Catalog No.
DHK29301
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Human
Isotype
IgG
Clonality
Monoclonal
Target
IL-15 receptor subunit alpha, sIL-15R-alpha, IL-15RA, CD215, sIL-15 receptor subunit alpha, Interleukin-15 receptor subunit alpha, IL-15R-alpha, sIL-15RA, IL15RA, IL-2R subunit beta, Interleukin-15 receptor subunit beta, IL2RB, IL-2 receptor subunit beta, CD122, High affinity IL-2 receptor subunit beta, p75, Interleukin-2 receptor subunit beta, IL-2RB, p70-75, IL15RB, p64, Interleukin-2 receptor subunit gamma, gammaC, IL-2 receptor subunit gamma, CD132, IL-2R subunit gamma, IL-2RG, IL2RG, Cytokine receptor common subunit gamma
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q13261 & P14784 & P31785
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
DR50402
Clone ID
DR50402
Comparative Efficacy of Interleukin-7 and -15 Blockade in Alleviating Experimental Chronic Uveitis and Suppressing Pathogenic Memory CD4+ T Cells., PMID:40323267
[Biological activity and antitumor effect of long-acting recombinant human interleukin-2 drug]., PMID:40219553
CLEC12A-directed immunocytokine with target cell-restricted IL-15 activity for treatment of acute myeloid leukemia., PMID:40213559
Functional insights of an uncommon hypomorphic variant in IL2RG as a monogenic cause of CVID-like disease with antibody deficiency and T CD4 lymphopenia., PMID:40170851
Orchestrating T and NK cells for tumor immunotherapy via NKG2A-targeted delivery of a de novo designed IL-2Rβγ agonist., PMID:40170468
Selective activation of interleukin-2/interleukin-15 receptor signaling in tumor microenvironment using paired bispecific antibodies., PMID:40132909
Humanized Mouse Model of Graft-Versus-Host Disease Utilizing Nonirradiated NOD-scid-IL-2Rγnull Mice., PMID:40100599
CD94-driven in vitro expansion of highly functional adaptive NKG2C+ NKG2A- CD57+ NK cells from CMV+ healthy donors., PMID:39958331
NK cell depletion in bispecific antibody therapy is associated with lack of HIV control after ART interruption., PMID:39953264
Nanrilkefusp alfa (SOT101), an IL-15 receptor βγ superagonist, as a single agent or with anti-PD-1 in patients with advanced cancers., PMID:39933529
[Exploration of CCL11 and sTNFR2 as potential biomarkers for the efficacy of lymphocyte immunotherapy in women with unexplained recurrent spontaneous abortion]., PMID:39863550
A New Antibody-Cytokine Construct Targeting Natural Killer Cells: An Immunotherapeutic Approach to Chronic Lymphocytic Leukemia., PMID:39858511
Plant-derived Pembrolizumab in conjugation with IL-15Rα-IL-15 complex shows effective anti-tumor activity., PMID:39808627
Induced pluripotent stem-cell-derived CD19-directed chimeric antigen receptor natural killer cells in B-cell lymphoma: a phase 1, first-in-human trial., PMID:39798981
In utero human cytomegalovirus infection expands NK-like FcγRIII+CD8+ T cells that mediate Fc antibody functions., PMID:39531313
Improved antitumor effectiveness of oncolytic HSV-1 viruses engineered with IL-15/IL-15Rα complex combined with oncolytic HSV-1-aPD1 targets colon cancer., PMID:39389985
Recurrent pancreatic cancer treated with N-803 and PD-L1 t-haNK followed by an EGFR-targeted nanocell drug conjugate., PMID:39373598
Single-cell RNA sequencing reveals anti-tumor potency of CD56+ NK cells and CD8+ T cells in humanized mice via PD-1 and TIGIT co-targeting., PMID:39318093
Elevated IL-15 levels in systemic lupus erythematosus: potential pathogenesis insight and therapeutic target., PMID:39217881
Biological variability of human intraepithelial lymphocytes throughout the human gastrointestinal tract in health and coeliac disease., PMID:39210517
CD122 is an activation marker ensuring proper proliferation of T cells in teleost., PMID:39153581
Enhanced IL-15-mediated NK cell activation and proliferation by an ADAM17 function-blocking antibody involves CD16A, CD137, and accessory cells., PMID:39053944
A "Prime and Expand" strategy using the multifunctional fusion proteins to generate memory-like NK cells for cell therapy., PMID:38960949
Chemokines and Cytokines in Immunotherapy of Melanoma and Other Tumors: From Biomarkers to Therapeutic Targets., PMID:38928238
Payload-delivering engineered γδ T cells display enhanced cytotoxicity, persistence, and efficacy in preclinical models of osteosarcoma., PMID:38809963
IL-15/IL-15Rα-Fc-Fusion Protein XmAb24306 Potentiates Activity of CD3 Bispecific Antibodies through Enhancing T-Cell Expansion., PMID:38739434
Choosing T-cell sources determines CAR-T cell activity in neuroblastoma., PMID:38601159
GT-00AxIL15, a Novel Tumor-Targeted IL-15-Based Immunocytokine for the Treatment of TA-MUC1-Positive Solid Tumors: Preclinical In Vitro and In Vivo Pharmacodynamics and Biodistribution Studies., PMID:38338686
Dual Targeting of Glioblastoma Cells with Bispecific Killer Cell Engagers Directed to EGFR and ErbB2 (HER2) Facilitates Effective Elimination by NKG2D-CAR-Engineered NK Cells., PMID:38334638
Pharmacokinetics, pharmacodynamics, and toxicity of a PD-1-targeted IL-15 in cynomolgus monkeys., PMID:38315680
SHIV-C109p5 NHP induces rapid disease progression in elderly macaques with extensive GI viral replication., PMID:38299866
The immune enhancing effect of antimicrobial peptide LLv on broilers chickens., PMID:38035471
NKG2D receptor signaling shapes T cell thymic education., PMID:37949818
[The Change in Subpopulation and Function of Natural Killer Cells in Adult Patients with Infectious Mononucleosis Related Liver Injury]., PMID:37551501
An optimized cultivation method for future in vivo application of γδ T cells., PMID:37539052
[Construction of NKG2D CAR-NK92 cells and its killing effect on multiple myeloma cells]., PMID:37403715
Blockade of CD122 on memory T cells in the skin suppresses sclerodermatous graft-versus-host disease., PMID:36966029
Blocking common γ chain cytokine signaling ameliorates T cell-mediated pathogenesis in disease models., PMID:36630481
Influenza vaccination reveals sex dimorphic imprints of prior mild COVID-19., PMID:36599369
Soluble factors from TLR4- or TCR-activated cells contribute to stability of the resting phenotype and increase the expression of CXCR4 of human memory CD4 T cells., PMID:36539634
BCL11B depletion induces the development of highly cytotoxic innate T cells out of IL-15 stimulated peripheral blood αβ CD8+ T cells., PMID:36507091
Quadruple gene-engineered natural killer cells enable multi-antigen targeting for durable antitumor activity against multiple myeloma., PMID:36446823
Improving the ex vivo expansion of human tumor-reactive CD8 + T cells by targeting toll-like receptors., PMID:36394017
SOT101 induces NK cell cytotoxicity and potentiates antibody-dependent cell cytotoxicity and anti-tumor activity., PMID:36300122
PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program., PMID:36171288
Strategies to evaluate potential effector function of glycan variants: a case study of ordesekimab (AMG 714 or PRV-015)., PMID:36083248
Effective innate immune response in natural HIV-1 controllers. Can mimicking lead to novel preventive and cure strategies against HIV-1?, PMID:35938465
Imprint of Initial Education and Loss of Ly49C/I in Activated Natural Killer Cells of TAP1-KO and C57BL/6 Wildtype Mice., PMID:35911713
Improving NK cell function in multiple myeloma with NKTR-255, a novel polymer-conjugated human IL-15., PMID:35882498
CD4dim CD8bright T Cells Home to the Brain and Mediate HIV Neuroinvasion., PMID:35852355
For research use only. Not for human or drug use.
