InVivoMAb Anti-Human GFRAL (Iv0105)

Catalog No.

VHH55901

Species reactivity

Human

Host species

Human

Isotype

IgG1

Clonality

Monoclonal

Target

C6orf144, GDNF family receptor alpha-like, GFRAL

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q6UXV0

Applications

ELISA, Neutralization

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

Iv0105

Molecular and Functional Significance of Growth Differentiation Factor-15: A Review on Cardiovascular-Kidney-Metabolic Biomarker., PMID:39781722

GB18-06, a nanobody targeting GDF15, effectively alleviates weight loss and restores physical function in cachexia models., PMID:39400041

Acute Activation of GFRAL in the Area Postrema Contributes to Glucose Regulation Independent of Weight., PMID:38064571

Growth differentiation factor-15 is an IFN-γ regulated mediator of infection-induced weight loss and the hepatic FGF21 response., PMID:38013040

Creation of a Peptide Antagonist of the GFRAL-RET Receptor Complex for the Treatment of GDF15-Induced Malaise., PMID:37506293

GDNF family receptor alpha-like antagonist antibody alleviates chemotherapy-induced cachexia in melanoma-bearing mice., PMID:37017344

GDF15 Is an Eribulin Response Biomarker also Required for Survival of DTP Breast Cancer Cells., PMID:35626166

Body weight regulation via MT1-MMP-mediated cleavage of GFRAL., PMID:35177851

Fc-GDF15 glyco-engineering and receptor binding affinity optimization for body weight regulation., PMID:33903632

Treatment with GDF15, a TGFβ superfamily protein, induces protective effect on retinal ganglion cells., PMID:33157126

Growth differentiation factor 15 (GDF-15) is a novel orexigen in fish., PMID:31991159

ARRB1 inhibits non-alcoholic steatohepatitis progression by promoting GDF15 maturation., PMID:31857195

Prostate cancer promotes a vicious cycle of bone metastasis progression through inducing osteocytes to secrete GDF15 that stimulates prostate cancer growth and invasion., PMID:30755731

The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL., PMID:28846098

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InVivoMAb Anti-Human GFRAL (Iv0105).pdf