair pathway in prostate cancer., PMID:39414799
Structural mechanism of HP1⍺-dependent transcriptional repression and chromatin compaction., PMID:39383876
Heterochromatin protein 1 alpha (HP1α) undergoes a monomer to dimer transition that opens and compacts live cell genome architecture., PMID:39193905
Heterochromatin formation and remodeling by IRTKS condensates counteract cellular senescence., PMID:39192031
Inhibition of RUNX1 slows the progression of pulmonary hypertension by targeting CBX5., PMID:39151099
Potential Roles of Long Non-coding RNAs in the Pathogenesis of Periodontitis: Inflammation Response, Immune Infiltration, Collagen Fibers Synthesis, and Bone Remodeling., PMID:39108010
Defective Integrator activity shapes the transcriptome of patients with multiple sclerosis., PMID:39029934
Conformational diversity of human HP1α., PMID:38895997
Unveiling the role of HP1α-HDAC1-STAT1 axis as a therapeutic target for HP1α-positive intrahepatic cholangiocarcinoma., PMID:38812060
Bipartite binding interface recruiting HP1 to chromosomal passenger complex at inner centromeres., PMID:38781028
Epigenetic marks uniquely tune the material properties of HP1α condensates., PMID:38664966
Epigenetic regulators controlling osteogenic lineage commitment and bone formation., PMID:38341164
A CIC-related-epigenetic factors-based model associated with prediction, the tumor microenvironment and drug sensitivity in osteosarcoma., PMID:38225273
Prolonged Inhibition of the MEK1/2-ERK Signaling Axis Primes Interleukin-1 Beta Expression through Histone 3 Lysine 9 Demethylation in Murine Macrophages., PMID:37833877
An integrative bioinformatics investigation and experimental validation of chromobox family in diffuse large B-cell lymphoma., PMID:37430195
The local density of H3K9me3 dictates the stability of HP1α condensates-mediated genomic interactions., PMID:37116579
HP1α promotes the progression of prostate cancer., PMID:37014569
Comprehensive analysis reveals the value of the expression of chromobox family members for bladder urothelial carcinoma prognosis., PMID:36970607
CBX5 loss drives EGFR inhibitor resistance and results in therapeutically actionable vulnerabilities in lung cancer., PMID:36652476
Porphyromonas gingivalis Outer Membrane Vesicles Promote Apoptosis via msRNA-Regulated DNA Methylation in Periodontitis., PMID:36629433
Molecular interactions underlying the phase separation of HP1α: role of phosphorylation, ligand and nucleic acid binding., PMID:36537242
CBX Family Members in Two Major Subtypes of Renal Cell Carcinoma: A Comparative Bioinformatic Analysis., PMID:36292141
Expression and Prognostic Value of Chromobox Family Proteins in Esophageal Cancer., PMID:36140750
Bioinformatics and network-based approaches for determining pathways, signature molecules, and drug substances connected to genetic basis of schizophrenia etiology., PMID:35339428
Circ_0037866 Contributes to the Tumorigenesis of Renal Cell Carcinoma by Sequestering miR-384 to Elevate Chromobox 5 Expression., PMID:35249038
Prognostic Value and Therapeutic Potential of CBX Family Members in Ovarian Cancer., PMID:35155439
Discovery of Potent Peptidomimetic Antagonists for Heterochromatin Protein 1 Family Proteins., PMID:35036738
Systematic Variation of Both the Aromatic Cage and Dialkyllysine via GCE-SAR Reveal Mechanistic Insights in CBX5 Reader Protein Binding., PMID:35014255
MicroRNA-98-5p modulates cervical cancer progression via controlling PI3K/AKT pathway., PMID:34895048
Changes in the properties of membrane tethers in response to HP1α depletion in MCF7 cells., PMID:34872000
Prognostic and immune infiltrates for the Chromobox (CBX) protein family in human pancreatic adenocarcinoma., PMID:34790394
Targeting Cbx3/HP1γ Induces LEF-1 and IL-21R to Promote Tumor-Infiltrating CD8 T-Cell Persistence., PMID:34721405
Genetic Profile of Endotoxemia Reveals an Association With Thromboembolism and Stroke., PMID:34668383
Transcriptional control of CBX5 by the RNA binding proteins RBMX and RBMXL1 maintains chromatin state in myeloid leukemia., PMID:34458856
Interrogation of the dynamic properties of higher-order heterochromatin using CRISPR-dCas9., PMID:34428454
Comprehensive Analysis of the Expression and Prognosis Value of Chromobox Family Members in Clear Cell Renal Cell Carcinoma., PMID:34395271
[Role of Claudin-1 on diagnostic cut-off value and multiple tests in patients with papillary thyroid carcinoma]., PMID:34333937
LINC02381 contributes to cell proliferation and hinders cell apoptosis in glioma by transcriptionally enhancing CBX5., PMID:34274429
M33 condenses chromatin through nuclear body formation and methylation of both histone H3 lysine 9 and lysine 27., PMID:34274396
For research use only. Not for human or drug use.
