Catalog No.
DHB95501
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Humanized
Isotype
IgG1-kappa
Clonality
Monoclonal
Target
IL1F1, Interleukin-1 alpha, IL1A, Hematopoietin-1, IL-1 alpha
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P01583
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
MABp1, Xilonix-, CAS: 1401965-15-8
Clone ID
Bermekimab
A Phase II Open-Label Study of Bermekimab in Patients with Hidradenitis Suppurativa Shows Resolution of Inflammatory Lesions and Pain, PMID: 32004568
A randomized phase II study of Xilonix, a targeted therapy against interleukin 1α, for the prevention of superficial femoral artery restenosis after percutaneous revascularization, PMID: 26433546
Efficacy of non-surgical monotherapies for hidradenitis suppurativa: a systematic review and network meta-analyses of randomized trials, PMID: 33961535
Interleukin 1α: a comprehensive review on the role of IL-1α in the pathogenesis and treatment of autoimmune and inflammatory diseases, PMID: 33482337
Interleukin-1 receptor antagonist levels predict favorable outcome after bermekimab, a first-in-class true human interleukin-1α antibody, in a phase III randomized study of advanced colorectal cancer, PMID: 30723583
Pharmacological development in hidradenitis suppurativa, PMID: 31075754
Systematic review of immunomodulatory therapies for hidradenitis suppurativa, PMID: 31190730
Target molecules for future hidradenitis suppurativa treatment, PMID: 34085329
Targeting IL-1α in cancer cachexia: a narrative review, PMID: 30300155
Xilonix, a novel true human antibody targeting the inflammatory cytokine interleukin-1 alpha, in non-small cell lung cancer, PMID: 25822109
For research use only. Not for human or drug use.
