Catalog No.
YHK43201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu177-Phe589
Predicted molecular weight
47.78 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8IXI1
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Ras homolog gene family member T2, MIRO-2, ARHT2, hMiro-2, Mitochondrial Rho GTPase 2, C16orf39, RHOT2
Identification of susceptibility modules and characteristic genes to osteoarthritis by WGCNA., PMID:39297544
Proteomic characteristics reveal the signatures and the risks of T1 colorectal cancer metastasis to lymph nodes., PMID:37158593
Investigation of putative roles of smoking-associated salivary microbiome alterations on carcinogenesis by integrative in silico analysis., PMID:36587566
Integrating human brain proteomic data with genome-wide association study findings identifies novel brain proteins in substance use traits., PMID:35941285
MIROs and DRP1 drive mitochondrial-derived vesicle biogenesis and promote quality control., PMID:34873283
Loss of neuronal Miro1 disrupts mitophagy and induces hyperactivation of the integrated stress response., PMID:34152608
Coordination of mitochondrial and cellular dynamics by the actin-based motor Myo19., PMID:34013964
Insight into human Miro1/2 domain organization based on the structure of its N-terminal GTPase., PMID:33132189
Age-Dependent Assessment of Genes Involved in Cellular Senescence, Telomere, and Mitochondrial Pathways in Human Lung Tissue of Smokers, COPD, and IPF: Associations With SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 Axis., PMID:33013423
The role of RHOT1 and RHOT2 genetic variation on Parkinson disease risk and onset., PMID:32948353
Age-dependent assessment of genes involved in cellular senescence, telomere and mitochondrial pathways in human lung tissue of smokers, COPD and IPF: Associations with SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 axis., PMID:32702724
Age-dependent assessment of genes involved in cellular senescence, telomere and mitochondrial pathways in human lung tissue of smokers, COPD and IPF: Associations with SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 axis., PMID:32587985
Peroxisomal fission is modulated by the mitochondrial Rho-GTPases, Miro1 and Miro2., PMID:31894645
Miro clusters regulate ER-mitochondria contact sites and link cristae organization to the mitochondrial transport machinery., PMID:31562315
Miro2 Regulates Inter-Mitochondrial Communication in the Heart and Protects Against TAC-Induced Cardiac Dysfunction., PMID:31455181
Preserving Mitochondrial Structure and Motility Promotes Recovery of White Matter After Ischemia., PMID:31152363
Myc Regulation of a Mitochondrial Trafficking Network Mediates Tumor Cell Invasion and Metastasis., PMID:31061095
Miro-dependent mitochondrial pool of CENP-F and its farnesylated C-terminal domain are dispensable for normal development in mice., PMID:30856164
Mitochondrial transport proteins RHOT1 and RHOT2 serve as docking sites for PRKN-mediated mitophagy., PMID:30806158
Epigenetic signature: implications for mitochondrial quality control in human aging., PMID:30787202
Miro proteins prime mitochondria for Parkin translocation and mitophagy., PMID:30504269
Human Miro Proteins Act as NTP Hydrolases through a Novel, Non-Canonical Catalytic Mechanism., PMID:30513825
GBF1 and Arf1 interact with Miro and regulate mitochondrial positioning within cells., PMID:30459446
Identification of Miro1 and Miro2 as mitochondrial receptors for myosin XIX., PMID:30111583
Proteomics and bioinformatics analyses identify novel cellular roles outside mitochondrial function for human miro GTPases., PMID:29943371
Genomic convergence of locus-based GWAS meta-analysis identifies AXIN1 as a novel Parkinson's gene., PMID:29923028
NOS3 Inhibition Confers Post-Ischemic Protection to Young and Aging White Matter Integrity by Conserving Mitochondrial Dynamics and Miro-2 Levels., PMID:29891729
Miro proteins coordinate microtubule- and actin-dependent mitochondrial transport and distribution., PMID:29311115
A PGAM5-KEAP1-Nrf2 complex is required for stress-induced mitochondrial retrograde trafficking., PMID:28839075
TNFα decreases mitochondrial movement in human airway smooth muscle., PMID:28473328
A neuronal network of mitochondrial dynamics regulates metastasis., PMID:27991488
Loss of Dendritic Complexity Precedes Neurodegeneration in a Mouse Model with Disrupted Mitochondrial Distribution in Mature Dendrites., PMID:27705781
Structural insights into Parkin substrate lysine targeting from minimal Miro substrates., PMID:27605430
Characterization of the three zebrafish orthologs of the mitochondrial GTPase Miro/Rhot., PMID:26482085
Mitotic redistribution of the mitochondrial network by Miro and Cenp-F., PMID:26259702
Neuroprotective effects of 5-(4-hydroxy-3-dimethoxybenzylidene)-thiazolidinone in MPTP induced Parkinsonism model in mice., PMID:25680233
Mitochondrial trafficking in neurons and the role of the Miro family of GTPase proteins., PMID:24256248
The Eutherian Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro and Trak2., PMID:22569362
PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility., PMID:22078885
Mitofusin 2 is necessary for transport of axonal mitochondria and interacts with the Miro/Milton complex., PMID:20335458
HUMMR, a hypoxia- and HIF-1alpha-inducible protein, alters mitochondrial distribution and transport., PMID:19528298
Pink1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking., PMID:19152501
Bidirectional Ca2+-dependent control of mitochondrial dynamics by the Miro GTPase., PMID:19098100
The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking., PMID:16630562
Cloning and characterization of the mouse Arht2 gene which encodes a putative atypical GTPase., PMID:15218247
Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis., PMID:12482879