Catalog No.
FHG70410
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Conjugation
Unconjugated
Target
CD36, 85 kDa lysosomal membrane sialoglycoprotein, CD36 antigen-like 2, CD36L2, SCARB2, Lysosome membrane protein 2, LIMP II, Scavenger receptor class B member 2, Lysosome membrane protein II, LIMPII, LIMP2, LGP85
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q14108
Applications
Blocking, ELISA, FCM, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.09% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA0777
Plasminogen deficiency reduces disease severity and immune responses in enterovirus A71-infected mice., PMID:40377310
Broadly therapeutic antibody provides cross-serotype protection against enteroviruses via Fc effector functions and by mimicking SCARB2., PMID:39424982
Antibody signatures in hospitalized hand, foot and mouth disease patients with acute enterovirus A71 infection., PMID:37262073
Dual blockages of a broad and potent neutralizing IgM antibody targeting GH loop of EV-As., PMID:36726218
Molecular mechanism of antibody neutralization of coxsackievirus A16., PMID:36543790
Chemokine PF4 Inhibits EV71 and CA16 Infections at the Entry Stage., PMID:35579435
TAK - 021, an inactivated Enterovirus 71 vaccine candidate, provides cross-protection against heterologous sub-genogroups in human scavenger receptor B2 transgenic mice., PMID:35501179
Molecular Docking of SP40 Peptide towards Cellular Receptors for Enterovirus 71 (EV-A71)., PMID:34770987
Engineering a novel IgG-like bispecific antibody against enterovirus A71., PMID:34095549
A practical method for evaluating the in vivo efficacy of EVA-71 vaccine using a hSCARB2 knock-in mouse model., PMID:34044752
Dominant atopy risk mutations identified by mouse forward genetic analysis., PMID:32810290
Development of an Enterovirus 71 Vaccine Efficacy Test Using Human Scavenger Receptor B2 Transgenic Mice., PMID:31896594
A CpG-adjuvanted intranasal enterovirus 71 vaccine elicits mucosal and systemic immune responses and protects human SCARB2-transgenic mice against lethal challenge., PMID:30013088
Neutralization Mechanisms of Two Highly Potent Antibodies against Human Enterovirus 71., PMID:29970466
Visualization and Measurement of Multiple Components of the Autophagy Flux., PMID:29936691
VP1 Amino Acid Residue 145 of Enterovirus 71 Is a Key Residue for Its Receptor Attachment and Resistance to Neutralizing Antibody during Cynomolgus Monkey Infection., PMID:29848582
Prokaryotic expression and identification of scavenger receptor B2., PMID:29521103
The binding of a monoclonal antibody to the apical region of SCARB2 blocks EV71 infection., PMID:28447294
Effective in vivo therapeutic IgG antibody against VP3 of enterovirus 71 with receptor-competing activity., PMID:28422137
Update on systemic vasculitides., PMID:28377447
Development of a full-length cDNA-derived enterovirus A71 vaccine candidate using reverse genetics technology., PMID:27387826
A safe and sensitive enterovirus A71 infection model based on human SCARB2 knock-in mice., PMID:27102822
Structural Basis for Recognition of Human Enterovirus 71 by a Bivalent Broadly Neutralizing Monoclonal Antibody., PMID:26938634
The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate., PMID:26430888
Single Neutralizing Monoclonal Antibodies Targeting the VP1 GH Loop of Enterovirus 71 Inhibit both Virus Attachment and Internalization during Viral Entry., PMID:26401034
Increased expression of lysosome membrane protein 2 in glomeruli of patients with idiopathic membranous nephropathy., PMID:26304790
Mannose 6-phosphate-independent Lysosomal Sorting of LIMP-2., PMID:26219725
SCARB2/LIMP-2 Regulates IFN Production of Plasmacytoid Dendritic Cells by Mediating Endosomal Translocation of TLR9 and Nuclear Translocation of IRF7., PMID:25862818
Action myoclonus-renal failure syndrome: diagnostic applications of activity-based probes and lipid analysis., PMID:24212238
Heat shock protein 90: role in enterovirus 71 entry and assembly and potential target for therapy., PMID:24098578
Protective efficacy of VP1-specific neutralizing antibody associated with a reduction of viral load and pro-inflammatory cytokines in human SCARB2-transgenic mice., PMID:23936115
Progressive myoclonus epilepsy: extraneuronal brown pigment deposition and system neurodegeneration in the brains of Japanese patients with novel SCARB2 mutations., PMID:23659519
Abnormal Processing of Autophagosomes in Transformed B Lymphocytes from SCARB2-Deficient Subjects., PMID:23515316
Glycine dimerization motif in the N-terminal transmembrane domain of the high density lipoprotein receptor SR-BI required for normal receptor oligomerization and lipid transport., PMID:21454587
Tubular proteinuria in mice and humans lacking the intrinsic lysosomal protein SCARB2/Limp-2., PMID:21429972
Distribution of smooth muscle cells and macrophages expressing scavenger receptor BI/II in atherosclerosis., PMID:20032583
Scavenger receptor B2 is a cellular receptor for enterovirus 71., PMID:19543282
Scavenger receptor BI and BII expression levels modulate hepatitis C virus infectivity., PMID:17215280
DNA vaccination can break immunological tolerance to PrP in wild-type mice and attenuates prion disease after intracerebral challenge., PMID:17005675
DNA vaccines expressing B and T cell epitopes can protect mice from FMDV infection in the absence of specific humoral responses., PMID:16563575
Molecular characterization of rabbit scavenger receptor class B types I and II: portal to central vein gradient of expression in the liver., PMID:14595001
A role for the lysosomal membrane protein LGP85 in the biogenesis and maintenance of endosomal and lysosomal morphology., PMID:12356916
Human retinal pigment epithelial cells express scavenger receptors BI and BII., PMID:11944916
CD4(+) T cells induced by a DNA vaccine: immunological consequences of epitope-specific lysosomal targeting., PMID:11581410
Differentiation-dependent expression and localization of the class B type I scavenger receptor in intestine., PMID:11369797
Limited and selective localization of the lysosomal membrane glycoproteins LGP85 and LGP96 in rat osteoclasts., PMID:10219623
Microtubule reorganization and lysosome redistribution by a viral v-src oncogene, in mouse Balb/3T3 cells expressing human EGF receptor., PMID:7720100
Cycling of an 85-kDa lysosomal membrane glycoprotein between the cell surface and lysosomes in cultured rat hepatocytes., PMID:7852289
Lysosomal targeting of Limp II membrane glycoprotein requires a novel Leu-Ile motif at a particular position in its cytoplasmic tail., PMID:8106503
For research use only. Not for human or drug use.
