Catalog No.
YVV20601
Expression system
E. coli
Species
Human enterovirus 71 (EV71) (EV-71)
Protein length
Gly1549-Phe2193
Predicted molecular weight
73.84 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
A0A894JU04
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Genome polyprotein, Protease 3C, P3C, RNA-directed RNA polymerase, RdRp
Research progress on critical viral protease inhibitors for coronaviruses and enteroviruses., PMID:40074013
Production of a genetically encoded biosensor for evaluating enterovirus 71 3C protease inhibitors., PMID:40018827
Antiviral effects and mechanisms against EV71 of the novel 2-benzoxyl-phenylpyridine derivatives., PMID:37044201
Activation of Host Cellular Signaling and Mechanism of Enterovirus 71 Viral Proteins Associated with Hand, Foot and Mouth Disease., PMID:36298746
TRAF3IP3 Is Cleaved by EV71 3C Protease and Exhibits Antiviral Activity., PMID:35814660
Acrylamide fragment inhibitors that induce unprecedented conformational distortions in enterovirus 71 3C and SARS-CoV-2 main protease., PMID:35702321
EV71 3C protease cleaves host anti-viral factor OAS3 and enhances virus replication., PMID:35504537
Gasdermin E is required for induction of pyroptosis and severe disease during enterovirus 71 infection., PMID:35339492
Enterovirus 71 3C proteolytically processes the histone H3 N-terminal tail during infection., PMID:35256288
3C protease of enterovirus 71 cleaves promyelocytic leukemia protein and impairs PML-NBs production., PMID:34930370
4-Iminooxazolidin-2-One as a Bioisostere of Cyanohydrin Suppresses EV71 Proliferation by Targeting 3Cpro., PMID:34787443
Antiviral Activity of Chrysin against Influenza Virus Replication via Inhibition of Autophagy., PMID:34372556
Ectopic Expression of TRIM25 Restores RIG-I Expression and IFN Production Reduced by Multiple Enteroviruses 3Cpro., PMID:34170466
Reversible covalent inhibitors suppress enterovirus 71 infection by targeting the 3C protease., PMID:34082057
Design, Synthesis, and Biological Evaluation of Peptidomimetic Aldehydes as Broad-Spectrum Inhibitors against Enterovirus and SARS-CoV-2., PMID:33872498
The Function and Mechanism of Enterovirus 71 (EV71) 3C Protease., PMID:32556480
Design, synthesis, and evaluation of a novel macrocyclic anti-EV71 agent., PMID:32503695
Virucidal activity and the antiviral mechanism of acidic polysaccharides against Enterovirus 71 infection in vitro., PMID:31785100
Activity-Based Protein Profiling Identifies ATG4B as a Key Host Factor for Enterovirus 71 Proliferation., PMID:31554687
EV71 3C protease induces apoptosis by cleavage of hnRNP A1 to promote apaf-1 translation., PMID:31498791
Determination of the cleavage site of enterovirus 71 VP0 and the effect of this cleavage on viral infectivity and assembly., PMID:31195113
Characteristics of enterovirus 71-induced cell death and genome scanning to identify viral genes involved in virus-induced cell apoptosis., PMID:30910697
Transcriptomic analysis of cells in response to EV71 infection and 2Apro as a trigger for apoptosis via TXNIP gene., PMID:30499052
An update on enterovirus 71 infection and interferon type I response., PMID:30378208
4-Iminooxazolidin-2-one as a Bioisostere of the Cyanohydrin Moiety: Inhibitors of Enterovirus 71 3C Protease., PMID:30365311
Coxsackievirus A6 Induces Cell Cycle Arrest in G0/G1 Phase for Viral Production., PMID:30159255
Inhibition of enterovirus 71 replication and viral 3C protease by quercetin., PMID:30064445
Enterovirus 71 inhibits cytoplasmic stress granule formation during the late stage of infection., PMID:30006004
Promyelocytic Leukemia Restricts Enterovirus 71 Replication by Inhibiting Autophagy., PMID:29922292
Picornavirus 2A protease regulates stress granule formation to facilitate viral translation., PMID:29415027
Development of a luciferase-based biosensor to assess enterovirus 71 3C protease activity in living cells., PMID:28871120
Association of EV71 3C polymorphisms with clinical severity., PMID:28711442
Enterovirus 71 Inhibits Pyroptosis through Cleavage of Gasdermin D., PMID:28679757
Structure of the Enterovirus 71 3C Protease in Complex with NK-1.8k and Indications for the Development of Antienterovirus Protease Inhibitor., PMID:28461310
Enterovirus 71 suppresses interferon responses by blocking Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling through inducing karyopherin-α1 degradation., PMID:28455446
A Novel Enterovirus 71 (EV71) Virulence Determinant: The 69th Residue of 3C Protease Modulates Pathogenicity., PMID:28217559
Enterovirus 71 3C Promotes Apoptosis through Cleavage of PinX1, a Telomere Binding Protein., PMID:27847364
Identification and biochemical characterization of DC07090 as a novel potent small molecule inhibitor against human enterovirus 71 3C protease by structure-based virtual screening., PMID:27776325
Antiviral activities of peptide-based covalent inhibitors of the Enterovirus 71 3C protease., PMID:27645381
Optimize the interactions at S4 with efficient inhibitors targeting 3C proteinase from enterovirus 71., PMID:27185390
Fragment-wise design of inhibitors to 3C proteinase from enterovirus 71., PMID:26987809
Synthesis and structure-activity relationship of α-keto amides as enterovirus 71 3C protease inhibitors., PMID:26916437
Luteoloside Acts as 3C Protease Inhibitor of Enterovirus 71 In Vitro., PMID:26870944
Cyanohydrin as an Anchoring Group for Potent and Selective Inhibitors of Enterovirus 71 3C Protease., PMID:26571192
Reciprocal Regulation between Enterovirus 71 and the NLRP3 Inflammasome., PMID:26119741
Expression of enterovirus 71 virus-like particles in transgenic enoki (Flammulina velutipes)., PMID:25957149
Recombinant adeno-vaccine expressing enterovirus 71-like particles against hand, foot, and mouth disease., PMID:25855976
Peptidomimetic ethyl propenoate covalent inhibitors of the enterovirus 71 3C protease: a P2-P4 study., PMID:25792507
Peptidyl aldehyde NK-1.8k suppresses enterovirus 71 and enterovirus 68 infection by targeting protease 3C., PMID:25691647
Biochemical characterization of recombinant Enterovirus 71 3C protease with fluorogenic model peptide substrates and development of a biochemical assay., PMID:25421478
For research use only. Not for human or drug use.
