Catalog No.
YHK41701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gln49-Ser463
Predicted molecular weight
48.31 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9Y230
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
48 kDa TATA box-binding protein-interacting protein, RuvB-like 2, INO80 complex subunit J, RUVBL2, TAP54-beta, Reptin 52, TIP60-associated protein 54-beta, TIP48, TIP49B, 51 kDa erythrocyte cytosolic protein, 48 kDa TBP-interacting protein, Repressing pontin 52, INO80J, TIP49b, ECP-51
Aedes aegypti encodes an ATPase-active RUVBL1/2 complex., PMID:40505928
Detection of Anti-RuvBL1/2 Autoantibodies by Targeted Liquid Chromatography-Tandem Mass Spectrometry., PMID:40498123
The P-loop NTPase RUVBL2 is a conserved clock component across eukaryotes., PMID:40140583
Genome-wide CRISPR activation screen identifies ARL11 as a sensitivity determinant of PARP inhibitor therapy., PMID:40123001
Study on DNA Damage Gene in Spermatogonial Stem Cells from Idiopathic Nonobstructive Azoospermia: A Bioinformatics Investigation Based on scRNA-seq Data., PMID:40101697
The structure of the R2T complex reveals a different architecture from the related HSP90 cochaperone R2TP., PMID:40015274
Identification of RUVBL2 as a novel biomarker to predict the prognosis and drug sensitivity in multiple myeloma based on ferroptosis genes., PMID:39985176
Identification of critical genes and drug repurposing targets in entorhinal cortex of Alzheimer's disease., PMID:39928227
In silico protein structural analysis of PRMT5 and RUVBL1 mutations arising in human cancers., PMID:39874873
A large-scale proteomics resource of circulating extracellular vesicles for biomarker discovery in pancreatic cancer., PMID:39693144
RuvBL1/2 reduce toxic dipeptide repeat protein burden in multiple models of C9orf72-ALS/FTD., PMID:39638345
Knockdown of RUVBL2 improves hnRNPA2/B1-stress granules dynamics to inhibit perioperative neurocognitive disorders in aged mild cognitive impairment rats., PMID:39610020
Cotranslational molecular condensation of cochaperones and assembly factors facilitates axonemal dynein biogenesis., PMID:39541357
The HSP90/R2TP Quaternary Chaperone Scaffolds Assembly of the TSC Complex., PMID:39490680
Paraventricular hypothalamic RUVBL2 neurons suppress appetite by enhancing excitatory synaptic transmission in distinct neurocircuits., PMID:39414808
Molecular Signatures of CB-6644 Inhibition of the RUVBL1/2 Complex in Multiple Myeloma., PMID:39201707
Structure of the human TIP60 complex., PMID:39154037
AP3B1 facilitates PDIA3/ERP57 function to regulate rabies virus glycoprotein selective degradation and viral entry., PMID:39128851
An integrated structural model of the DNA damage-responsive H3K4me3 binding WDR76:SPIN1 complex with the nucleosome., PMID:39116123
Maturation and Assembly of mTOR Complexes by the HSP90-R2TP-TTT Chaperone System: Molecular Insights and Mechanisms., PMID:38963496
Molecular insights into type I interferon suppression and enhanced pathogenicity by species B human adenoviruses B7 and B14., PMID:38940561
RUVBL1/2 Blockade Targets YTHDF1 Activity to Suppress m6A-Dependent Oncogenic Translation and Colorectal Tumorigenesis., PMID:38900944
Targeting MYC effector functions in pancreatic cancer by inhibiting the ATPase RUVBL1/2., PMID:38821858
A novel LINC02321 promotes cell proliferation and decreases cisplatin sensitivity in bladder cancer by regulating RUVBL2., PMID:38677015
RUVBL1 ubiquitination by DTL promotes RUVBL1/2-β-catenin-mediated transcriptional regulation of NHEJ pathway and enhances radiation resistance in breast cancer., PMID:38609375
In silico characterization and identification of compound heterozygous variants in H/ACA Ribonucleoprotein Assembly Factor (SHQ1) from Indian population., PMID:38482315
LOXL2-mediated chromatin compaction is required to maintain the oncogenic properties of triple-negative breast cancer cells., PMID:38451841
DPCD is a regulator of R2TP in ciliogenesis initiation through Akt signaling., PMID:38306274
The multi-faceted roles of R2TP complex span across regulation of gene expression, translation, and protein functional assembly., PMID:38192347
Adenovirus E1A binding to DCAF10 targets proteasomal degradation of RUVBL1/2 AAA+ ATPases required for quaternary assembly of multiprotein machines, innate immunity, and responses to metabolic stress., PMID:37962355
Extract2Chip-Bypassing Protein Purification in Drug Discovery Using Surface Plasmon Resonance., PMID:37887106
Mycobacterium tuberculosis suppresses host DNA repair to boost its intracellular survival., PMID:37848028
Suramin action in African trypanosomes involves a RuvB-like DNA helicase., PMID:37757728
Plasma cells in human pancreatic ductal adenocarcinoma secrete antibodies against self-antigens., PMID:37751306
Identification and characterization of RuvBL DNA helicase genes for tolerance against abiotic stresses in bread wheat (Triticum aestivum L.) and related species., PMID:37498392
Bioinformatics analysis and identification of hub genes of neutrophils in Kawasaki disease: a pivotal study., PMID:37394620
A Large-Scale Proteomics Resource of Circulating Extracellular Vesicles for Biomarker Discovery in Pancreatic Cancer., PMID:36993200
LINKIN-associated proteins necessary for tissue integrity during collective cell migration., PMID:36798316
RUVBL proteins are involved in plant gametophyte development., PMID:36752686
Cell cycle protein BORA is associated with colorectal cancer progression by AURORA-PLK1 cascades: a bioinformatics analysis., PMID:36538275
EP400NL is involved in PD-L1 gene activation by forming a transcriptional coactivator complex., PMID:36328277
The transcriptional coactivator RUVBL2 regulates Pol II clustering with diverse transcription factors., PMID:36171202
Deciphering cellular and molecular determinants of human DPCD protein in complex with RUVBL1/RUVBL2 AAA-ATPases., PMID:35901867
The landscape of isoform switches in sepsis: a multicenter cohort study., PMID:35715539
Unconventional tonicity-regulated nuclear trafficking of NFAT5 mediated by KPNB1, XPOT and RUVBL2., PMID:35635291
Regionally defined proteomic profiles of human cerebral tissue and organoids reveal conserved molecular modules of neurodevelopment., PMID:35613588
Discovery of small-molecule inhibitors of RUVBL1/2 ATPase., PMID:35364523
Differential proteomic analysis demonstrates follicle fluid participate immune reaction and protein translation in yak., PMID:35031034
CryoEM of RUVBL1-RUVBL2-ZNHIT2, a complex that interacts with pre-mRNA-processing-splicing factor 8., PMID:34951455
Structure of the Human TELO2-TTI1-TTI2 Complex., PMID:34838521