InVivoMAb Anti-Human PDGFC (Iv0073)

Catalog No.

VHJ65701

Species reactivity

Human

Host species

Human

Isotype

IgG1, kappa

Clonality

Monoclonal

Target

Spinal cord-derived growth factor, PDGFC receptor-binding form, SCDGF, PDGFC latent form, Fallotein, PDGF-C, VEGF-E, Platelet-derived growth factor C, PDGFC

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q9NRA1

Applications

ELISA, Neutralization

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

Iv0073

An atlas of early human mandibular endochondral and osteogenic paracrine signaling regions of Meckel's cartilage., PMID:40096606

Targeting PDGF-CC as a promising therapeutic strategy to inhibit cholangiocarcinoma progression., PMID:39543636

Platelet-Derived Growth Factor C Facilitates Malignant Behavior of Pancreatic Ductal Adenocarcinoma by Regulating SREBP1 Mediated Lipid Metabolism., PMID:39225567

Effects of salvianolic acid A and salvianolic acid B in renal interstitial fibrosis via PDGF-C/PDGFR-α signaling pathway., PMID:36057144

RNA N6-methyladenosine demethylase FTO promotes pancreatic cancer progression by inducing the autocrine activity of PDGFC in an m6A-YTHDF2-dependent manner., PMID:35422475

Roquin2 suppresses breast cancer progression by inhibiting tumor angiogenesis via selectively destabilizing proangiogenic factors mRNA., PMID:34345214

Platelet-Derived Growth Factor Receptor-α Subunit Targeting Suppresses Metastasis in Advanced Thyroid Cancer In Vitro and In Vivo., PMID:34031270

Cancer-associated fibroblast secretion of PDGFC promotes gastrointestinal stromal tumor growth and metastasis., PMID:33603171

Exogenous IL-4 shuts off pro-inflammation in neutrophils while stimulating anti-inflammation in macrophages to induce neutrophil phagocytosis following myocardial infarction., PMID:32574573

Mapping human serum-induced gene networks as a basis for the creation of biomimetic periosteum for bone repair., PMID:32522398

Hepatocyte Stress Increases Expression of Yes-Associated Protein and Transcriptional Coactivator With PDZ-Binding Motif in Hepatocytes to Promote Parenchymal Inflammation and Fibrosis., PMID:31505040

Intersubject and Intrasubject Variability of Potential Plasma and Urine Metabolite and Protein Biomarkers in Healthy Human Volunteers., PMID:31400148

Chemotherapeutic and antiangiogenic drugs beyond tumor progression in colon cancer: Evaluation of the effects of switched schedules and related pharmacodynamics., PMID:30953637

Stevioside inhibits experimental fibrosis by down-regulating profibrotic Smad pathways and blocking hepatic stellate cell activation., PMID:30561898

Development of monoclonal anti-PDGF-CC antibodies as tools for investigating human tissue expression and for blocking PDGF-CC induced PDGFRα signalling in vivo., PMID:30052660

PDGF-CC underlies resistance to VEGF-A inhibition and combinatorial targeting of both suppresses pathological angiogenesis more efficiently., PMID:27788490

MiR-29a Assists in Preventing the Activation of Human Stellate Cells and Promotes Recovery From Liver Fibrosis in Mice., PMID:27480597

Sulfatase 2 promotes breast cancer progression through regulating some tumor-related factors., PMID:26708018

tPA Deficiency in Mice Leads to Rearrangement in the Cerebrovascular Tree and Cerebroventricular Malformations., PMID:26648843

Role of platelet-derived growth factor-CC in capillary rarefaction in renal fibrosis., PMID:26216283

Naturally occurring PDGF receptor inhibitors with potential anti-atherosclerotic properties., PMID:25737405

Vasoprotective effect of PDGF-CC mediated by HMOX1 rescues retinal degeneration., PMID:25267616

Tissue-type plasminogen activator is not necessary for platelet-derived growth factor-c activation., PMID:24269585

Platelet-derived growth factor C and calpain-3 are modulators of human melanoma cell invasiveness., PMID:24126726

Analysis of mice lacking the heparin-binding splice isoform of platelet-derived growth factor A., PMID:23938297

Paracrine activation of hepatic stellate cells in platelet-derived growth factor C transgenic mice: evidence for stromal induction of hepatocellular carcinoma., PMID:23929039

Platelet-derived growth factor C promotes revascularization in ischemic limbs of diabetic mice., PMID:23856609

Peretinoin, an acyclic retinoid, improves the hepatic gene signature of chronic hepatitis C following curative therapy of hepatocellular carcinoma., PMID:23587162

Paracrine signalling in colorectal liver metastases involving tumor cell-derived PDGF-C and hepatic stellate cell-derived PAK-2., PMID:22362252

Platelet-derived growth factor C deficiency in C57BL/6 mice leads to abnormal cerebral vascularization, loss of neuroependymal integrity, and ventricular abnormalities., PMID:22230248

HIF-1α effects on angiogenic potential in human small cell lung carcinoma., PMID:21843314

Canonical hedgehog signaling augments tumor angiogenesis by induction of VEGF-A in stromal perivascular cells., PMID:21597001

PDGF-CC blockade inhibits pathological angiogenesis by acting on multiple cellular and molecular targets., PMID:20566880

Survival effect of PDGF-CC rescues neurons from apoptosis in both brain and retina by regulating GSK3beta phosphorylation., PMID:20231377

Cancer associated fibroblasts promote tumor growth and metastasis by modulating the tumor immune microenvironment in a 4T1 murine breast cancer model., PMID:19956757

Platelet-derived growth factor C is upregulated in human uterine fibroids and regulates uterine smooth muscle cell growth., PMID:19553600

Paracrine signaling by platelet-derived growth factor-CC promotes tumor growth by recruitment of cancer-associated fibroblasts., PMID:19118022

PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment., PMID:19111878

PDGF signalling controls the migration of mesoderm cells during chick gastrulation by regulating N-cadherin expression., PMID:18832396

Platelet-derived growth factor isoform expression in carbon tetrachloride-induced chronic liver injury., PMID:18663351

PDGF-C is a proinflammatory cytokine that mediates renal interstitial fibrosis., PMID:18184860

Plasmin is the major protease responsible for processing PDGF-C in the vitreous of patients with proliferative vitreoretinopathy., PMID:18172073

PDGF-C and -D induced proliferation/migration of human RPE is abolished by inflammatory cytokines., PMID:18055825

Targeting stromal cells for the treatment of platelet-derived growth factor C-induced hepatocellular carcinogenesis., PMID:17999742

Opposing actions of Stat1 and Stat6 on IL-13-induced up-regulation of early growth response-1 and platelet-derived growth factor ligands in pulmonary fibroblasts., PMID:16951379

Over-expression of PDGF-C using a lung specific promoter results in abnormal lung development., PMID:16830225

Tumor-driven paracrine platelet-derived growth factor receptor alpha signaling is a key determinant of stromal cell recruitment in a model of human lung carcinoma., PMID:16675559

Platelet-derived growth factor D induces cardiac fibrosis and proliferation of vascular smooth muscle cells in heart-specific transgenic mice., PMID:16224065

Microvascular rarefaction and decreased angiogenesis in rats with fetal programming of hypertension associated with exposure to a low-protein diet in utero., PMID:16037123

Platelet-derived growth factor D, tissue-specific expression in the eye, and a key role in control of lens epithelial cell proliferation., PMID:15611105

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