Catalog No.
YHK41501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly660-Cys713
Predicted molecular weight
34.64 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q5SWA1
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PPP1R15B, Protein phosphatase 1 regulatory subunit 15B
Based exploration of the diagnostic value of oxidative stress-related key genes in chronic obstructive pulmonary disease., PMID:40214820
Translation Complex Profile Sequencing Allows Discrimination of Leaky Scanning and Reinitiation in Upstream Open Reading Frame-controlled Translation., PMID:39486574
Super enhancer acquisition drives expression of oncogenic PPP1R15B that regulates protein homeostasis in multiple myeloma., PMID:39122682
Substrate recruitment via eIF2γ enhances catalytic efficiency of a holophosphatase that terminates the integrated stress response., PMID:38547060
Recruitment of trimeric eIF2 by phosphatase non-catalytic subunit PPP1R15B., PMID:38159565
The PPP1R15 Family of eIF2-alpha Phosphatase Targeting Subunits (GADD34 and CReP)., PMID:38139150
mir-98-5p regulates gluconeogenesis and lipogenesis by targeting PPP1R15B in hepatocytes., PMID:36917438
An Overview of Methods for Detecting eIF2α Phosphorylation and the Integrated Stress Response., PMID:35171470
Substrate recognition determinants of human eIF2α phosphatases., PMID:34847777
Comprehensive analysis of DNA methylation and gene expression profiles in gestational diabetes mellitus., PMID:34190178
Circulatory miR-98-5p levels are deregulated during diabetes and it inhibits proliferation and promotes apoptosis by targeting PPP1R15B in keratinocytes., PMID:31615341
PromISR-6, a Guanabenz Analogue, Improves Cellular Survival in an Experimental Model of Huntington's Disease., PMID:31313908
PP1 Phosphatase Complexes: Undruggable No Longer., PMID:30142342
Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B., PMID:30057111
Preemptive Activation of the Integrated Stress Response Protects Mice From Diet-Induced Obesity and Insulin Resistance by Fibroblast Growth Factor 21 Induction., PMID:29698569
A Sephin1-insensitive tripartite holophosphatase dephosphorylates translation initiation factor 2α., PMID:29618508
AP-SWATH Reveals Direct Involvement of VCP/p97 in Integrated Stress Response Signaling Through Facilitating CReP/PPP1R15B Degradation., PMID:29599191
Systematic Selection of Reference Genes for the Normalization of Circulating RNA Transcripts in Pregnant Women Based on RNA-Seq Data., PMID:28777335
Infantile Cirrhosis, Growth Impairment, and Neurodevelopmental Anomalies Associated with Deficiency of PPP1R15B., PMID:27640355
Complementary Roles of GADD34- and CReP-Containing Eukaryotic Initiation Factor 2α Phosphatases during the Unfolded Protein Response., PMID:27161320
An inhibitor of HIV-1 protease modulates constitutive eIF2α dephosphorylation to trigger a specific integrated stress response., PMID:26715744
Ribosome Reinitiation Directs Gene-specific Translation and Regulates the Integrated Stress Response., PMID:26446796
Constitutive role of GADD34 and CReP in cancellation of phospho-eIF2α-dependent translational attenuation and insulin biosynthesis in pancreatic β cells., PMID:26314560
Homozygous mutation in the eukaryotic translation initiation factor 2alpha phosphatase gene, PPP1R15B, is associated with severe microcephaly, short stature and intellectual disability., PMID:26307080
A Missense Mutation in PPP1R15B Causes a Syndrome Including Diabetes, Short Stature, and Microcephaly., PMID:26159176
IRE1α-Dependent Decay of CReP/Ppp1r15b mRNA Increases Eukaryotic Initiation Factor 2α Phosphorylation and Suppresses Protein Synthesis., PMID:26031337
Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit., PMID:25859045
G-actin provides substrate-specificity to eukaryotic initiation factor 2α holophosphatases., PMID:25774600
Actin dynamics tune the integrated stress response by regulating eukaryotic initiation factor 2α dephosphorylation., PMID:25774599
Translation of 5' leaders is pervasive in genes resistant to eIF2 repression., PMID:25621764
Coordinate regulation of eIF2α phosphorylation by PPP1R15 and GCN2 is required during Drosophila development., PMID:23418347
Protein phosphatase 1, regulatory subunit 15B is a survival factor for ERα-positive breast cancer., PMID:23169272
A subunit of eukaryotic translation initiation factor 2α-phosphatase (CreP/PPP1R15B) regulates membrane traffic., PMID:22915583
Phosphoproteins in stress-induced disease., PMID:22340719
Adaptive basal phosphorylation of eIF2α is responsible for resistance to cellular stress-induced cell death in Pten-null hepatocytes., PMID:22009178
Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis., PMID:21385720
Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2alpha) dephosphorylation in mammalian development., PMID:19181853
Network inference algorithms elucidate Nrf2 regulation of mouse lung oxidative stress., PMID:18769717
Expression and functional activity of pro-oxidants and antioxidants in murine heart exposed to acute hypobaric hypoxia., PMID:17825300
A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress., PMID:15705855
Inhibition of a constitutive translation initiation factor 2alpha phosphatase, CReP, promotes survival of stressed cells., PMID:14638860