Catalog No.
FHA19610
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Conjugation
Unconjugated
Target
CPER, CLDN4, Williams-Beuren syndrome chromosomal region 8 protein, CPE-R, CPE-receptor, WBSCR8, Claudin-4, Clostridium perfringens enterotoxin receptor, CPETR1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
O14493
Applications
ELISA, FCM, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.09% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA0509
p38 MAPK-mediated upregulation of claudin-3 and claudin-4 by gemcitabine contributes to chemoresistance in ovarian cancer., PMID:40403836
Robust immune responses to intranasal vaccine targeting Bordetella pertussis antigens to claudin-4 on mucosal microfold cells., PMID:40220802
Claudin 1, 4, 6 and 18 isoform 2 as targets for the treatment of cancer (Review)., PMID:39301632
Comparison of Claudin-4, BerEP4, Carcinoembryonic Antigen and MOC31 in Serous Fluids Metastases Demonstrate High Sensitivity of Claudin-4 at Low Cellularity., PMID:39138853
Structural and biophysical insights into targeting of claudin-4 by a synthetic antibody fragment., PMID:38886509
Claudin-4: A New Molecular Target for Epithelial Cancer Therapy., PMID:36982569
Expression of Claudin-4 and D2-40 and their significance in prostatic adenocarcinoma., PMID:38384059
Claudins and Gastric Cancer: An Overview., PMID:35053454
Innovative and Highly Sensitive Detection of Clostridium perfringens Enterotoxin Based on Receptor Interaction and Monoclonal Antibodies., PMID:33917845
HMGB1 enhances epithelial permeability via p63/TGF-β signaling in lung and terminal bronchial epithelial cells., PMID:32857676
Targeting claudin-4 enhances chemosensitivity in breast cancer., PMID:32086991
BACH1 Promotes Pancreatic Cancer Metastasis by Repressing Epithelial Genes and Enhancing Epithelial-Mesenchymal Transition., PMID:31919242
Targeting claudin-4 enhances chemosensitivity of pancreatic ductal carcinomas., PMID:31498559
Targeting claudin-4 enhances CDDP-chemosensitivity in gastric cancer., PMID:31040910
Anti-claudin-4 extracellular domain antibody enhances the antitumoral effects of chemotherapeutic and antibody drugs in colorectal cancer., PMID:30647838
Analysis of the effect of promoter type and skin pretreatment on antigen expression and antibody response after gene gun-based immunization., PMID:29856790
Acanthamoeba (T4) trophozoites cross the MDCK epithelium without cell damage but increase paracellular permeability and transepithelial resistance by modifying tight junction composition., PMID:29097064
Surfaceome profiling enables isolation of cancer-specific exosomal cargo in liquid biopsies from pancreatic cancer patients., PMID:29045505
Impaired Barrier Function and Autoantibody Generation in Malnutrition Enteropathy in Zambia., PMID:28750860
Claudin-targeted drug development using anti-claudin monoclonal antibodies to treat hepatitis and cancer., PMID:28415141
Efficacy and safety evaluation of claudin-4-targeted antitumor therapy using a human and mouse cross-reactive monoclonal antibody., PMID:27713828
Claudin-1 Protein Expression Is a Good Prognostic Factor in Non-Small Cell Lung Cancer, but only in Squamous Cell Carcinoma Cases., PMID:27687058
Tight junction protein claudin 4 in gastric carcinoma and its relation to lymphangiogenic activity., PMID:26526513
Prognostic Significance of Lymphatic Vessel Density Detected by D2-40 and Its Relation to Claudin-4 Expression in Prostatic Adenocarcinoma., PMID:26464161
Pro-chemotherapeutic effects of antibody against extracellular domain of claudin-4 in bladder cancer., PMID:26342407
Claudin-1 Binder Enhances Epidermal Permeability in a Human Keratinocyte Model., PMID:26139628
Generation of specific monoclonal antibodies against the extracellular loops of human claudin-3 by immunizing mice with target-expressing cells., PMID:25744656
Ductal adenocarcinoma of the pancreas usually retained SMAD4 and p53 protein status as well as expression of epithelial-to-mesenchymal transition markers and cell cycle regulators at the stage of liver metastasis., PMID:25119169
Development of an anti-claudin-3 and -4 bispecific monoclonal antibody for cancer diagnosis and therapy., PMID:25118216
Enteroendocrine cells are specifically marked by cell surface expression of claudin-4 in mouse small intestine., PMID:24603700
Expression patterns of tight junction components induced by CD24 in an oral epithelial cell-culture model correlated to affected periodontal tissues., PMID:23713517
Immunotoxin-mediated targeting of claudin-4 inhibits the proliferation of cancer cells., PMID:23563899
Tight junction proteins claudin-3 and claudin-4 control tumor growth and metastases., PMID:23097631
Claudin expression in breast cancer: high or low, what to expect?, PMID:22936447
Targeting claudin-4 in human pancreatic cancer., PMID:22800288
Elucidating the signaling mechanism of an epithelial tight-junction opening induced by chitosan., PMID:22681978
M cell targeting by a Claudin 4 targeting peptide can enhance mucosal IgA responses., PMID:22413871
Ligation of CD24 expressed by oral epithelial cells induces kinase dependent decrease in paracellular permeability mediated by tight junction proteins., PMID:21806966
Anti-claudin-4-conjugated highly luminescent nanoparticles as biological labels for pancreatic cancer sensing., PMID:21717374
Laboratory methods in the study of endometrial Claudin-4., PMID:21717364
Claudin-4: a potential therapeutic target in chemotherapy-resistant ovarian cancer., PMID:21508375
Usefulness of Claudin 4 in the cytological diagnosis of serosal effusions., PMID:21488172
Transforming growth factor-β, a whey protein component, strengthens the intestinal barrier by upregulating claudin-4 in HT-29/B6 cells., PMID:21430244
[Target-specific cytotoxic activity of recombinant fusion toxin C-CPE-ETA' against CLDN-3,4-overexpressing ovarian cancer cells]., PMID:21223796
C terminus of Clostridium perfringens enterotoxin downregulates CLDN4 and sensitizes ovarian cancer cells to Taxol and Carboplatin., PMID:21123456
Characterization and evaluation of the antitumour activity of a dual-targeting monoclonal antibody against claudin-3 and claudin-4., PMID:21115905
The safety of a mucosal vaccine using the C-terminal fragment of Clostridium perfringens enterotoxin., PMID:21105580
Twist is inversely associated with claudins in germ cell tumors of the testis., PMID:20718715
Disruption of tight junction structure in salivary glands from Sjögren's syndrome patients is linked to proinflammatory cytokine exposure., PMID:20131287
Molecular characterization of cultured adult human liver progenitor cells., PMID:19874131
For research use only. Not for human or drug use.
